Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 100–61–8
NIOSH REL: 0.5 ppm (2 mg/m3) TWA [skin]
Current OSHA PEL: 2 ppm (9 mg/m3) TWA [skin]
1989 OSHA PEL: 0.5 ppm (2 mg/m3) TWA [skin]
1993-1994 ACGIH TLV: 0.5 ppm (2.2 mg/m3) TWA [skin]
Description of substance: Yellow to light-brown liquid with a weak, ammonia-like odor.
LEL: . . . Unknown
Original (SCP) IDLH: 100 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on an analogy with aniline which has an IDLH of 100 ppm.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal dose data:
|Species||Reference||Route||LD50 (mg/kg)||LDLo (mg/kg)||Adjusted LD||Derived value|
|RabbitG. pig||Treon et al. 1949von Oettingen 1941||oraloral||———-||2801,200||439 ppm1,883 ppm||44 ppm188 ppm|
Other animal data: It has been reported that a dog survived 50 seven-hour exposures to 86 ppm [Treon et al. 1949].
Human data: None relevant for use in determining the revised IDLH.
|Revised IDLH: 100 ppm [Unchanged]Basis for revised IDLH: Based on animal subchronic inhalation toxicity data [Treon et al. 1949] and an analogy to aniline which has a revised IDLH of 100 ppm, the original IDLH for monomethyl aniline (100 ppm) is not being revised at this time.|
1. Treon JF, Deichmann WB, Sigmon HE, Wright H, Witherup SO, Heyroth FF, Kitzmiller KV, Keenan C . The toxic properties of xylidine and monomethylaniline. I. The comparative toxicity of xylidine and monomethylaniline when administered orally or intravenously to animals or applied on their skin. J Ind Hyg Toxicol 31:1-20.
2. von Oettingen WF . The aromatic amino and nitro compounds, their toxicity and potential dangers. Public Health Bulletin 271:16.