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Registry of Toxic Effects of Chemical Substances (RTECS)

Carbamic acid, methyl-, 1-naphthyl ester

RTECS #

FC5950000

CAS #

63-25-2; 11095-11-7; 52001-89-5

Updated

October 2017

Molecular Weight

201.24

Molecular Formula

C12H11NO2

Synonyms

1-Naftylester kyseliny methylkarbaminove (Czech)
1-Naphthalenol, methylcarbamate (9CI)
1-Naphthalenyl methylcarbamate
1-Naphthol N-methylcarbamate
1-Naphthyl methylcarbamate
1-Naphthyl N-methylcarbamate
1-Naphthyl-N-methyl-karbamat (German)
alpha-Naftyl-N-methylkarbamat (Czech)
alpha-Naphthalenyl methylcarbamate
alpha-Naphthyl N-methylcarbamate
Arilat
Arilate
Arylam
Atoxan
Bug master
Carbaril
Carbaryl
Carbaryl (ACGIH:OSHA)
Carbatox
Carbatox-60
Carbatox-75
Carbavur
Carbomate
Carylderm
Cekubaryl
Compound 7744
Crunch
Denapon
Dicarbam
Dyna-carbyl
ENT 23,969
Experimental Insecticide 7744
Germain's
Hexavin
Karbaryl (Polish)
Karbatox
Karbatox 75
Karbatox zawiesinowy
Karbosep
Latka 7744 (Czech)
Menaphtam
Methylcarbamic acid, 1-naphthyl ester
Monsur
Mugan
Murvin
NAC (insecticide)
NMC 50
N-Methyl-1-naftyl-carbamaat (Dutch)
N-Methyl-1-naphthyl carbamate
N-Methyl-1-naphthyl-carbamat (German)
N-Methyl-alpha-naphthylcarbamate
N-Methyl-alpha-naphthylurethan
N-Methylcarbamate de 1-naphtyle (French)
N-Metil-1-naftil-carbammato (Italian)
Oltitox
OMS-29
Panam
Pomex
Prosevor 85
Ravyon
Savit
Seffein
Sevimol
Sevin
Sevin (OSHA)
Sevin 4
Tercyl
Toxan
Tricarnam
UC 7744
Union carbide 7,744
Vetox
Vioxan

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,955,1986
skin /rabbit 12 mg/24H severeJAFCAU 9,30,1961

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisparenteral/grasshopper100 pphCUSCAM 43,187,1974
Cytogenetic Analysisembryo/human40 mg/LZDVKAP 20(4),14,1977
Cytogenetic Analysisfibroblast/hamster30 mg/L/48HMUREAV 48,337,1977
Cytogenetic Analysislung/hamster100 µmol/LMUREAV 119,319,1983
DNA inhibitionother cell types/rat1 mg/LARTODN 45,101,1980
DNA inhibitionAscites tumor/mouse100 µmol/LBECTA6 14,441,1975
DNA inhibitionlymphocyte/human50 mg/LARTODN 45,101,1980
DNA inhibitionlung/human1 mmol/LNNGADV 8,353,1983
host-mediated assayAscites tumor/mouse60 mg/kg/5D- intermittentBECTA6 14,441,1975
micronucleus testmultiple/non-mammalian species5 ppm/8D-continuousMUREAV 125,275,1984
mutation in mammalian somatic cellslung/hamster10 µmol/LCBINA8 19,369,1977
mutation in microorganisms/Saccharomyes cerevisiae100 ppm (-enzymatic activation step)RSTUDV 6,161,1976
mutation in microorganisms/Salmonella typhimurium250 µg/plate (+enzymatic activation step)RPZHAW 30,81,1979
mutation in microorganisms/Salmonella typhimurium100 µmol/L (-enzymatic activation step)ARTODN 39,159,1977
mutation in microorganisms/Other microorganisms5 mg/L (-enzymatic activation step)JASIAB 104,571,1985
other mutation test systemslung/human1 mmol/LNNGADV 8,353,1983
other mutation test systemsfibroblast/human100 mg/kgGTPZAB 17(3),32,1973
other mutation test systemsAscites tumor/mouse400 µmol/LBECTA6 14,441,1975
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster1 pph/24HSOGEBZ 8,798,1972
sex chromosome loss and nondisjunctionlung/hamster50 µmol/LMUREAV 119,319,1983
sperm morphologyintraperitoneal/mouse1 mmol/LBSRSA6 45,46,1976
sperm morphologyoral/mouse1 mmol/LBSRSA6 45,46,1976
Unscheduled DNA Synthesisfibroblast/human1 µmol/LMUREAV 42,161,1977

