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May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)

CAS number: 600–25–9

NIOSH REL: 2 ppm (10 mg/m3) TWA

Current OSHA PEL: 20 ppm (100 mg/m3) TWA

1989 OSHA PEL: 2 ppm (10 mg/m3) TWA

1993-1994 ACGIH TLV: 2 ppm (10 mg/m3) TWA

Description of Substance: Colorless liquid with an unpleasant odor.

LEL: . . Unknown

Original (SCP) IDLH: 2,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement in Patty [1963] that 1 of 2 guinea pigs died following a 1-hour exposure to 2,178 ppm; no rabbits died from this exposure, and no rabbits or guinea pigs died from a 1-hour exposure to 1,069 ppm [Machle et al. 1945].

Short-term exposure guidelines: None developed


Lethal concentration data:

Species Reference LC50(ppm) LCLo(ppm) Time Adjusted 0.5-hrLC (CF) Derivedvalue
G. pigRabbit


G. pig


Machle et al. 1945Machle et al. 1945

Machle et al. 1945

Machle et al. 1945

Neklesova and Kudrina 1969


LC100: 2,574







1 hr6 hr

6 hr

2 hr

3 hr

2,723 ppm (1.25)895 ppm (2.3)

5,920 ppm (2.3)

5,603 ppm (1.6)

23,112 ppm (1.8)

272 ppm90 ppm

592 ppm

560 ppm

2,311 ppm


Lethal dose data:

Species Reference Route LD50(mg/kg) LDLo(mg/kg) Adjusted LD Derived value


Machle et al. 1945Marhold 1986

Neklesova and Kudrina 1969







68 ppm68 ppm

695 ppm

6.8 ppm6.8 ppm

70 ppm


Human data None relevant for use in determining the revised IDLH.

Revised IDLH: 100 ppmBasis for revised IDLH: The revised IDLH for 1-chloro-1-nitropropane is 100 ppm based on acute inhalation toxicity data in animals [Machle et al. 1945].



1. Machle W, Scott EW, Treon JF, Heyroth FF, Kitzmiller KV [1945]. The physiological response of animals to certain chlorinated mononitroparaffins. J Ind Hyg Toxicol 27(4):95-102.

2. Marhold J [1986]. Prehled Prumyslove Toxikologie, Organicke Latky. Prague, Czechoslovakia: Avicenum, p. 596 (in Czechoslovakian).

3. Neklesova ID, Kudrina MA [1969]. Comparative toxicological characteristics of certain chloronitroparaffins. Gig Sanit 34(10-12):429-432 (translated).

4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 2082.