Notice of Funding Opportunity PS-23-004: Long-Acting Injectables for the Treatment of HIV in Non-Clinic Community-Based Settings

This website is designed to:

• Support the application process for health departments applying for Notice of Funding Opportunity (NOFO) PS-23-004, and
• Provide a forum for the dissemination of important information to potential applicants.

This Notice of Funding Opportunity announcement is available at www.grants.gov. The view the entire announcement go to www.grants.gov and click on the “Search Grants” tab. Then enter  “RFA-PS-23-004” into the “Basic Search Criteria-Opportunity Announcement. To learn more about the CDC application process, visit grants.gov How to Apply for Grants webpage.

Executive Summary

Long-acting injectable (LAI) antiretroviral therapy (ART) offers many potential advantages over daily oral treatment such as improved convenience, adherence, and treatment satisfaction. Barriers and challenges exist with implementation of LAI-ART into current healthcare practice, both in logistics and in equity. Some of these barriers may be overcome by using non-clinic sites, such as community pharmacies, to administer LAI-ART. This Notice of Funding Opportunity (NOFO) will support research on LAI-ART by implementing LAI-ART administration in non-clinic settings. A multi-site effectiveness-implementation research study, designed to compare receiving LAI-ART in non-clinic community settings with the oral standard-of-care HIV clinical treatment, should offer a unique source of information for improving acceptability, availability, and uptake of LAI-ART. Implementation outcomes of interest include acceptability, perceived barriers and facilitators, feasibility, and sustainability. Health outcomes of interest include missed visits, on-time receipt of injections, and the HIV care continuum, including retention in care and viral load suppression. Applied qualitative and quantitative research resulting from this funding is expected to strengthen adherence to ART and is aligned with the National HIV/AIDS Strategy (NHAS) and the Ending the HIV Epidemic in the U.S. (EHE) initiative “Treat” Pillar.

Purpose

The purpose of this NOFO is to support research on long-acting injectable (LAI) antiretroviral therapy (ART) by implementing LAI-ART administration in non-clinic settings. Utilizing an innovative strategy of LAI-ART administration in non-clinic-based settings to decentralize the delivery of LAI-ART for HIV treatment will expand treatment opportunities. Recipients of this NOFO will conduct qualitative and quantitative research resulting in data describing real-world LAI-ART use in an era of multiple HIV treatment modalities.

Application is due on 02/27/2023. Please direct questions to Jocelyn Patterson Mosley, MPH, MA, Scientific/Research Contact JPatterson@cdc.gov, 404-639-6437.