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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Naphthylamine

RTECS #

QM2100000

CAS #

91-59-8

Updated

June 2017

Molecular Weight

143.20

Molecular Formula

C10H9N

Synonyms

2-Aminonaftalen (Czech)
2-Aminonaphthalene
2-AN
2-Naftylamin (Czech)
2-Naftylamine (Dutch)
2-Naphthalamine
2-Naphthalenamine
2-Naphthylamin (German)
2-Naphthylamine mustard
6-Naphthylamine
beta-Naftalamin (Czech)
beta-Naftilamina (Italian)
beta-Naftylamin (Czech)
beta-Naftyloamina (Polish)
beta-Naphthylamin (German)
beta-Naphthylamine
beta-Naphthylamine (ACGIH:OSHA)
C.I. 37270
Fast Scarlet Base B
RCRA waste number U168
USAF CB-22

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assaySalmonella typhimurium/rat250 µmol/kgTXCYAC 16,113,1980
Cytogenetic Analysisintraperitoneal/rat6 mg/kg/72HNULSAK 23,36,1980
Cytogenetic Analysisliver/rat50 mg/LPMRSDJ 1,570,1981
Cytogenetic Analysismultiple/non-mammalian species2500 µg/LMUREAV 319,223,1993
Cytogenetic Analysisovary/hamster3330 µg/LPMRSDJ 1,551,1981
DNA adductAscites tumor/mouse30 µmol/LMUREAV 89,95,1981
DNA adductoral/Dog60 µmol/kgEVHPAZ 49,125,1983
DNA adductoral/Dog8 mg/kgCRNGDP 2,467,1981
DNA adduct/Escherichia coli30 µmol/LMUREAV 89,95,1981
DNA Damage/Bacillus subtilis2 mg/discPMRSDJ 1,175,1981
DNA Damage/Other microorganisms1 mmol/LMUREAV 368,235,1996
DNA Damagefibroblast/human50 µmol/LMUREAV 127,107,1984
DNA Damageintraperitoneal/rat1390 µmol/kgCRNGDP 2,1317,1981
DNA Damageliver/rat300 µmol/LMUREAV 113,357,1983
DNA Damagelymphocyte/mammal (species unspecified)1 mmol/LMUREAV 368,235,1996
DNA Damageother cell types/rat0.25 mmol/L/20HTXCYAC 179,115,2002
DNA Damageother cell types/human0.5 mmol/L/20HTXCYAC 179,115,2002
DNA Damageoral/mouse400 mg/kgMUREAV 440,1,1999
DNA inhibitionintraperitoneal/mouse20 gm/kgARGEAR 51,605,1981
DNA inhibitionHeLa cell/human200 µmol/LMUREAV 92,427,1982
DNA inhibitionHeLa cell/human20 mmol/LMUREAV 93,447,1982
DNA inhibitionliver/rat10 µmol/LCNREA8 45,337,1985
DNA repair/Saccharomyes cerevisiae50 mg/LPMRSDJ 1,502,1981
DNA repair/Bacillus subtilis5 gm/LMUREAV 42,19,1977
DNA repair/Escherichia coli25 mg/LJJIND8 62,873,1979
gene conversion and mitotic recombination/Saccharomyes cerevisiae50 ppmPMRSDJ 1,481,1981
host-mediated assayEscherichia coli/mouse200 mg/kgMUREAV 272,161,1992
micronucleus testother cell types/mouse229.16 mg/L/4H (+enzymatic activation step)MUTAEX 14,403,1999
micronucleus testmultiple/non-mammalian species2500 µg/LMUREAV 283,157,1992
micronucleus testintraperitoneal/mouse100 mg/kgPMRSDJ 1,698,1981
micronucleus testoral/mouse300 mg/kg/3D-continuousMUREAV 234,161,1990
morphological transformembryo/mouse1 mg/LJNCIAM 52,1167,1974
morphological transformmammary gland/mouse1 µg/LCNREA8 39,1784,1979
morphological transformoral/rat400 mg/kgCNREA8 40,1157,1980
morphological transformembryo/rat5 mg/LJNCIAM 51,799,1973
morphological transformother cell types/human68 mg/LITCSAF 17,719,1981
morphological transformembryo/mouse5 mg/L/72HMUREAV 702,100,2010
morphological transformfibroblast/mouse3 mg/L/10DMUREAV 702,100,2010
morphological transformembryo/hamster45 mg/L/7DMUREAV 755,108,2013
morphological transformembryo/hamster1600 µg/LCRNGDP 1,323,1980
morphological transformkidney/hamster25 mg/LPMRSDJ 1,638,1981
mutation in mammalian somatic cellslymphocyte/mouse225 mg/LPMRSDJ 1,580,1981
mutation in mammalian somatic cellsovary/hamster50 mg/LMUREAV 94,449,1982
mutation in microorganisms/Salmonella typhimurium20 µg/plate/20M (+enzymatic activation step)MUREAV 498,19,2001
mutation in microorganisms/Salmonella typhimurium1 nmol/plate/20MEMMUEG 38,268,2001
mutation in microorganisms/Salmonella typhimurium4 mg/L/72H (+enzymatic activation step)MUREAV 558,181,2004
mutation in microorganisms/Neurospora crassa200 µmol/L (-enzymatic activation step)CNREA8 32,1890,1972
mutation in microorganisms/Saccharomyes cerevisiae698 µmol/L (-enzymatic activation step)MGGEAE 174,39,1979
mutation in microorganisms/Saccharomyes cerevisiae89 mg/L (+enzymatic activation step)PMRSDJ 1,414,1981
mutation in microorganisms/Escherichia coli1 µg/plate (+enzymatic activation step)PMRSDJ 1,387,1981
mutation in microorganisms/Salmonella typhimurium2500 ng/plate (+enzymatic activation step)PMRSDJ 1,261,1981
mutation in microorganisms/Salmonella typhimurium2 µg/plate (-enzymatic activation step)BECTA6 17,739,1977
mutation in microorganisms/Bacillus subtilis5 gm/L (+enzymatic activation step)MUREAV 42,19,1977
mutation in microorganismslymphocyte/mouse4720 µg/L (+enzymatic activation step)EMMUEG 12(Suppl 13),37,1988
other mutation test systems/Escherichia coli7 nmol/tubeMUREAV 147,79,1985
phage inhibition capacity/Escherichia coli25 mg/LCNREA8 41,532,1981
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae50 mg/LPMRSDJ 1,468,1981
sister chromatid exchangeintraperitoneal/mouse100 mg/kgMUREAV 108,225,1983
sister chromatid exchangeovary/hamster5 mg/LPMRSDJ 1,551,1981
specific locus testoral/Drosophila melanogaster700 µmol/LCNREA8 30,195,1970
specific locus testintraperitoneal/mouse100 mg/kgMUREAV 121,267,1983
Unscheduled DNA Synthesisliver/rat10 µmol/LENMUDM 3,11,1981
Unscheduled DNA Synthesisfibroblast/human800 µg/LTXCYAC 21,151,1981
Unscheduled DNA Synthesisliver/hamster50 µmol/LMUREAV 136,255,1984

