2-Nitropropane

May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)

CAS number: 79–46–9

NIOSH REL: None established; NIOSH considers 2-nitropropane to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].

Current OSHA PEL: 25 ppm (90 mg/m3) TWA

1989 OSHA PEL: 10 ppm (35 mg/m3) TWA

1993-1994 ACGIH TLV: 10 ppm (36 mg/m3) TWA, A2

Description of substance: Colorless liquid with a pleasant, fruity odor.

LEL: . . 2.6% (10% LEL, 2,600 ppm)

Original (SCP) IDLH: 2,300 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Patty [1963] that the lowest lethal concentration for the cat for a 1-hour exposure was found to be 2,353 ppm; the response of different species to 2-nitropropane varies considerably, but the cat was the most sensitive species in this investigation [Treon and Dutra 1952].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

Species Reference LC50 (ppm) LCLo (ppm) Time Adjusted 0.5-hr LC (CF) Derived value
MouseRat

Cat

Rabbit

G. pig

Cat

Izmerov et al. 1982Lewis et al. 1979

Treon & Dutra 1952

Treon & Dutra 1952

Treon & Dutra 1952

Treon & Dutra 1952

2,703400

—–

—–

—–

—–

———-

714

2,381

4,622

2,353

2 hr6 hr

5 hr

5 hr

5 hr

1 hr

4,324 ppm (1.6)920 ppm (2.3)

1,535 ppm (2.15)

5,119 ppm (2.15)

9,937 ppm (2.15)

2,941 ppm (1.25)

432 ppm92 ppm

154 ppm

512 ppm

994 ppm

294 ppm

Human data: Nausea, vomiting, diarrhea, anorexia, and severe headache have been reported in workers exposed to daily concentrations of 20 to 45 ppm [Skinner 1947].

REFERENCES:

1. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 94.

2. Lewis TR, Ulrich CE, Busey WM [1979]. Subchronic inhalation toxicity of nitromethane and 2-nitropropane in rats. J Environ Pathol Toxicol 2(5):233-249.

3. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., pp. 2077-2078.

4. Skinner JB [1947]. The toxicity of 2-nitropropane. Ind Med 16(9):441-443.

5. Treon JF, Dutra FR [1952]. Physiological response of experimental animals to the vapor of 2-nitropropane. AMA Arch Ind Hyg Occup Med 5:52-61.

Page last reviewed: December 4, 2014