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Registry of Toxic Effects of Chemical Substances (RTECS)

Diethylamine

RTECS #

HZ8750000

CAS #

109-89-7

Updated

September 2013

Molecular Weight

73.16

Molecular Formula

C4H11N

Synonyms

DEN
Diaethylamin (German)
Diethamine
Diethylamine (ACGIH:OSHA)
Dietilamina (Italian)
Dwuetyloamina (Polish)
Ethanamine, N-ethyl-
N,N-Diethylamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg open irritation test mildUCDS** 5/21/1971

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Other microorganisms50 µL/plate (-enzymatic activation step)EJMBA2 16,133,1981
mutation in microorganisms/Other microorganisms400 µL/plate (-enzymatic activation step)EJMBA2 15,113,1980
mutation in microorganisms/Other microorganisms200 µL/plate (-enzymatic activation step)EJMBA2 15,113,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 7.9 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 5000 mg/m3TPKVAL 14,80,1975
inhalation/mouse lowest published toxic concentration: 0.25 gm/m3Behavioral: Alteration of classical conditioningTPKVAL 7,56,1965
inhalation/mouse lethal concentration (50 percent kill): 5 gm/m3TPKVAL 7,56,1965
inhalation/mouse Lowest published lethal concentration: 3 gm/m3Eye: Conjunctiva irritationTPKVAL 7,56,1965
inhalation/mouse Lowest published lethal concentration: 3 gm/m3/2HBrain and Coverings: Recordings from specific areas of CNS

Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Fatty liver degeneration
GISAAA 20(4),28,1955
inhalation/rabbit Lowest published lethal concentration: 20 gm/m3Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Emphysema

Liver: Fatty liver degeneration
12OVAW -,176,1960
inhalation/rat lethal concentration (50 percent kill): 4000 ppm/4HENTOX* -,34,2005
inhalation/rat lowest published toxic concentration: 0.3 gm/m3TPKVAL 7,56,1965
intraperitoneal/mouse lethal dose (50 percent kill): 585 mg/kgYKKZAJ 97,1117,1977
intraperitoneal/rat lowest published lethal dose: 50 mg/kgFATOAO 31,238,1968
oral/mouse lethal dose (50 percent kill): 500 mg/kgBehavioral: Sleep

Behavioral: Somnolence (general depressed activity)
BBIADT 44,795,1985
oral/rat lethal dose (50 percent kill): 540 mg/kgENTOX* -,34,2005
skin/rabbit lethal dose (50 percent kill): 820 µL/kgAMIHBC 4,119,1951
skin/rabbit lethal dose (50 percent kill): 580 mg/kgENTOX* -,34,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 250 ppm/6H/24W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 6,559,1986
inhalation/rat lowest published toxic concentration: 4 mg/m3/24H/93D- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 33(1),28,1968
oral/rat lowest published toxic dose: 4994 mg/kg/11W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainGISAAA 30(9),28,1965

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 ppm;short term exposure limit 15 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCHREAY 9,389,1931
TOXICOLOGY REVIEWENTOX* -,34,2005

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 25 ppm (75 mg/m3)DTLVS* 3,84,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 ppm (30 mg/m3), short term exposure limit 25 ppm (75 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (15 mg/m3);KZW 5 ppm (15 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (15 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 10 ppm (30 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (15 mg/m3), skin, MAY2011
Occupational Exposure Limit-ECtime-weighted average 15 mg/m3 (5 ppm);short term exposure limit 30 mg/m3 (10 ppm), FEB2006
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (15 mg/m3), short term exposure limit 10 ppm (30 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVLE 10 ppm (30 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 5 ppm (15 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 30 mg/m3, short term exposure limit 30 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (15 mg/m3), short term exposure limit 10 ppm (30 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 10 ppm (30 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (30 mg/m3), short term exposure limit 25 ppm (75 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 ppm (30 mg/m3);short term exposure limit 25 ppm (75 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 ppm (30 mg/m3); short term exposure limit 25 ppm (75 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 10 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 ppm (15 mg/m3); short term exposure limit 15 ppm (45 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 30 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (30 mg/m3);short term exposure limit 15 ppm (45 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (15 mg/m3), KZG-week 10 ppm (30 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 15 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 25 ppm (75 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 25 ppm (75 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 ppm (15 mg/m3);short term exposure limit 10 ppm (30 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 25 ppm (75 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 25 ppm (75 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 25 ppm (75 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 25 ppm (75 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIETHYLAMINE-air10H time-weighted average 10 ppm;short term exposure limit 25 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 24680; Number of Industries 22; Total Number of Facilities 1387; Number of Occupations 24; Total Number of Employees Exposed 28361; Total Number of Female Employees Exposed 6878
National Occupational Hazard Survey 1974Hazard Code 24680; Number of Industries 20; Total Number of Facilities 2138; Number of Occupations 28; Total Number of Employees Exposed 34647

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Amines, aliphatic, 2010
NTP Carcinogenesis studies; selected, October 2000
OSHA ANALYTICAL METHOD #41
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