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Registry of Toxic Effects of Chemical Substances (RTECS)

Pyridine, 2-chloro-6-(trichloromethyl)-

RTECS #

US7525000

CAS #

1929-82-4

Updated

September 2013

Molecular Weight

230.90

Molecular Formula

C6H3Cl4N

Synonyms

2-Chloro-6-(trichloromethyl)pyridine
2-Chloro-6-(trichloromethyl)pyridine (ACGIH:OSHA)
Dowco-163
Nitrapyrin
Nitrapyrin (ACGIH)
N-Serve
N-Serve nitrogen stabilizer

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium100 µg/plate (-enzymatic activation step)EMMUEG 11(Suppl 12),1,1988

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rabbit 390 mg/kg (6-18D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)FAATDF 11,464,1988

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/chicken lethal dose (50 percent kill): 235 mg/kg28ZEAL 5,166,1976
oral/mouse lethal dose (50 percent kill): 710 mg/kgGUCHAZ 6,122,1973
oral/rabbit lethal dose (50 percent kill): 713 mg/kgFAATDF 11,464,1988
oral/rat lethal dose (50 percent kill): 940 mg/kgPCOC** -,819,1966
skin/rabbit lethal dose (50 percent kill): 850 mg/kgPCOC** -,819,1966
unreported route/mouse lethal dose (50 percent kill): 3113 mg/kgGISAAA 48(4),52,1983
unreported route/rat lethal dose (50 percent kill): 3675 mg/kgGISAAA 48(4),52,1983

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 mg/m3;short term exposure limit 20 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWDOEAAH 32,22,1976
TOXICOLOGY REVIEWFEREAC 72,53455,2007
TOXICOLOGY REVIEWRTOPDW 51,53,2008

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,137,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, MAR2002
Occupational Exposure Limit-FRANCEVME 10 mg/m3, FEB2006
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3, short term exposure limit 20 ppm, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 10 mg/m3; short term exposure limit 20 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 mg/m3, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL, respirable fraction-air10H time-weighted average 5 mg/m3NIOSH* DHHS #95-121,1995
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air10H time-weighted average 10 mg/m3;short term exposure limit 20 mg/m3NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code X3196; Number of Industries 1; Total Number of Facilities 12; Number of Occupations 3; Total Number of Employees Exposed 399

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
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