Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 1314–62–1
NIOSH REL: 0.05 mg V/m3 15-minute CEILING
Current OSHA PEL: 0.5 mg V2O5/m3 (respirable dust) CEILING
1989 OSHA PEL: 0.05 mg V2O5/m3 (respirable dust) TWA
1993-1994 ACGIH TLV: 0.05 mg V2O5/m3 (respirable dust) TWA
Description of substance: Yellow-orange powder or dark-gray, odorless flakes dispersed in air.
LEL: . . Noncombustible Solid
Original (SCP) IDLH: 70 mg/m3 (as V2O5)
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH  that vanadium pentoxide dust at 70 mg/m3 is fatal to animals within a few hours [Hudson 1964]. AIHA  reported that rabbits succumb from edema of the lungs at 200 mg/m3 after one 7-hour exposure [Sjoberg 1950].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
|Species||Reference||LC50||LCLo||Time||Adjusted 0.5-hrLC (CF)||Derived value|
|Cat||Faulkner 1964||—–||500 mg/m3||23 min||256 mg V/m3 (0.915)||26 mg V/m3|
|Rat||Izrael’son 1963||—–||70 mg/m3||2 hr||63 mg V/m3 (1.6)||6.3 mg V/m3|
Lethal dose data:
|Species||Reference||Route||LD50(mg/kg)||LDLo(mg/kg)||Adjusted LD||Derived value|
|Rat||Arch Toxikol 1956||oral||10||—–||39 mg V/m3||3.9 mg V/m3|
|Mouse||Izmerov et al. 1982||oral||23||—–||90 mg V/m3||9.0 mg V/m3|
Human data: Respiratory irritation following exposures to V2O5 ranging from 1 to 48 mg V/m3 has been described in workers [Sjoberg 1955]. Vanadium intoxication (i.e., rhinorrhea, sneezing, lacrimation, and sore throat) has been reported in workers exposed to concentrations of V2O5 during the workshift ranging from 10 to 33 mg/m3 [Williams 1952]. Concentrations of V2O5 exceeding 56 mg V/m3 have resulted in local respiratory effects [Vintinner et al. 1955]. Other workers exposed intermittently to 56 mg V/m3 showed no evidence of intoxication [McTurk et al. 1956].
|Revised IDLH: 35 mg V/m3Basis for revised IDLH: Based on acute inhalation toxicity data in workers [McTurk et al. 1956; Sjoberg 1955; Vintinner et al. 1955; Williams 1952], the revised IDLH for vanadium dust is 35 mg V/m3.|
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2. AIHA . Vanadium pentoxide. In: Hygienic guide series. Am Ind Hyg Assoc Q 18:172-173.
3. Arch Toxikol ; 16:182-189 (in German).
4. Faulkner TG . Vanadium toxicology and biological significance. New York, NY: Elsevier Science Publishing Co., p. 72.
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6. Izmerov NF, Sanotsky IV, Sidorov KK . Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 119.
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11. Vintinner FJ, Vallenas R, Carlin CE, Weiss R, Macher C, Ochoa R . Study of the health of workers employed in mining and processing of vanadium ore. AMA Arch Ind Health 12:635-642.
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