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Registry of Toxic Effects of Chemical Substances (RTECS)

Propene, 3-chloro-

RTECS #

UC7350000

CAS #

107-05-1

Updated

December 2015

Molecular Weight

76.53

Molecular Formula

C3H5Cl

Synonyms

1-Chloro propene-2
1-Chloro-2-propene
1-Propene, 3-chloro-
2-Propenyl chloride
3-Chloro-1-propylene
3-Chloroprene
3-Chloropropene
3-Chloropropene-1
3-Chloropropylene
3-Chlorpropen (German)
Allile (cloruro di) (Italian)
Allyl chloride
Allyl chloride (ACGIH:OSHA)
Allylchlorid (German)
Allyle (chlorure d') (French)
alpha-Chloropropylene
Chlorallylene
Chloroallylene
NCI-C04615
p-Aminopropiofenon (Czech)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /guinea pig 290 ppm/6HJIHTAB 22,79,1940
eye /rabbit 500 mg moderateAJOPAA 29,1363,1946
eye /rat 290 ppm/6HJIHTAB 22,79,1940
skin /rabbit 10 mg/24H open irritation testJIHTAB 30,63,1948

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA repair/Escherichia coli9380 µg/plateMUREAV 57,11,1978
gene conversion and mitotic recombination/Saccharomyes cerevisiae184 µmol/LMUREAV 57,11,1978
mutation in microorganisms/Salmonella typhimurium250 µg/plate/72H (-enzymatic activation step)TOXID9 228,66,2006
mutation in microorganisms/Salmonella typhimurium250 µg/plate/72H (+enzymatic activation step)TOXID9 228,66,2006
mutation in microorganisms/Other microorganisms9380 µg/plate (-enzymatic activation step)CBINA8 30,9,1980
mutation in microorganisms/Salmonella typhimurium938 µg/plate (+enzymatic activation step)MUREAV 57,11,1978
mutation in microorganisms/Escherichia coli20 µL/plate (-enzymatic activation step)MUREAV 153,57,1985
Unscheduled DNA SynthesisHeLa cell/human1 mmol/LCALEDQ 20,263,1983

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 300 ppm/7H (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemFAATDF 3,437,1983
intraperitoneal/rat 1200 mg/kg (1-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities
SWEHDO 7(Suppl 4),66,1981
oral/mouse 4 gm/kg (7-14D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathNTIS** PB86-197605

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 5880 mg/kg/8W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CNREA8 39,391,1979
oral/mouse toxic dose: 78 gm/kg/78W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
NCITR* NCI-TR-73,1978
oral/mouse lowest published toxic dose: 50 gm/kg/78W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
NCITR* NCI-TR-73,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 10500 mg/m3/2HBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
EESADV 6,19,1982
inhalation/guinea pig lowest published toxic concentration: 1000 mg/m3/2HBehavioral: General anestheticVCVGH* -,467,1990
inhalation/guinea pig lethal concentration (50 percent kill): 5800 mg/m3/2HEye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
EESADV 6,19,1982
inhalation/guinea pig Lowest published lethal concentration: 10000 mg/m3/4HVCVGH* -,467,1990
inhalation/human Lowest published lethal concentration: 3000 ppm34ZIAG -,86,1969
inhalation/mouse lethal concentration (50 percent kill): 11500 mg/m3/2HEye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
EESADV 6,19,1982
inhalation/mouse lethal concentration (16 percent kill): 5000 mg/m3VCVGH* -,467,1990
inhalation/mouse lethal concentration (50 percent kill): 6600 mg/m3VCVGH* -,467,1990
inhalation/mouse Lowest published lethal concentration: 8100 mg/m3VCVGH* -,467,1990
inhalation/mouse lethal concentration (84 percent kill): 8600 mg/m3VCVGH* -,467,1990
inhalation/rabbit Lowest published lethal concentration: 22500 mg/m3/2HEye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
EESADV 6,19,1982
inhalation/rat lethal concentration (50 percent kill): 11 gm/m3/2HEye: Lacrimation

Gastrointestinal: Ulceration or bleeding from duodeum

Lung, Thorax, or Respiration: Respiratory depression
EESADV 6,19,1982
inhalation/rat lethal concentration (16 percent kill): 6400 mg/m3VCVGH* -,467,1990
inhalation/rat lethal concentration (50 percent kill): 8200 mg/m3VCVGH* -,467,1990
inhalation/rat lethal concentration (84 percent kill): 10000 mg/m3VCVGH* -,467,1990
inhalation/rat lowest published toxic concentration: 1000 mg/m3/2HBehavioral: General anestheticVCVGH* -,467,1990
inhalation/rat Lowest published lethal concentration: 20000 mg/m3/2HVCVGH* -,467,1990
inhalation/rat Lowest published lethal concentration: 10000 mg/m3/4HVCVGH* -,467,1990
intraperitoneal/mouse lethal dose (50 percent kill): 155 mg/kgSCCUR* -,1,1961
oral/mouse lethal dose (50 percent kill): 425 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea
EESADV 6,19,1982
oral/mouse lethal dose (50 percent kill): 500 mg/kgVCVGH* -,468,1990
oral/rabbit lethal dose (50 percent kill): 300 mg/kgVCVGH* -,468,1990
oral/rat lethal dose (50 percent kill): 450 mg/kgVCVGH* -,468,1990
oral/rat lethal dose (50 percent kill): 460 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
EESADV 6,19,1982
skin/rabbit lethal dose (50 percent kill): 2066 mg/kgJIHTAB 30,63,1948

