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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphoric acid, dibutyl ester

RTECS #

TB9605000

CAS #

107-66-4

Updated

September 2013

Molecular Weight

210.24

Molecular Formula

C8H19O4P

Synonyms

Dibutyl acid phosphate
Dibutyl hydrogen phosphate
Dibutyl phosphate
Dibutyl phosphate (ACGIH:OSHA)
Di-n-butyl phosphate
DP 4 (coupling agent)
HDBP

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL severeHPV341 -,-,2001
skin /rabbit 500 µL/8H severeHPV341 -,-,2001

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 39000 mg/kg (14D pre-3D after birth)Reproductive: Other effects on female

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
HPV341 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/rat lethal dose (50 percent kill): 3200 mg/kgHPV341 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 4400 mg/kg/44D- continuousBehavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder
HPV341 -,,2001
oral/rat lowest published toxic dose: 13200 mg/kg/44D- continuousBehavioral: Food intake (animal)

Gastrointestinal: Ulceration or bleeding from stomach

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder
HPV341 -,,2001
oral/rat lowest published toxic dose: 44000 mg/kg/44D- continuousGastrointestinal: Ulceration or bleeding from stomach

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV341 -,,2001
oral/rat lowest published toxic dose: 39000 mg/kg/39D- continuousGastrointestinal: Gastritis

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV341 -,,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg/m3 (inhal, vapor)DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 ppm (5 mg/m3)DTLVS* 3,75,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 ppm (8.6 mg/m3), short term exposure limit 2 ppm (17 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.6 ppm (5 mg/m3);KZW 1.2 ppm (10 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 ppm (8.7 mg/m3), short term exposure limit 2 ppm (17 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 ppm (8.6 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1 ppm (8.7 mg/m3), short term exposure limit 3 ppm (26 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 1 ppm (5 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 1 ppm (8.6 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 1 ppm (5 mg/m3), short term exposure limit 2 ppm (10 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1 ppm (5 mg/m3);short term exposure limit 2 ppm (10 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 ppm (8.6 mg/m3); short term exposure limit 2 ppm (17 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1 ppm (8,6 mg/m3); short term exposure limit 2 ppm (17,2 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1 ppm (8.5 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1 ppm (5 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 ppm (8.7 mg/m3);short term exposure limit 2 ppm (17 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1 ppm (5 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1 ppm (5 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1 ppm (5 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1 ppm (5 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIBUTYL PHOSPHATE-air10H time-weighted average 1 ppm;short term exposure limit 2 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 23865; Number of Industries 2; Total Number of Facilities 76; Number of Occupations 2; Total Number of Employees Exposed 1321
National Occupational Hazard Survey 1974Hazard Code 23865; Number of Industries 1; Total Number of Facilities 13; Number of Occupations 1; Total Number of Employees Exposed 13

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Dibutyl phosphate, 5017
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