sec-Amyl acetate
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 626-38-0
NIOSH REL: 125 ppm (650 mg/m3) TWA
Current OSHA PEL: 125 ppm (650 mg/m3) TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 125 ppm (665 mg/m3) TWA
Description of substance: Colorless liquid with a mild odor.
LEL: 1% (10% LEL, 1,000 ppm)
Original (SCP) IDLH: 9,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that 9,200 ppm was lethal to guinea pigs in 7 hours [Patty et al. 1936]. This is the only data on acute inhalation toxicity available on which to base the IDLH.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Adjusted | ||||||
|---|---|---|---|---|---|---|
| LC50 | LCLo | 0.5-hr | Derived | |||
| Species | Reference | (ppm) | (ppm) | Time | LC (CF) | Value |
| G. pig | Patty et al. 1936 | ----- | 9,200 | 7 hr | 22,080 ppm (2.4) | 2,208 ppm |
| G. pig | von Oettingen 1960 | ----- | 10,000 | 5 hr | 21,500 ppm (2.15) | 2,150 ppm |
Human data: It has been stated that exposure to 1,000 ppm for an hour may be expected to produce serious toxic effects [von Oettingen 1960].
Revised IDLH: 1,000 ppm Basis for revised IDLH: The revised IDLH for sec-amyl acetate is 1,000 ppm based on acute inhalation toxicity data in humans [von Oettingen 1960] and the similarity of the toxic effects of sec-amyl acetate to those of n-amyl acetate (which also has a revised IDLH of 1,000 ppm). |
References:
- ACGIH [1971]. sec-Amyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 13.
- Patty FA, Yant WP, Schrenk HH [1936]. Acute response of guinea pigs to vapors of some new commercial organic compounds. XI. Secondary amyl acetate. Public Health Rep 51(25):811-819.
- von Oettingen WF [1960]. The aliphatic acids and their esters: toxicity and potential dangers. AMA Arch Ind Health 21:40/28-77/65.