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1370 mg/kg (39W prior to copulation)Reproductive: Maternal effects: Menstrual cycle changes or disordersVPITAR 27(6),49,1968
oral/rat 5500 mg/kg (multigenerations)Reproductive: Effects on fertility: Other measures of fertilityTXAPA9 17,273,1970
oral/rat 27500 µg/kg (multigenerations)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TXAPA9 21,390,1972
oral/rat 220 mg/kg (5-15D pregnant)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)TXAPA9 21,390,1972
oral/rat 1370 mg/kg (39W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)VPITAR 27(6),49,1968
oral/rat 5475 mg/kg (52W prior to copulation)Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
VPITAR 27(6),49,1968
oral/rat 3250 mg/kg (13W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)VHTODE 37,421,1995
oral/mouse 11660 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TXAPA9 51,81,1979
oral/mouse 100 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
FCTOD7 29,629,1991
oral/mouse 200 mg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
FCTOD7 29,629,1991
oral/mouse 150 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear
FCTOD7 29,629,1991
oral/Dog 375 mg/kg (3-62D pregnant)Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Hepatobiliary system
TXAPA9 13,392,1968
oral/Dog 750 mg/kg (3-62D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TXAPA9 13,392,1968
oral/Dog 197 mg/kg (1-63D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Stillbirth
32OAAP -,253,1973
oral/Dog 394 mg/kg (1-63D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Gastrointestinal system
32OAAP -,253,1973
oral/rabbit 1950 mg/kg (6-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects on female

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 51,81,1979
oral/rabbit 2600 mg/kg (6-18D pregnant)Reproductive: Specific developmental abnormalities: Body wallTXAPA9 51,81,1979
oral/pig 912 mg/kg (1-16W pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)32OAAP -,253,1973
oral/guinea pig 300 mg/kg (12-16D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTXAPA9 15,152,1969
oral/hamster 250 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathTXAPA9 15,152,1969
oral/gerbil 12500 mg/kg (multigenerations)Reproductive: Effects on fertility: Other measures of fertilityTXAPA9 17,273,1970
oral/gerbil 20300 mg/kg (multigenerations)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TXAPA9 19,202,1971
oral/gerbil 20300 mg/kg (multigenerations)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)TXAPA9 19,202,1971
oral/gerbil 40600 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TXAPA9 19,202,1971
oral/rat 375 mg/kg (14-22D preg/7D after birth)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)TOXID9 36,344,1997
oral/rat 555 mg/kg (7-22D preg/21D after birth)Reproductive: Effects on newborn: Biochemical and metabolicFCTOD7 99,135,2017
subcutaneous/mouse 900 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** PB223-160
subcutaneous/mouse 900 mg/kg (6-14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NTIS** PB223-160
subcutaneous/mouse 418 mg/kg (6-14D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)NTIS** PB223-160
subcutaneous/mouse 4176 mg/kg (6-14D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathNTIS** PB223-160

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rat lowest published toxic dose: 80 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
VPITAR 29,71,1970
oral/rat lowest published toxic dose: 5640 mg/kg/94W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors
VPITAR 29,71,1970

