Phosphorus pentachloride

May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)

CAS number: 10026–13–8

NIOSH REL: 1 mg/m3 TWA

Current OSHA PEL: 1 mg/m3 TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 0.85 mg/m3 (0.1 ppm) TWA

Description of substance: White to pale-yellow, crystalline solid with a pungent, unpleasant odor.

LEL: . . Noncombustible Solid

Original (SCP) IDLH: 200 mg/m3

Basis for original (SCP) IDLH: The chosen IDLH is based on an analogy with phosphorus trichloride (PCl3) and statements by Henderson and Haggard [1943] that 2 to 4 ppm Pcl3 is the maximum concentration allowable for short exposures (0.5 to 1 hour) and 50 to 90 ppm is dangerous for short exposures. Therefore, 200 mg/m3 (24 ppm) is chosen as the IDLH for phosphorus pentachloride.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

Species Reference LC50 LCLo Time Adjusted 0.5-hrLC (CF) Derived value
Mouse Henderson & Haggard 1943 —– 1,020 mg/m3 10 min 704 mg/m3 (1.45) 70 mg/m3
Rat Molodkena 1973 205 mg/m3 —– ? ? ?

Lethal dose data:

Species Reference Route LD50(mg/kg) LDLo(mg/kg) Adjusted LD Derived value
Rat Molodkena 1973 oral 660 —– 4,620 mg/m3 462 mg/m3

Other data: The vapors of phosphorus pentachloride decompose in the presence of moisture with the subsequent liberation of hydrochloric and phosphoric acids [Henderson and Haggard 1943].

Human data: None relevant for use in determining the revised IDLH.

REFERENCES:

1. Henderson Y, Haggard HW [1943]. Noxious gases. 2nd ed. New York, NY: Reinhold Publishing Corporation, p. 134.

2. Molodkena NN [1973]. Toxicological comparisons of chlorine phosphate compounds (POCl3, PCl3, PCl5) by single and repeated exposures. Toksikol Nov Prom Khim Vesh 13:104 (in Russian).

Page last reviewed: December 4, 2014