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Registry of Toxic Effects of Chemical Substances (RTECS)

Styrene, methyl-

RTECS #

WL5075000

CAS #

25013-15-4; 1321-45-5

Updated

October 2017

Molecular Weight

118.19

Molecular Formula

C9H10

Synonyms

3- and 4-Vinyl toluene (mixed isomers)
Ethenylmethylbenzene
Methylstyrene
Methylvinylbenzene
NCI-C56406
Toluene, vinyl- (mixed isomers)
Tolylethylene
Vinyl toluene
Vinyl toluene (ACGIH:OSHA)
Vinyl toluene (mixed isomers)
Vinyltoluene

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 90 mg mildAMIHAB 14,387,1956
skin /rabbit 100% moderateAMIHAB 14,387,1956

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testintraperitoneal/mouse200 mg/kgTOLED5 8,247,1981
mutation in mammalian somatic cellslymphocyte/mouse60 mg/LEMMUEG 12,85,1988

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 3750 mg/kg (1-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
SWEHDO 7(Suppl 4),66,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 400 ppmOlfaction: Other olfaction effects

Eye: Other eye effects
AMIHAB 14,387,1956
inhalation/mouse lowest published toxic concentration: 2 ppm/6MLung, Thorax, or Respiration: Respiratory depressionTOLED5 9,137,1981
inhalation/mouse lethal concentration (50 percent kill): 29500 mg/m3/4HVCVGH* -,207,1990
inhalation/mouse lethal concentration (50 percent kill): 3020 mg/m3/4HLung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Other changes

Blood: Hemorrhage
HYSAAV 34(7-9),334,1969
intraperitoneal/rat lethal dose (50 percent kill): 1038 mg/kgVCVGH* -,207,1990
intraperitoneal/rat lethal dose (16 percent kill): 747 mg/kgVCVGH* -,207,1990
intraperitoneal/rat lethal dose (84 percent kill): 1761 mg/kgVCVGH* -,207,1990
intraperitoneal/rat lethal dose (50 percent kill): 2324 mg/kgEye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair
ATDAEI 1,77,1990
oral/mouse lethal dose (50 percent kill): 3160 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Other changes

Blood: Hemorrhage
HYSAAV 34(7-9),334,1969
oral/rat lethal dose (50 percent kill): 2255 mg/kgEye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair
ATDAEI 1,77,1990
skin/mouse lowest published lethal dose: 4500 mg/kgGISAAA 34(9),40,1969
skin/rat lowest published lethal dose: 4500 mg/kgGISAAA 34(9),40,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 29 mg/m3/4H/16W- intermittentBehavioral: ExcitementNTIS** OTS0572508
inhalation/mouse lowest published toxic concentration: 200 ppm/6H/15D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Hepatitis (hepatocellular necrosis), diffuse

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-375,1990
inhalation/mouse lowest published toxic concentration: 160 ppm/6H/13W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-375,1990
inhalation/mouse lowest published toxic concentration: 618 mg/kg/103W- intermittentLung, Thorax, or Respiration: Tumors

Tumorigenic: Active as anti-cancer agent
NTIS** PB90-260035
inhalation/mouse lowest published toxic concentration: 618 mg/kg/103W- intermittentLiver: Tumors

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Active as anti-cancer agent
NTIS** PB90-260035
inhalation/mouse lowest published toxic concentration: 200 ppm/15D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Hepatitis (hepatocellular necrosis), zonal

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV132 -,-,2002
inhalation/mouse lowest published toxic concentration: 25 ppm/103W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV132 -,-,2002
inhalation/rat lowest published toxic concentration: 400 ppm/15D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV132 -,-,2002
inhalation/rat lowest published toxic concentration: 1300 ppm/15D- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Hepatitis (hepatocellular necrosis), zonal

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV132 -,-,2002
inhalation/rat lowest published toxic concentration: 1000 ppm/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes primarily in glomeruli
HPV132 -,-,2002
inhalation/rat lowest published toxic concentration: 5000 mg/m3/6H/100D- intermittentBlood: Hemorrhage

Blood: Luekopenia

Blood: Changes in leukocyte (WBC) count
VCVGH* -,207,1990
inhalation/rat lowest published toxic concentration: 1300 ppm/6H/15D- intermittentEye: Lacrimation

Liver: Other changes

Liver: Changes in liver weight
NTPTR* NTP-TR-375,1990
inhalation/rat lowest published toxic concentration: 332 ppm/6H/21W- intermittentPeripheral Nerve and Sensation: Recording from afferent nerve

Peripheral Nerve and Sensation: Recording from peripheral motor nerve
TOLED5 30,27,1986
inhalation/rat lowest published toxic concentration: 1000 ppm/6H/13W- intermittentEye: Lacrimation

Liver: Changes in liver weight
NTPTR* NTP-TR-375,1990
inhalation/rat lowest published toxic concentration: 100 ppm/6H/15W- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveATSUDG 5,100,1982

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 50 ppm;short term exposure limit 100 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 60,373,1994
International Agency for Research on Cancer (IARC)Cancer Review:Animal Lack CarcinogenicityIMEMDT 60,373,1994
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 60,373,1994
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWTOLED5 204,148,2011
TOXICOLOGY REVIEWMUREAV 802,1,I2

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 100 ppm (480 mg/m3)DTLVS* 3,278,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 50 ppm (242 mg/m3), short term exposure limit 100 ppm (483 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 100 ppm (480 mg/m3);KZW 100 ppm (480 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 50 ppm (246 mg/m3), short term exposure limit 100 ppm(490 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 25 ppm (120 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 10 ppm (49 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 50 ppm (240 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 100 ppm (490 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 25 ppm (120 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 50 ppm (240 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 50 ppm (240 mg/m3);short term exposure limit 100 ppm (485 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 50 ppm (242 mg/m3), short term exposure limit 100 ppm (483 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 50 ppm (242 mg/m3); short term exposure limit 100 ppm (483 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 300 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 50 mg/m3, short term exposure limit 150 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (50 mg/m3);short term exposure limit 30 ppm (150 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 50 ppm (240 mg/m3), KZG-week 100 ppm (480 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 50 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 100 ppm (480 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 100 ppm (480 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 100 ppm (480 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 100 ppm (480 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 100 ppm (480 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 100 ppm (480 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYL TOLUENE-air10H time-weighted average 100 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 76510; Number of Industries 24; Total Number of Facilities 2028; Number of Occupations 31; Total Number of Employees Exposed 25353; Total Number of Female Employees Exposed 3889
National Occupational Hazard Survey 1974Hazard Code 76510; Number of Industries 61; Total Number of Facilities 7016; Number of Occupations 59; Total Number of Employees Exposed 73140

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat
NIOSH Analytical Method, 1994: Hydrocarbons, aromatic, 1501
On EPA IRIS database
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