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/mouse lowest published toxic dose: 100 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
BJCAAI 10,539,1956
intraperitoneal/mouse lowest published toxic dose: 1500 mg/kg/8W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JJIND8 67,1299,1981
intraperitoneal/rat lowest published toxic dose: 1300 mg/kg/13W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application
CNREA8 28,535,1968
multiple/Dog lowest published toxic dose: 3077 mg/kg/78W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
AJPAA4 13,656,1937
multiple/Dog toxic dose: 4379 mg/kg/80W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
JIHTAB 20,46,1938
multiple/Dog toxic dose: 5169 mg/kg/91W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
JIHTAB 20,46,1938
oral/Dog toxic dose: 94500 mg/kg/9Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
BJCAAI 44,892,1981
oral/Dog lowest published toxic dose: 33600 mg/kg/168W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
VOONC* 37,60,1991
oral/Dog toxic dose: 108 mg/kg/4YTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
LANCAO 2,286,1951
oral/Dog lowest published toxic dose: 18 gm/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
JNCIAM 49,193,1972
oral/hamster lowest published toxic dose: 217 mg/kg/45W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
85DAAC 5,129,1966
oral/hamster toxic dose: 365 gm/kg/43W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
IMSUAI 35,564,1966
oral/monkey lowest published toxic dose: 17 gm/kg/5Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
JNCIAM 42,825,1969
oral/mouse toxic dose: 31 gm/kg/2YTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
LANCAO 2,286,1951
oral/mouse lowest published toxic dose: 600 mg/kg/8W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
TXAPA9 82,19,1986
oral/rabbit toxic dose: 30 gm/kg/5YTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
LANCAO 2,286,1951
oral/rabbit lowest published toxic dose: 40 gm/kg/5YTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
LANCAO 2,286,1951
oral/rat lowest published toxic dose: 17100 mg/kg/57W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
BJCAAI 46,646,1982
oral/rat toxic dose: 16 gm/kg/52W- intermittentTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Skin and Appendages: Tumors
CNREA8 37,2943,1977
oral/rat toxic dose: 13 gm/kg/1Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Testicular tumors
JNCIAM 41,985,1968
parenteral/mouse lowest published toxic dose: 18 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease
BECCAN 40,42,1962
subcutaneous/mouse lowest published toxic dose: 1600 mg/kg/40W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
VOONAW 15(2),71,1969
subcutaneous/mouse toxic dose: 80 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
ZEKBAI 58,56,1951
subcutaneous/rat lowest published toxic dose: 6 gm/kg/60W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application
VOONAW 20(8),69,1974
unreported route/Dog lowest published toxic dose: 40 gm/kg/81WTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
VOONAW 15(2),71,1969