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 8 ppm/7H/35D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
AIHAAP 20,217,1959
inhalation/rabbit lowest published toxic concentration: 206 mg/m3/6H/13W- intermittentPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Peripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Muscle weakness
EESADV 6,19,1982
inhalation/rabbit lowest published toxic concentration: 8 ppm/7H/35D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
AIHAAP 20,217,1959
inhalation/rabbit lowest published toxic concentration: 206 mg/m3/6H/13W- intermittentSpinal Cord: Demyelination

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Muscle weakness
EESADV 6,19,1982
inhalation/rabbit lowest published toxic concentration: 25 mg/m3/8H/75D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGH* -,469,1990
inhalation/rat lowest published toxic concentration: 400 mg/m3/4W- continuousLung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGH* -,470,1990
inhalation/rat lowest published toxic concentration: 1.1 mg/m3/16W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainVCVGH* -,469,1990
inhalation/rat lowest published toxic concentration: 9 mg/m3/180D- continuousKidney, Ureter, and Bladder: Changes primarily in glomeruli

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Liver: Other changes
VCVGH* -,469,1990
inhalation/rat lowest published toxic concentration: 25 mg/m3/8H/75D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGH* -,469,1990
inhalation/rat lowest published toxic concentration: 8 ppm/7H/35D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Endocrine: Changes in spleen weight
AIHAAP 20,217,1959
inhalation/rat lowest published toxic concentration: 250 ppm/6H/90D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes
NTIS** OTS0539130
oral/mouse lowest published toxic dose: 15300 mg/kg/17W- intermittentSpinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Structural change in nerve or sheath
ANPTAL 55,125,1981
oral/rat : 3600 mg/kg/6W- intermittentBehavioral: Change in motor activity (specific assay)

Behavioral: Muscle weakness

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
TOXID9 227,36,2006
oral/rat : 1800 mg/kg/3W- intermittentBiochemical: Metabolism (intermediary): Lipids including transportTOXID9 227,36,2006
oral/rat lowest published toxic dose: 3600 mg/kg/6W- intermittentBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Behavioral: Muscle weakness
TXCYAC 231,58,2007
subcutaneous/rat lowest published toxic dose: 5100 mg/kg/12W- intermittentBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 191,33,2003
subcutaneous/rat lowest published toxic dose: 9949 mg/kg/13W- intermittentSpinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Peripheral Nerve and Sensation: Recording from peripheral motor nerve
ENVRAL 63,229,1993
subcutaneous/rat lowest published toxic dose: 1350 mg/kg/9D- intermittentPeripheral Nerve and Sensation: Structural change in nerve or sheath

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Ca
ZYYZEW 3,293,1989

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 ppm;short term exposure limit 2 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 36,39,1985
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 71,1231,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 36,39,1985
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 71,1231,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1231,1999
TOXICOLOGY REVIEWEVHPAZ 21,251,1977
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWFCTOD7 55,596,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 ppm (3 mg/m3)DTLVS* 3,8,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 ppm (3 mg/m3), short term exposure limit 2 ppm (6 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1 ppm (3 mg/m3);KZW 1 ppm (3 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 ppm (3 mg/m3), short term exposure limit 2 ppm (6 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 ppm (3 mg/m3), carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1 ppm (3.2 mg/m3), short term exposure limit 3 ppm (9.5 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 1 ppm (3 mg/m3), C3 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 3 mg/m3, short term exposure limit 3 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 1 ppm (3 mg/m3), NOV2011
Occupational Exposure Limit-INDIAtime-weighted average 1 ppm (3 mg/m3), short term exposure limit 2 ppm (6 mg/m3), JAN1993
Occupational Exposure Limit-KOREAtime-weighted average 1 ppm (3 mg/m3), short term exposure limit 2 ppm (6 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1 ppm (3 mg/m3);short term exposure limit 2 ppm, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 ppm (3 mg/m3); short term exposure limit 2 ppm (6 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1 ppm (3.1 mg/m3); short term exposure limit 2 ppm (6.2 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 ppm (3 mg/m3);short term exposure limit 3 ppm (9 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 1 ppm (3 mg/m3), carc 3, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 3 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1 ppm (3 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1 ppm (3 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1 ppm (3 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1 ppm (3 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ALLYL CHLORIDE-air10H time-weighted average 1 ppm;short term exposure limit 3 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X3205; Number of Industries 10; Total Number of Facilities 159; Number of Occupations 15; Total Number of Employees Exposed 3193; Total Number of Female Employees Exposed 325

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (gavage);equivocal evidence:mouseNCITR* NCI-TR-73,1978
NCI Carcinogenesis Bioassay (gavage);no evidence:ratNCITR* NCI-TR-73,1978
NIOSH Analytical Method, 1994: Allyl chloride, 1000
On EPA IRIS database
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