Vanadium pentoxide (dust)
RTECS #
YW2450000
CAS #
Updated
April 2012
Molecular Weight
181.88
Molecular Formula
O5V2
Synonyms
Anhydride vanadique (French)
C.I. 77938
Divanandium pentoxide
RCRA waste number P120
Vanadic anhydride
Vanadio, pentossido di (Italian)
Vanadium (OSHA)
Vanadium oxide (V2O5)
Vanadium pentaoxide
Vanadium pentoxide
Vanadium pentoxide (ACGIH)
Vanadium, pentoxyde de (French)
Vanadiumpentoxid (German)
Vanadiumpentoxyde (Dutch)
Wanadu pieciotlenek (Polish)
C.I. 77938
Divanandium pentoxide
RCRA waste number P120
Vanadic anhydride
Vanadio, pentossido di (Italian)
Vanadium (OSHA)
Vanadium oxide (V2O5)
Vanadium pentaoxide
Vanadium pentoxide
Vanadium pentoxide (ACGIH)
Vanadium, pentoxyde de (French)
Vanadiumpentoxid (German)
Vanadiumpentoxyde (Dutch)
Wanadu pieciotlenek (Polish)
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 20 mg/24H | moderate | NTIS** OTS0534556 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| DNA Damage | leukocyte/human | 300 nmol/L | MUREAV 359,77,1996 |
| DNA Damage | lymphocyte/human | 30 µmol/L | MUREAV 359,77,1996 |
| DNA repair | /Bacillus subtilis | 500 mmol/L | MUREAV 77,109,1980 |
| micronucleus test | lung/hamster | 1 mg/L | MUREAV 321,35,1994 |
| sex chromosome loss and nondisjunction | lymphocyte/human | 10 nmol/L | MUREAV 386,291,1997 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/rat | 10 mg/kg (6-15D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Other developmental abnormalities | CHYCDW 20,189,1986 |
| intraperitoneal/rat | 10 mg/kg (6-15D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | HYDXET 24,92,1993 |
| intraperitoneal/rat | 50 mg/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Skin and skin appendages Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Other developmental abnormalities | HYDXET 24,202,1993 |
| intraperitoneal/rat | 5 mg/kg (10D pregnant) | Reproductive: Specific developmental abnormalities: Skin and skin appendages Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Other developmental abnormalities | HYDXET 24,202,1993 |
| intraperitoneal/mouse | 179 mg/kg (60D male) | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | 56ZJAL 4,423,1996 |
| intraperitoneal/mouse | 85 mg/kg (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Other developmental abnormalities | MSCREJ 21,711,1993 |
| intraperitoneal/mouse | 85 mg/kg (6-15D pregnant) | Reproductive: Other effects to embryo or fetus | MSCREJ 21,711,1993 |
| intraperitoneal/mouse | 170 mg/kg (60D male) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TCMUD8 16,7,1996 |
| intraperitoneal/mouse | 170 mg/kg (60D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | TCMUD8 16,7,1996 |
| intravenous/mouse | 10900 mg/kg (8D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | ENVRAL 33,47,1984 |
| oral/rat | 90 mg/kg (6-15D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetal death | CHYCDW 20,189,1986 |
| oral/rat | 180 mg/kg (6-15D pregnant) | Reproductive: Other effects to embryo or fetus | CHYCDW 20,189,1986 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/cat | Lowest published lethal concentration: 500 mg/m3/23M | 30ZIAO -,72,1964 | |
| inhalation/human | lowest published toxic concentration: 1 mg/m3/8H | Lung, Thorax, or Respiration: Cough | HBTME* -,905,2007 |
| inhalation/human | lowest published toxic concentration: 0.1 mg/m3/8H | Lung, Thorax, or Respiration: Sputum | HBTME* -,905,2007 |
| inhalation/human | lowest published toxic concentration: 10 mg/m3 | Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Dyspnea | HBTME* -,905,2007 |
| inhalation/human | lowest published toxic concentration: 346 mg/m3 | Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Sputum | AMIHAB 19,497,1959 |
| inhalation/human | lowest published toxic concentration: 1 mg/m3/8H | Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma Eye: Conjunctiva irritation | AEHLAU 14,709,1967 |
| inhalation/rat | lethal concentration (50 percent kill): 126 mg/m3/6H | Eye: Other eye effects Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea | NTIS** OTS0534556-1 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 23 mg/kg | TCMUD8 16,7,1996 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 12 mg/kg | ATXKA8 16,182,1956 | |
