Ethyl formate

May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)

CAS number: 109–94–4

NIOSH REL: 100 ppm (300 mg/m3) TWA

Current OSHA PEL: 100 ppm (300 mg/m3) TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 100 ppm (303 mg/m3) TWA

Description of Substance: Colorless liquid with a fruity odor.

LEL:. . 2.8% (10% LEL, 2,800 ppm)

Original (SCP) IDLH: 8,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statements by Smyth [1956] cited in Patty [1963] and by UCC [1968] that 5 of 6 rats died following a 4-hour exposure to 8,000 ppm and no rats died from a 4-hour exposure to 4,000 ppm.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species Reference LC50(ppm) LCLo(ppm) Time Adjusted 0.5-hrLC (CF) Derivedvalue
CatRat

Rat

Flury and Zernik 1931Smyth 1956

Smyth et al. 1954

—–LC83: 8,000

—–

10,000—–

8,000

1.5 hr4 hr

4 hr

14,500 ppm (1.45)16,000 ppm (2.0)

16,000 ppm (2.0)

1,450 ppm1,600 ppm

1,600 ppm

 

Lethal dose data:

Species Reference Route LD50(mg/kg) LDLo(mg/kg) Adjusted LD Derived value
RatG. pig

Rabbit

Jenner et al. 1964Jenner et al. 1964

Munch 1972

oraloral

oral

1,8501,110

2,075

———-

—–

4,205 ppm2,523 ppm

4,716 ppm

421 ppm252 ppm

472 ppm

 

Other animal data: It has been stated that rats have survived a 4-hour exposure to 4,000 ppm [UCC 1968].

Human data: It has been reported that 330 ppm produced slight eye irritation and rapidly increasing nasal irritation [Flury and Zernik 1931].

 

REFERENCES:

1. Flury F, Zernik F [1931]. Schädliche gase dämpfe, nebel, rauch- und staubarten. Berlin, Germany: Verlag von Julius Springer, p. 375 (in German).

2. Jenner PM, Hagan EC, Taylor JM, Cook EL, Fitzhugh OG [1964]. Food flavourings and compounds of related structure. I. Acute oral toxicity. Food Cosmet Toxicol 2:327-343.

3. Munch JC [1972]. Aliphatic alcohols and alkyl esters: narcotic and lethal potencies to tadpoles and to rabbits. Ind Med Surg 41:31-33.

4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1855.

5. Smyth HF Jr [1956]. Improved communication: hygienic standards for daily inhalation. Am Ind Hyg Assoc Q 17(2):129-185.

6. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med 10:61-68.

7. UCC [1968]. Toxicology studies: ethyl formate. New York, NY: Union Carbide Corporation.

Page last reviewed: December 4, 2014