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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorothioic acid, O,O-diethyl O-(p-(methylsulfinyl)phenyl) ester

RTECS #

TF3850000

CAS #

115-90-2

Updated

December 2015

Molecular Weight

308.37

Molecular Formula

C11H17O4PS2

Synonyms

BAY 25141
Bayer 25141
Chemagro 25141
Daconit
Dasanit
ENT 24,945
Fensulfothion
Fensulfothion (ACGIH)
O,O-Diaethyl-O-(4-methylsulfinyl-phenyl)-thionophosphat (German)
O,O-Diaethyl-O-4-methylsulfinyl-phenyl-monothiophosphat (German)
O,O-Diethyl O-(p-(methylsulfinyl)phenyl) phosphorothioate
O,O-Diethyl O-p-(methylsulfinyl)phenyl thiophosphate
OMS 37
Phenol, p-(methylsulfinyl)-, O-ester with O,O-diethyl phosphorothioate
S 767
Terracur P
VUAgT 108
VUAgT 96

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 113 mg/m3/1H85JFAN A202,1983
intracerebral/mouse lethal dose (50 percent kill): 2 mg/kgPCBPBS 8,302,1978
intraperitoneal/guinea pig lethal dose (50 percent kill): 5400 µg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 6,78,1964
intraperitoneal/mouse lethal dose (50 percent kill): 7 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 6,78,1964
intraperitoneal/rat lethal dose (50 percent kill): 1500 µg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 6,78,1964
oral/duck lethal dose (50 percent kill): 747 µg/kgTXAPA9 22,556,1972
oral/guinea pig lethal dose (50 percent kill): 9 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 6,78,1964
oral/pigeon lethal dose (50 percent kill): 560 µg/kgASTTA8 (680),157,1979
oral/quail lethal dose (50 percent kill): 1200 µg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
EESADV 8,551,1984
oral/rat lethal dose (50 percent kill): 2200 µg/kgTXAPA9 6,78,1964
oral/wild bird lethal dose (50 percent kill): 240 µg/kgTXAPA9 21,315,1972
skin/duck lethal dose (50 percent kill): 3 mg/kgTXAPA9 47,451,1979
skin/rat lethal dose (50 percent kill): 3 mg/kgWRPCA2 9,119,1970
skin/wild bird lethal dose (50 percent kill): 420 µg/kgTXAPA9 26,154,1973
unreported route/rat lethal dose (50 percent kill): 11 mg/kg30ZDA9 -,337,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 30 mg/kg/60D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTXAPA9 6,78,1964

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWTOLED5 230,434,2014

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,120,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 mg/m3;KZW 0.2 mg/m3, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.01 mg/m3, Skin, MAR2002
Occupational Exposure Limit-FRANCEVME 0.1 mg/m3, FEB2006
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,1 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FENSULFOTHION-air10H time-weighted average 0.1 mg/m3NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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