Tetramethyl lead (as Pb)
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 75–74–1
NIOSH REL: 0.075 mg/m3 TWA [skin]
Current OSHA PEL: 0.075 mg/m3 TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 0.15 mg/m3 TWA [skin]
Description of substance: Colorless liquid (unless dyed red, orange, or blue) with a fruity odor.
LEL: . . Unknown
Original (SCP) IDLH: 40 mg Pb/m3
Basis for original (SCP) IDLH: The chosen IDLH is based on an analogy with tetraethyl lead which has an IDLH of 40 mg Pb/m3.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
|Species||Reference||LC50||LCLo||Time||Adjusted 0.5-hrLC (CF)||Derived value|
|Mouse||Castellino et al.1963||40,800 mg/m3||—–||30 min||31,626 mg Pb/m3 (1.0)||3,163 mg Pb/m3|
|Rat||Cremer &Calloway 1961||8,870 mg/m3||—–||30 min||6,876 mg Pb/m3 (1.0)||688 mg Pb/m3|
|Mouse||Marhold 1986||—–||8,500 mg/m3||30 min||6,589 mg Pb/m3 (1.0)||659 mg Pb/m3|
Lethal dose data:
|Species||Reference||Route||LD50(mg/kg)||LDLo(mg/kg)||Adjusted LD||Derived value|
|Akatsuka 1973Gekkan Yakuji 1980
Magistretti et al. 1963
|130 mg Pb/m3591 mg Pb/m3
570 mg Pb/m3
|13 mg Pb/m359 mg Pb/m3
57 mg Pb/m3
Other animal data: It has been reported that signs of acute tetramethyl lead intoxication in rats were similar to that seen after acute poisoning with tetraethyl lead [ACGIH 1991].
Human data: None relevant for use in determining the revised IDLH.
|Revised IDLH: 40 mg Pb/m3 [Unchanged]Basis for revised IDLH: Based on acute inhalation toxicity data in animals [Castellino et al. 1963; Cremer and Calloway 1961; Marhold 1986], a value of 150 mg Pb/m3 (i.e., 2,000 times the NIOSH REL) would have been appropriate for tetramethyl lead. However based on an analogy to tetraethyl lead which has a revised IDLH of 40 mg Pb/m3, the original IDLH for tetramethyl lead (40 mg Pb/m3) is not being revised at this time|
1. ACGIH . Tetramethyl lead. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1521-1523.
2. Akatsuka K . Tetraalkyl lead poisoning. Sangyo Igaku (Japanese Journal of Industrial Health) 15:3-66.
3. Castellino N, Rossi A, Mole R . Miscellanea: toxicity of tetramethyl lead solutions to mice and rabbits. Brit J Ind Med 20:63-65.
4. Cremer JE, Calloway S . Further studies on the toxicity of some tetra and trialkyl lead compounds. Brit J Ind Med 18:277-282.
5. Gekkan Yakuji (Pharmaceuticals Monthly) ; 22(3):455-459 (in Japanese).
6. Magistretti M, Zurlo N, Scollo F, Pacillo D . Tossicita comparata del piombo tetra-etile e del piombo tetra-metile. Med Lav 54:486-495 (in Italian).
7. Marhold J . Prehled Prumyslove Toxikologie, Organicke Latky. Prague, Czechoslovakia: Avicenum, p. 1258 (in Czechoslovakian).
- Page last reviewed: December 4, 2014
- Page last updated: December 4, 2014
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