| intratracheal/rat | lethal dose (50 percent kill): 6 mg/kg | BCTKAG 11,191,1978 | |
| oral/mouse | lethal dose (50 percent kill): 5 mg/kg | GISAAA 26(10),6,1961 | |
| oral/rat | lethal dose (50 percent kill): 10 mg/kg | Behavioral: Coma | ATXKA8 16,182,1956 |
| skin/rabbit | lethal dose (50 percent kill): 50 mg/kg | Liver: Other changes Kidney, Ureter, and Bladder: Other changes | NTIS** OTS0534556 |
| subcutaneous/guinea pig | lowest published lethal dose: 20 mg/kg | 30ZIAO -,69,1964 | |
| subcutaneous/mouse | lethal dose (50 percent kill): 10 mg/kg | ZVKOA6 19,186,1974 | |
| subcutaneous/rat | lethal dose (50 percent kill): 14 mg/kg | Behavioral: Coma | ATXKA8 16,182,1956 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 3640 gm/m3/1W- intermittent | Lung, Thorax, or Respiration: Other changes Liver: Other changes Nutritional and Gross Metabolic: Changes in: Other metals | TXAPA9 197,274,2004 |
| inhalation/rat | lowest published toxic concentration: 100 µg/m3/24H/24D- continuous | Brain and Coverings: Recordings from specific areas of CNS Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | GISAAA 48(9),77,1983 |
| inhalation/rat | lowest published toxic concentration: 2 mg/m3/1H/13W- intermittent | Behavioral: Alteration of classical conditioning | GISAAA 22(3),25,1957 |
| inhalation/rat | lowest published toxic concentration: 60 µg/m3/4H/22W- intermittent | Liver: Fatty liver degeneration Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | WDZAEK 4,32,1990 |
| intraperitoneal/rat | lowest published toxic dose: 56 mg/kg/14D- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | TOLED5 11,119,1982 |
| intraperitoneal/rat | lowest published toxic dose: 40 mg/kg/4D- intermittent | Kidney, Ureter, and Bladder: Urine volume decreased or anuria Kidney, Ureter, and Bladder: Proteinuria Kidney, Ureter, and Bladder: Other changes in urine composition | WDZAEK 4,105,1990 |
| intratracheal/rat | lowest published toxic dose: 7200 µg/kg/1Y- intermittent | Lung, Thorax, or Respiration: Other changes Lung, Thorax, or Respiration: Changes in lung weight Biochemical: Metabolism (intermediary): Amino acids (including renal excretion) | BCTKAG 11,191,1978 |
| oral/rat | lowest published toxic dose: 91 mg/kg/26W- intermittent | Behavioral: Alteration of operant conditioning | GISAAA 26(10),6,1961 |
| oral/rat | lowest published toxic dose: 1280 mg/kg/15W- continuous | Blood: Pigmented or nucleated red blood cells Blood: Changes in erythrocyte (RBC) count Skin and Appendages: Other: Hair | AMIHBC 8,406,1953 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| TOXICOLOGY REVIEW | FRMBAZ 21,325,1973 | |
| TOXICOLOGY REVIEW | 85DHAX V,46,1974 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | ceiling concentration 0.5 mg/m3 | DTLVS* 3,275,1971 |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.05 mg/m3;KZW 0.25 mg/m3, resp, 2007 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.03 mg(V)/m3, MAY2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.2 mg(V)/m3, NOV2011 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0.05 mg/m3, MAC(short term exposure limit) 0.5 mg/m3, JAN1999 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | ceiling concentration 0.5 mg(V2O5)/m3, respirable fraction | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | ceiling concentration 0.5 mg(V2O5)/m3, respirable fraction | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | ceiling concentration 0.5 mg(V2O5)/m3, respirable dust | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | ceiling concentration 0.5 mg(V2O5)/m3, respirable fraction | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VANADIUM (as V2O5), resp dust/fume-air | ceiling concentration 0.05 mg/m3/15M | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 76210; Number of Industries 6; Total Number of Facilities 67; Number of Occupations 17; Total Number of Employees Exposed 4468; Total Number of Female Employees Exposed 541 | |
| National Occupational Hazard Survey 1974 | Hazard Code 76210; Number of Industries 7; Total Number of Facilities 333; Number of Occupations 12; Total Number of Employees Exposed 2562 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health