n-Butyl alcohol

May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)

CAS number: 71–36–3

NIOSH REL: 50 ppm (150 mg/m3) CEILING [skin]

Current OSHA PEL: 100 ppm (300 mg/m3) TWA

1989 OSHA PEL: 50 ppm (150 mg/m3) CEILING [skin]

1993-1994 ACGIH TLV: 50 ppm (152 mg/m3) CEILING [skin]

Description of Substance: Colorless liquid with a strong, characteristic, mildly alcoholic odor.

LEL: . . 1.4% (10% LEL, 1,400 ppm)

Original (SCP) IDLH: 8,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is conservative, but the only data available on which to base the IDLH is the statement by Patty [1963] that Smyth [1956] found rats survived when exposed for 4 hours to 8,000 ppm. The IDLH for isobutyl alcohol is also 8,000 ppm.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species Reference LC5o(ppm) LCLo(ppm) Time Adjusted 0.5-hrLC (CF) DerivedValue
MammalRat Esin and Vigdergauz 1986NPIRI 1974 9,2218,000 ———- ?4 hr ?16,000 ppm (2.0) ?1,600 ppm

 

Lethal dose data:

Species Reference Route LD50(mg/kg) LDLo(mg/kg) Adjusted LD Derived value
RabbitRat

Dog

Munch 1972Purchase 1969

Wurtz 1975

oraloral

oral

———-

—–

3,484790

1,700

7,918 ppm1,795 ppm

4,000 ppm

792 ppm180 ppm

400 ppm

Other animal data: RD50 (mouse), 4,784 ppm [Alarie 1981].

Human data: It has been reported that corneal irritation was occasionally observed in workers exposed to 200 ppm [Sterner et al. 1949].

 

REFERENCES:

1. Alarie Y [1981]. Dose-response analysis in animal studies: prediction of human responses. Environ Health Perspect 42:9-13.

2. Esin MS, Vigdergauz MS [1986]. Correlation between toxicity indexes and chromatographic characteristics of chemical substances. Gig Sanit 51(5):61-62 (in Russian).

3. Munch JC [1972]. Aliphatic alcohols and alkyl esters: narcotic and lethal potencies to tadpoles and to rabbits. Ind Med Surg 41:31-33.

4. NPIRI [1974]. Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Vol. 1. Organic solvents. Bethlehem, PA: National Printing Ink Research Institute, p. 10.

5. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1443.

6. Purchase IFH [1969]. Studies in kaffircorn malting and brewing. XXII. The acute toxicity of some fusel oils found in Bantu beer. S Afr Med J 43:795-798.

7. Smyth HF Jr [1956]. Improved communication: hygienic standards for daily inhalation. Am Ind Hyg Assoc Q 17(2):129-185.

8. Sterner JH, Crouch HC, Brockmyre HF, Cusack M [1949]. A ten-year study of butyl alcohol exposure. Am Ind Hyg Assoc Q 10:53-59.

9. Wurtz M [1975]. Sur les proprietes toxiques des alcools par fermentation. Comp Rend Hebdom 81:192-194 (in French).

Page last reviewed: December 4, 2014