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kgNTIS** AD277-689
oral/rat lethal dose (50 percent kill): 727 mg/kg85JCAE -,466,1986
unreported route/Dog lowest published lethal dose: 500 mg/kgLung, Thorax, or Respiration: Cyanosis

Kidney, Ureter, and Bladder: Hematuria

Blood: Methemoglobinemia- Carboxhemoglobinemia
XPHBAO 271,176,1941

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Control as low as possibleDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 4,97,1974
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 4,97,1974
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 99,396,2010
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 100F,90,2012
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 99,396,2010
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 100F,90,2012
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMSUDL 7,261,1987
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 100F,90,2012
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 99,396,2010
TOXICOLOGY REVIEWKHZHAZ 12(2),85,1976
TOXICOLOGY REVIEWADCSAJ 13,271,1970
TOXICOLOGY REVIEWBLFSBY 24,253,1983
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWENTOX* -,104,2005
TOXICOLOGY REVIEWMUREAV 627,59,2007
TOXICOLOGY REVIEWMUREAV 626,135,2007
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWHUTOX* -,649,1996
TOXICOLOGY REVIEWMUREAV 733,39,2012
TOXICOLOGY REVIEWMUREAV 752,99,2013
TOXICOLOGY REVIEWMUREAV 762,37,2014
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWFCTOD7 94,93,2016

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIACarcinogen, JUL2008
Occupational Exposure Limit-FRANCEVME 0.001 ppm (0.005 mg/m3), C1 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYceiling concentration 0.005 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-JAPAN1 carc, MAY2012
Occupational Exposure Limit-NEW ZEALANDcarcinogen, JAN2002
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0 mg/m3, MAC(short term exposure limit) 0 mg/m3, JAN1999
Occupational Exposure Limit-SWEDENGroup A Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDcarc 1, JAN2011
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)see Code of Federal Regulations (CFR) 29,1926.1109CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA)-cancer suspect agentCFRGBR 29,1910.1009,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO beta-NAPHTHYLAMINE-airCarcinogen use 29 Code of Federal Regulations (CFR) 1910.1009NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 50065; Number of Industries 1; Total Number of Facilities 10; Number of Occupations 1; Total Number of Employees Exposed 275; Total Number of Female Employees Exposed 265
National Occupational Hazard Survey 1974Hazard Code 50065; Number of Industries 1; Total Number of Facilities 10; Number of Occupations 5; Total Number of Employees Exposed 420

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-mouse embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA GENETOX PROGRAM 1988, Positive: E coli polA with S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus; N crassa-forward mutation
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Naphthylamines, 5518
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
On EPA IRIS database
OSHA ANALYTICAL METHOD #93
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