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Registry of Toxic Effects of Chemical Substances (RTECS)

Malononitrile, o-chlorobenzylidene-

RTECS #

OO3675000

CAS #

2698-41-1

Updated

December 2014

Molecular Weight

188.62

Molecular Formula

C10H5ClN2

Synonyms

(o-Chlorobenzal)malononitrile
2-Chlorobenzalmalononitrile
2-Chlorobenzylidene malononitrile
2-Chlorobmn
beta,beta-Dicyano-o-chlorostyrene
CS
NCI-C55118
o-Chlorobenzalmalononitrile
o-Chlorobenzylidene malonitrile
o-Chlorobenzylidene malononitrile
o-Chlorobenzylidene malononitrile (ACGIH:OSHA)
Propanedinitrile, ((2-chlorophenyl)methylene)
TL 238
USAF KF-11

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /guinea pig 429 ngAPTOA6 35,412,1974
eye /man 0.005 ppm/20S severeMMEDA9 134,219,1969
eye /man 624 ngAPTOA6 35,412,1974
eye /rabbit 5 mgTXAPA9 4,656,1962
eye /rabbit 1 mg mildTXAPA9 17,295,1970
eye /rabbit 1150 ngAPTOA6 35,412,1974
skin /guinea pig 12%/6H open irritation test mildARTODN 40,75,1978
skin /human 10 mg/1H mildBJDEAZ 90,657,1974
skin /rabbit 12%/6H open irritation test mildARTODN 40,75,1978
skin /rat 12%/6H open irritation test mildARTODN 40,75,1978

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster6 mg/LNTPTR* NTP-TR-377,1990
Cytogenetic Analysislung/hamster9400 nmol/LMUREAV 282,231,1992
micronucleus testlung/hamster19 µmol/LARTODN 63,314,1989
mutation in mammalian somatic cellslymphocyte/mouse2500 µg/LEMMUEG 11,91,1988
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+/-enzymatic activation step)ARTODN 49,15,1981
sister chromatid exchangeovary/hamster10 mg/LNTPTR* NTP-TR-377,1990
sister chromatid exchangelung/hamster18800 nmol/LMUREAV 282,231,1992

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 6 mg/m3/5M (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)37QLAZ -,79,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog Lowest published lethal concentration: 2600 mg/m3/23MLung, Thorax, or Respiration: Other changesFEPRA7 30(1),86,1971
inhalation/guinea pig Lowest published lethal concentration: 2326 mg/m3/10MOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
ARTODN 40,75,1978
inhalation/human lowest published toxic concentration: 1500 µg/m3/90MEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes
AEHLAU 6,366,1963
inhalation/mouse Lowest published lethal concentration: 2753 mg/m3/20MOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
ARTODN 40,75,1978
inhalation/rabbit Lowest published lethal concentration: 1802 mg/m3/10MOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
ARTODN 40,75,1978
inhalation/rat Lowest published lethal concentration: 1806 mg/m3/45MOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
ARTODN 40,75,1978
intraperitoneal/guinea pig lethal dose (50 percent kill): 73 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Other changes

Skin and Appendages: Other: Hair
ARTODN 40,75,1978
intraperitoneal/mouse lethal dose (50 percent kill): 32320 µg/kgImmunological Including Allergic: Decrease in humoral immune responseTOLED5 8,73,1981
intraperitoneal/rabbit lethal dose (50 percent kill): 32065 µg/kgBlood: Other changesTOXID9 3,64,1983
intraperitoneal/rat lethal dose (50 percent kill): 48 mg/kgTXAPA9 24,45,1973
intravenous/mouse lethal dose (50 percent kill): 48 mg/kgENTOX* ,706,2005
intravenous/mouse lethal dose (50 percent kill): 47700 µg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
TXAPA9 25,111,1973
intravenous/rabbit lethal dose (50 percent kill): 8 mg/kgEye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 4,656,1962
intravenous/rat lethal dose (50 percent kill): 28 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Other changes
ARTODN 40,75,1978
oral/guinea pig lethal dose (50 percent kill): 212 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Other changes

Skin and Appendages: Other: Hair
ARTODN 40,75,1978
oral/mouse lethal dose (50 percent kill): 282 mg/kgNTIS** AD837-111
oral/rabbit lethal dose (50 percent kill): 143 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Other changes

Skin and Appendages: Other: Hair
ARTODN 40,75,1978
oral/rat lethal dose (50 percent kill): 178 mg/kgGastrointestinal: GastritisAEHLAU 24,449,1972
subcutaneous/mouse Lethal dose: >800 mg/kgTXAPA9 4,656,1962

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 10 mg/m3/6H/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-377,1990
inhalation/mouse lowest published toxic concentration: 3 mg/m3/6H/13W- intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-377,1990
inhalation/rat lowest published toxic concentration: 100 mg/m3/6H/14D- intermittentEye: Lacrimation

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-377,1990
inhalation/rat lowest published toxic concentration: 1500 µg/m3/6H/13W- intermittentOlfaction: Other olfaction effects

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-377,1990
intraperitoneal/mouse lowest published toxic dose: 160 mg/kg/10D- intermittentLiver: Changes in liver weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response
BECTA6 26,571,1981

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 0.05 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCPEMM* 3,239,2002
TOXICOLOGY REVIEWENTOX* -,686,2005
TOXICOLOGY REVIEWENTOX* -,706,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWHTCWA* 2,153,
TOXICOLOGY REVIEWCCACL* 21,719,2005
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWTOLED5 204,148,2011

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.05 ppm (0.4 mg/m3)DTLVS* 3,50,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAceiling concentration 0.05 ppm (0.39 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.05 ppm (0.4 mg/m3);KZW 0.05 ppm (0.4 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.05 ppm (0.4 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 0.05 ppm (0.4 mg/m3), skin, MAY2011
Occupational Exposure Limit-FRANCEshort term exposure limit 0.05 ppm (0.4 mg/m3), Skin, FEB2006
Occupational Exposure Limit-ICELANDshort term exposure limit 0.05 ppm (0.4 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAceiling concentration 0.05 ppm (0.4 mg/m3), 2006
Occupational Exposure Limit-MEXICOpeak 0.5 ppm (0.4 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDceiling concentration 0.05 ppm (0.39 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.05 ppm (0.4 mg/m3), JAN1999
Occupational Exposure Limit-PERUshort term exposure limit 0.05 ppm (0.39 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 ppm (0.4 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-C 0.4 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 05 ppm (0.4 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.05 ppm (0.4 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.05 ppm (0.4 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.05 ppm (0.4 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.05 ppm (0.4 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-CHLOROBENZYLIDENEMALONONITRILE-airceiling concentration 0.05 ppm (Sk)NIOSH* DHHS #95-121,1995

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat
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