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Registry of Toxic Effects of Chemical Substances (RTECS)

1,2-Oxathiolane 2,2-dioxide

RTECS #

RP5425000

CAS #

1120-71-4

Updated

April 2017

Molecular Weight

122.15

Molecular Formula

C3H6O3S

Synonyms

1,3-Propane sultone
1-Propanesulfonic acid-3-hydroxy-gamma-sultone
3-Hydroxy-1-propanesulfonic acid gamma-sultone
3-Hydroxy-1-propanesulphonic acid sultone
gamma-Propane sultone
Propane sultone
Propane sultone (ACGIH)
Propanesultone
RCRA waste number U193

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg mild34ZIAG -,498,1969

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human1 mmol/LTOLED5 28,139,1985
Cytogenetic Analysisfibroblast/hamster125 mg/L/24HMUREAV 48,337,1977
Cytogenetic Analysislung/hamster10 mg/LATSUDG 4,41,1980
DNA adduct/Escherichia coli10 µmol/LMUREAV 89,95,1981
DNA Damage/Bacillus subtilis50 nmol/LCNREA8 41,4368,1981
DNA Damagefibroblast/human5 mg/LCBINA8 22,185,1978
DNA Damagemammary gland/human10 mg/L/24H (-enzymatic activation step)MUREAV 588,47,2005
DNA Damageintraperitoneal/mouse200 mg/kgMUREAV 467,83,2000
DNA Damageintravenous/rat31 mg/kgTCMUD8 7,175,1987
DNA inhibitionskin/mouse2 mmol/kgCNREA8 33,769,1973
DNA inhibitionoral/mouse20 gm/kgARGEAR 51,605,1981
DNA repair/Other microorganisms610 µg/plateBIZNAT 95,463,1976
DNA repair/Escherichia coli500 µg/discJJIND8 62,873,1979
gene conversion and mitotic recombination/Saccharomyes cerevisiae1000 ppmJJIND8 62,901,1979
host-mediated assaySalmonella typhimurium/mouse12 mg/kgJJIND8 62,911,1979
micronucleus testintraperitoneal/mouse18 mg/kg/48H- intermittentMUREAV 389,3,1997
morphological transformfibroblast/mouse30 µg/LCRNGDP 3,377,1982
morphological transformembryo/mouse50 mg/LTOLED5 9,301,1981
morphological transformintraperitoneal/hamster1 gm/kgARPAAQ 95,380,1973
morphological transformkidney/hamster80 µg/LBJCAAI 37,873,1978
morphological transformembryo/hamster1 mg/LIJCNAW 19,642,1977
morphological transformembryo/rat5 mg/LJNCIAM 51,799,1973
morphological transformother cell types/human7500 µg/LCNREA8 41,5096,1981
mutation in mammalian somatic cellsfibroblast/human30 mg/LCNREA8 41,1620,1981
mutation in microorganisms/Schizosaccharomyces pombe7900 µmol/L (-enzymatic activation step)CBINA8 14,195,1976
mutation in microorganisms/Escherichia coli1 gm/L (-enzymatic activation step)ATXKA8 28,93,1971
mutation in microorganisms/Salmonella typhimurium5 µg/plate (+enzymatic activation step)JJIND8 62,893,1979
mutation in microorganisms/Salmonella typhimurium70 µg/plate (-enzymatic activation step)PNASA6 72,5135,1975
mutation in microorganisms/Serratia marcescens25 mg/L (-enzymatic activation step)ATXKA8 30,67,1972
mutation in microorganisms/Other microorganisms1600 mg/L (-enzymatic activation step)MOPMA3 6,667,1970
other mutation test systems/Bacillus subtilis50 mmol/LJOBAAY 136,854,1978
other mutation test systems/Salmonella typhimurium16 mg/LMUREAV 192,239,1987
sister chromatid exchangelymphocyte/human500 µmol/LTOLED5 28,139,1985
specific locus testoral/rat420 mg/kg/14D- intermittentMUREAV 721,163,2011
specific locus testoral/rat240 mg/kg/3DMUREAV 782,24,2015
Unscheduled DNA Synthesisskin/mouse2 mmol/kgCNREA8 33,769,1973
Unscheduled DNA Synthesisfibroblast/human200 µmol/L/2H33AQAA -,103,1976

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intravenous/rat 80 mg/kg (15D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathIARCCD 4,45,1973

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intravenous/rat lowest published toxic dose: 20 mg/kg (15D pregnant)Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Brain and Coverings: Tumors
IARCCD 4,45,1973
oral/rat lowest published toxic dose: 7840 mg/kg/60W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors

Skin and Appendages: Tumors
NATUAS 230,460,1971
oral/rat toxic dose: 1100 mg/kg/37W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Peripheral Nerve and Sensation: Peripheral nerve tumors
ZEKBAI 75,69,1970
oral/rat toxic dose: 12 gm/kg/60W- continuousTumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors

Skin and Appendages: Tumors
JJIND8 67,75,1981
oral/rat toxic dose: 13 gm/kg/32W- continuousTumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors

Skin and Appendages: Tumors
JJIND8 67,75,1981
skin/mouse lowest published toxic dose: 1000 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease
TXCYAC 6,139,1976
skin/mouse toxic dose: 50 mg/kg/1W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
TXAPA9 37,93,1976
subcutaneous/mouse lowest published toxic dose: 756 mg/kg/63W- intermittentTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
JNCIAM 46,143,1971
subcutaneous/rat lowest published toxic dose: 10 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
ZEKBAI 75,69,1970
subcutaneous/rat toxic dose: 166 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
INTSAO 66,161,1981
subcutaneous/rat toxic dose: 559 mg/kg/17W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
INTSAO 66,161,1981
subcutaneous/rat toxic dose: 434 mg/kg/15W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
INTSAO 66,161,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 2140 mg/m3/6HEye: Lacrimation

Vascular: Regional or general arteriolar or venous dilation

Skin and Appendages: Other: Hair
NTIS** OTS0555330
intraperitoneal/mouse lethal dose (50 percent kill): 100 mg/kgEye: Other eye effects

Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair
NTIS** OTS0555330
intraperitoneal/rat lethal dose (50 percent kill): 100 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea
NTIS** OTS0555330
oral/mouse lethal dose (50 percent kill): 400 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Skin and Appendages: Other: Hair
NTIS** OTS0555330
oral/rat lethal dose (50 percent kill): 100 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea
NTIS** OTS0555330
skin/mouse lowest published lethal dose: 1000 gm/kgTXCYAC 6,139,1976
subcutaneous/rat lethal dose (50 percent kill): 135 mg/kgZEKBAI 75,69,1970

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Control as low as possible (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 4,253,1974
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,1095,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 4,253,1974
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1095,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 71,1095,1999
TOXICOLOGY REVIEWTOLED5 151,251,2004
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 783,23,2015
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWMUREAV 802,1,2016

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIACarcinogen, JUL2008
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-SWEDENGroup B Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDcarc 2, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPANE SULTONE-airCarcinogen lowest feasible concentrationNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
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