Notice of Funding Opportunity PS-23-006: Identifying and Addressing Historical and Structural Drivers of Medical Mistrust among Hispanic/Latino Gay, Bisexual and Other Men Who Have Sex with Men (HLMSM) for HIV Prevention

This website is designed to:

  • Support the application process for health departments applying for Notice of Funding Opportunity (NOFO) PS-23-006, and
  • Provide a forum for the dissemination of important information to potential applicants.

Executive Summary

The root causes for medical mistrust (MM) in Hispanic/Latino (H/L) populations in the United States are understudied. MM is a social determinant of health associated with HIV disparities within H/L gay, bisexual and other men who have sex with men (HLMSM) (e.g., low PrEP willingness and adherence) that prevents and delays access and engagement in HIV prevention and care services (such as PrEP, ART). The little research on MM among HLMSM has neither utilized a heterogeneous H/L population with different ethnic groups (e.g., Cuban, Mexican, Puerto Rican), nor addressed the historical roots and relevance of MM to healthcare access. This 5-year NOFO targets EHE initiative jurisdictions with large H/L populations (30% or more based on 2020 US Census data) and will support research that captures variations in medical mistrust drivers among different H/L subgroups (e.g., Central Americans, Mexicans, Puerto Ricans, US-born, non-US-born, 1st generation, 2nd generation). Grounded in community-based participatory research (CBPR) principles, the objectives of this 2-phase NOFO are to: 1) identify MM drivers in HLMSM and existing interventions that build trust in health services via formative research (Phase 1); and (2) evaluate implementation of targeted multilevel interventions that build trust in health services (Phase 2).


Evidence generated in this project will bridge the gap in knowledge on causes of medical mistrust among HLMSM for status neutral HIV prevention and care services and will help address a driver of HIV disparities in support of the goals of EHE, the National HIV Strategic Plan, and other federal prevention planning efforts.

Application is due on 02/23/2023 and can be downloaded from or
Please direct questions to
Jocelyn Patterson Mosley, MPH, MA, Scientific/Research Contact, 404-639-6437.