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Registry of Toxic Effects of Chemical Substances (RTECS)

Propane, 2,2'-oxybis-

RTECS #

TZ5425000

CAS #

108-20-3

Updated

April 2015

Molecular Weight

102.20

Molecular Formula

C6H14O

Synonyms

2-Isopropoxypropane
Diisopropyl oxide
Ether isopropylique (French)
Ether, isopropyl
Isopropyl ether
Isopropyl ether (ACGIH:OSHA)
Izopropylowy eter (Polish)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 363 mg open irritation test mildUCDS** 4/10/1968

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 3095 ppm/6H (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JTEHD6 49,29,1996
inhalation/rat 10000 mg/m3 (10D prior to copulation)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)VCVGK* -,266,1994
inhalation/rat 3095 ppm (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
HPV206 -,-,2005
inhalation/rat 3095 ppm (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV376 -,-,2006

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 6 pphBehavioral: General anesthetic

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,266,1994
inhalation/guinea pig Lowest published lethal concentration: 60000 ppm/1HBehavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression
HPV206 -,-,2005
inhalation/guinea pig lowest published toxic concentration: 1 pphBehavioral: General anestheticHPV376 -,-,2006
inhalation/guinea pig Lowest published lethal concentration: 6 pphBehavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression
HPV376 -,-,2006
inhalation/human lowest published toxic concentration: 500 ppmOlfaction: Other olfaction effectsHPV376 -,-,2006
inhalation/human lowest published toxic concentration: 1250 mg/m3/3MEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,267,1994
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 130 gm/m3GTPZAB 32(10),25,1988
inhalation/monkey Lowest published lethal concentration: 6 pphBehavioral: General anesthetic

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,266,1994
inhalation/monkey Lowest published lethal concentration: 6 pphBehavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression
HPV376 -,-,2006
inhalation/monkey lowest published toxic concentration: 1 pphBehavioral: General anestheticHPV376 -,-,2006
inhalation/monkey Lowest published lethal concentration: 60000 ppm/1HBehavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression
HPV206 -,-,2005
inhalation/mouse lethal concentration (50 percent kill): 130800 mg/m3Behavioral: General anesthetic

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,266,1994
inhalation/mouse lethal concentration (50 percent kill): 131 gm/m3Behavioral: General anesthetic

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity
GTPZAB 19(10),55,1975
inhalation/rabbit lethal concentration (50 percent kill): 121 gm/m3Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity
GTPZAB 19(10),55,1975
inhalation/rabbit Lowest published lethal concentration: 6 pphBehavioral: General anesthetic

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,266,1994
inhalation/rabbit Lowest published lethal concentration: 60000 ppm/1HBehavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression
HPV206 -,-,2005
inhalation/rabbit lowest published toxic concentration: 1 pphBehavioral: General anestheticHPV376 -,-,2006
inhalation/rabbit Lowest published lethal concentration: 6 pphBehavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression
HPV376 -,-,2006
inhalation/rabbit lethal concentration (50 percent kill): 120600 mg/m3Behavioral: General anesthetic

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,266,1994
inhalation/rat lethal concentration (50 percent kill): 161700 mg/m3Behavioral: General anesthetic

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,266,1994
inhalation/rat lowest published toxic concentration: 500 ppm/6HLung, Thorax, or Respiration: Other changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 90,374,2006
inhalation/rat lethal concentration (50 percent kill): 162 gm/m3Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity
GTPZAB 19(10),55,1975
intraperitoneal/mouse lethal dose (50 percent kill): 812 mg/kgSCCUR* -,5,1961
oral/mammal (species unspecified) lethal dose (50 percent kill): 6 gm/kgGTPZAB 32(10),25,1988
oral/mouse lethal dose (50 percent kill): 3600 mg/kgVCVGK* -,266,1994
oral/rabbit lowest published lethal dose: 5 gm/kgBehavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression
HPV206 -,-,2005
oral/rabbit lowest published lethal dose: 6 gm/kgBehavioral: Altered sleep time (including change in righting reflex)JIHTAB 21(3),72,1939
oral/rabbit lowest published lethal dose: 5 gm/kgBehavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease
HPV376 -,-,2006
oral/rat lethal dose (50 percent kill): 4.5 gm/kgHPV376 -,-,2006
skin/rabbit lethal dose (50 percent kill): >2 gm/kgHPV376 -,-,2006
skin/rabbit lethal dose (50 percent kill): 20 mL/kgUCDS** 4/10/1968
unreported route/mouse lethal dose (50 percent kill): 3600 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity
GTPZAB 19(10),55,1975
unreported route/rat lethal dose (50 percent kill): 5880 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity
GTPZAB 19(10),55,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit lowest published toxic concentration: 2090 mg/m3/5H/22W- intermittentBehavioral: Muscle contraction or spasticity

