Notice of Funding Opportunity PS22-2211: Enhanced Surveillance of Persons with Early and Late HIV Diagnosis

This website is designed to:

  • Support the application process for health departments applying for Notice of Funding Opportunity (NOFO) PS22-2211, and
  • Provide a forum for the dissemination of important information to potential applicants.

Access the Notice of Funding Opportunity

Executive Summary

Despite the powerful prevention tools and varied modalities now available to diagnose, treat, and prevent HIV, new HIV infections continue to occur in the United States. Each new HIV infection is considered a failure of HIV prevention. A substantial proportion of new HIV diagnoses in the United States are classified as early (stage 0) or late (stage 3) diagnoses. Early and late diagnoses present opportunities to examine failures of HIV prevention and testing services to reach those who need them most. Enhanced surveillance of people with early and late diagnoses is needed to identify actionable missed opportunities for early diagnosis and prevention. This Notice of Funding Opportunity will support enhanced surveillance among persons with early or late HIV diagnoses to inform understanding of individual- and systems-level barriers that prevent people from fully realizing the benefits of current prevention and testing interventions. Strategies and activities include identifying, contacting, and recruiting people who received an early or late HIV diagnosis in the past year to participate in behavioral interviews to be conducted by a CDC contractor. Recipients will also engage local community partners to ensure appropriateness of recruitment approaches and disseminate findings to the community. These strategies and activities will contribute to efforts to improve uptake of HIV prevention and testing services and ultimately reduce new HIV infections in the United States.


This NOFO will support identification and recruitment of adults with recent HIV diagnoses at stage 0 and stage 3 to improve understanding of barriers and gaps associated with new infection and late diagnosis in the era of multiple testing modalities and prevention options such as PrEP. These enhanced surveillance activities will identify actionable missed opportunities for early diagnosis and prevention, thus informing allocation of resources, development and prioritization of interventions, and evidence-based local and national decisions to improve HIV testing and address prevention gaps.