Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 100–01–6
NIOSH REL: 3 mg/m3 TWA [skin]
Current OSHA PEL: 6 mg/m3 (1 ppm) TWA [skin]
1989 OSHA PEL: 3 mg/m3 TWA [skin]
1993-1994 ACGIH TLV: 3 mg/m3 TWA [skin]
Description of substance: Bright yellow, crystalline powder with a slight ammonia-like odor.
LEL: . . . Unknown
Original (SCP) IDLH: 300 mg/m3
Basis for original (SCP) IDLH: The chosen IDLH (300 mg/m3 or 50 ppm) is based on an analogy with aniline and the statement by AIHA  that 50 to 100 ppm aniline can probably be tolerated for 1 hour. Although the IDLH chosen for aniline was 100 ppm, the IDLH of 50 ppm (300 mg/m3) chosen for p-nitroaniline is reasonable because Von Oettingen  stated that p-nitroaniline is more toxic than aniline.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal dose data:
|Species||Reference||Route||LD50(mg/kg)||LDLo(mg/kg)||Adjusted LD||Derived value|
|Back et al. 1972Matrka et al. 1978
Vernot et al. 1977
|22,743 mg/m35,250 mg/m3
|2,274 mg/m3525 mg/m3
Human data: None relevant for use in determining the revised IDLH.
|Revised IDLH: 300 mg/m3 [Unchanged]Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for p-nitroaniline. Therefore, based on acute oral toxicity data in animals [Matrka et al. 1978; Moskalenko 1966; Vernot et al. 1977], the original IDLH for p-nitroaniline (300 mg/m3) is not being revised at this time.|
1. AIHA . Aniline. In: Hygienic guide series. Am Ind Hyg Assoc Q 16:331-332.
2 Back KC, Thomas AA, MacEwen JD . Reclassification of materials listed as transportation health hazards. Wright-Patterson Air Force Base, OH: 6570th Aerospace Medical Research Laboratory, Report No. TSA-20-72-3, pp. A-298 to A-299.
3. Matrka M, Rambousek V, Zverina Z . Toxicity of p-substituted derivatives of aniline in experimental rats. Ceskoslovenska Hygiena (Czechoslovak Hygiene) 23:168-172 (in Czechoslovakian).
4. Moskalenko EG . Toxicological characteristics of nitroanilines. Vop Komm Gig 6:89-94 (in Russian).
5. Vernot EH, MacEwen JD, Haun CC, Kinkead FR . Acute toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions. Toxicol Appl Pharmacol 42:417-423.
6. von Oettingen WF . The aromatic amino and nitro compounds, their toxicity and potential dangers. Public Health Bulletin 271:34.