Liver: Liver function tests impaired
GTPZAB 19(10),55,1975
inhalation/rabbit lowest published toxic concentration: 2090 mg/m3/5H/152D- intermittentCardiac: Other changes

Lung, Thorax, or Respiration: Emphysema

Blood: Changes in spleen
VCVGK* -,267,1994
inhalation/rabbit lowest published toxic concentration: 507 mg/m3/5H/152D- intermittentLiver: Multiple effectsVCVGK* -,267,1994
inhalation/rat lowest published toxic concentration: 500 ppm/5D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 90,374,2006
inhalation/rat lowest published toxic concentration: 7100 ppm/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight
HPV206 -,-,2005
inhalation/rat lowest published toxic concentration: 3300 ppm/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
HPV376 -,-,2006
inhalation/rat lowest published toxic concentration: 450 ppm/13W- intermittentBehavioral: Change in motor activity (specific assay)HPV376 -,-,2006
inhalation/rat lowest published toxic concentration: 7500 mg/m3/30D- intermittentBehavioral: Irritability

Brain and Coverings: Increased intracranial pressure
VCVGK* -,266,1994
inhalation/rat lowest published toxic concentration: 10000 mg/m3/4H/10D- intermittentEndocrine: Effect on menstrual cycle

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
VCVGK* -,266,1994
inhalation/rat lowest published toxic concentration: 2090 mg/m3/5H/152D- intermittentBrain and Coverings: Other degenerative changes

Liver: Liver function tests impaired
VCVGK* -,267,1994
inhalation/rat lowest published toxic concentration: 2090 mg/m3/5H/22W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Blood: Other changes
GTPZAB 19(10),55,1975
inhalation/rat lowest published toxic concentration: 3300 ppm/6H/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
JTEHD6 49,29,1996

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 250 ppm;short term exposure limit 310 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWENTOX* -,387,2005
TOXICOLOGY REVIEWMUREAV 762,76,2014

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 250 ppm (1050 mg/m3)DTLVS* 3,142,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 250 ppm (1040 mg/m3), short term exposure limit 310 ppm (1300 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 250 ppm (1050 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 250 ppm (1055 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 310 ppm (1319 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 250 ppm (1050 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 250 ppm, short term exposure limit 320 ppm, NOV2011
Occupational Exposure Limit-FRANCEVME 250 ppm (1050 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 200 ppm (850 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 250 ppm (1050 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 250 ppm (1025 mg/m3), short term exposure limit 310 ppm (1320 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 250 ppm (1050 mg/m3);short term exposure limit 310 ppm (1320 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 250 ppm (1040 mg/m3); short term exposure limit 310 ppm (1300 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 125 ppm (525 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 250 ppm (1047 mg/m3); short term exposure limit 310 ppm (1298 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1000 mg/m3, MAC(short term exposure limit) 1300 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 100 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 200 ppm (850 mg/m3), KZG-week 400 ppm (1700 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1050 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 500 ppm (2100 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 250 ppm (1060 mg/m3);short term exposure limit 310 ppm (1310 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 500 ppm (2100 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 500 ppm (2100 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 500 ppm (2100 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 500 ppm (2100 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOPROPYL ETHER-air10H time-weighted average 500 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 25905; Number of Industries 5; Total Number of Facilities 130; Number of Occupations 11; Total Number of Employees Exposed 3253; Total Number of Female Employees Exposed 1126
National Occupational Hazard Survey 1974Hazard Code 25905; Number of Industries 11; Total Number of Facilities 952; Number of Occupations 11; Total Number of Employees Exposed 12024

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Isopropyl ether, 1618
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