Di-sec octyl phthalate
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 117–81–7
NIOSH REL: 5 mg/m3 TWA, 10 mg/m3 STEL; NIOSH considers di-sec octyl phthalate to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
Current OSHA PEL: 5 mg/m3 TWA
1989 OSHA PEL: 5 mg/m3 TWA, 10 mg/m3 STEL
1993-1994 ACGIH TLV: 5 mg/m3 TWA, 10 mg/m3 STEL
Description of Substance: Colorless, oily liquid with a slight odor.
LEL(@474 F): 0.3% (10% LEL(@474 F), 8,600 mg/m3)
Original (SCP) IDLH*: Unknown [*Note: “Effective” IDLH = 5,000 mg/m3 — see discussion below.]
Basis for original (SCP) IDLH: Patty  made the statement that inhalation of the vapor-mist mixture produced by bubbling air through a column of plasticizer maintained at 170 C could be tolerated for 2 hours without producing fatalities. In a 4-hour period, however, all rats had succumbed. On the basis of these experiments, the hazard to exposed workers should be very low under ordinary circumstances. Because di-sec octyl phthalate has such a low toxicity, respirators have been selected on the basis of the assigned protection factor afforded by each device up to 1,000 × the OSHA PEL of 5 mg/m3 (i.e., 5,000 mg/m3); only the “most protective” respirators are permitted for use in concentrations exceeding 5,000 mg/m3.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal dose data:
|Species||Reference||Route||LD50(mg/kg)||LDLo(mg/kg)||Adjusted LD||Derived value|
|Autian 1973Autian 1973
Shibko and Blumenthal 1973
Yagi et al. 1976
|238,000 mg/m3182,000 mg/m3
|23,800 mg/m318,200 mg/m3
Human data: None relevant for use in determining the revised IDLH.
|Revised IDLH: 5,000 mg/m3Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for di-sec octyl phthalate. Since the acute oral toxicity data in animals [Autian 1973; Shibko and Blumenthal 1973; Yagi et al. 1976] indicates that di-sec octyl phthalate has low acute toxicity, the revised IDLH for di-sec octyl phthalate is 5,000 mg/m3 based on being 1,000 times the OSHA PEL of 5 mg/m3 (1,000 is an assigned protection factor for respirators and was used during the Standards Completion Program for deciding when the “most protective” respirators should be used for di-sec octyl phthalate). [Note: NIOSH recommends as part of its carcinogen policy that the “most protective” respirators be worn for di-sec octyl phthalate at concentrations above 5 mg/m3.]|
1. Autian J . Toxicity and health threats of phthalate esters: review of the literature. Environ Health Perspect 4:3-26.
2. Patty FA, ed. . Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1909.
3. Shibko SI, Blumenthal H . Toxicology of phthalic acid esters used in food-packaging material. Environ Health Perspect 3:131-137.
4. Yagi Y, Tutikawa K, Shimoi N . Teratogenicity and mutagenicity of a phthalate ester. Int J Abnorm Develop 14(2):259 [Abstract].