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Rat, endocrine tumor Inhibitor Concentration (50 percent kill): >10 µmol/L/20MIn Vitro Toxicity Studies: Other assaysNRTXDN 43,110,2014
In Vitro/Rat, neurons Inhibitor Concentration Low: 40 µmol/L/1HIn Vitro Toxicity Studies: Other assaysNRTXDN 44,204,2014
In Vitro/Rat, neurons Inhibitor Concentration (50 percent kill): 5.03 µmol/L/10MIn Vitro Toxicity Studies: Other assaysNRTXDN 40,75,2014
In Vitro/Rat, neurons Inhibitor Concentration Low: 25 mg/L/2HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTIVIEQ 3,111,1989
In Vitro/Rat, neurons Inhibitor Concentration (50 percent kill): 17 mmol/L/2HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTIVIEQ 3,111,1989
inhalation/cat lowest published toxic concentration: 40 mg/m3Behavioral: Change in motor activity (specific assay)HBPTO* 2,1099,2001
inhalation/guinea pig Lethal concentration: >390 mg/m3/4HUCDS** 11/21/1973
inhalation/rat lowest published toxic concentration: 300 mg/m3/15MBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTOXID9 -,175,2009
inhalation/rat lowest published toxic concentration: 30 mg/m3/3HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTOXID9 -,175,2009
inhalation/rat lethal concentration (50 percent kill): 5 mg/m3HBPTO* 2,1094,2001
intramuscular/monkey lowest published toxic dose: 3 mg/kgPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Peripheral Nerve and Sensation: Structural change in nerve or sheath
HBPTO* 2,1100,2001
intramuscular/rat lowest published toxic dose: 3 mg/kgBehavioral: Alteration of operant conditioningHBPTO* 2,1095,2001
intraperitoneal/hamster lethal dose (50 percent kill): 640 mg/kgARTODN 58,152,1986
intraperitoneal/mouse lethal dose (50 percent kill): 25 mg/kgTXAPA9 6,402,1964
intraperitoneal/rabbit lethal dose (50 percent kill): 223 mg/kgJAFCAU 9,30,1961
intraperitoneal/rat lethal dose (50 percent kill): 64 mg/kgPSEBAA 114,509,1963
intraperitoneal/rat lowest published toxic dose: 7.3 mg/kgBehavioral: Change in psychophysiological testsHBPTO* 2,1099,2001
intravenous/rat lethal dose (50 percent kill): 18 mg/kgJAFCAU 9,30,1961
oral/cat lethal dose (50 percent kill): 150 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Gastrointestinal: Changes in structure or function of salivary glands
GISAAA 32(4),29,1967
oral/cat lethal dose (50 percent kill): 125 mg/kgHBPTO* 2,1094,2001
oral/Dog lethal dose (50 percent kill): 250 mg/kgHBPTO* 2,1094,2001
oral/gerbil lethal dose (50 percent kill): 491 mg/kgPCBPBS 21,199,1984
oral/guinea pig lethal dose (50 percent kill): 250 mg/kgPCBPBS 21,199,1984
oral/hamster lowest published lethal dose: 250 mg/kgTXAPA9 15,152,1969
oral/human lowest published toxic dose: 2.8 mg/kgGastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes
HBPTO* 2,1096,2001
oral/mammal (species unspecified) lethal dose (50 percent kill): 510 mg/kgHPBIA9 21,53,1975
oral/man lowest published toxic dose: 500 mg/kgPeripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Muscle weakness
NEURAI 37,1229,1987
oral/monkey lethal dose (50 percent kill): 1000 mg/kgHBPTO* 2,1094,2001
oral/mouse lethal dose (50 percent kill): 108 mg/kgHBPTO* 2,1094,2001
oral/pig lethal dose (50 percent kill): 1500 mg/kgHBPTO* 2,1094,2001
oral/pig lowest published toxic dose: 20 mg/kgBehavioral: Change in psychophysiological testsHBPTO* 2,1098,2001
oral/quail lethal dose (50 percent kill): 829 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands
OYYAA2 51,137,1996
oral/rabbit lethal dose (50 percent kill): 710 mg/kgHBPTO* 2,1094,2001
oral/rat lethal dose (50 percent kill): 233 mg/kgHBPTO* 2,1094,2001
oral/rat lowest published toxic dose: 0.56 mg/kgBehavioral: Change in psychophysiological testsHBPTO* 2,1100,2001
oral/rat lethal dose (50 percent kill): 230 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 11,546,1967
oral/rat lowest published lethal dose: 75 mg/kgBehavioral: Tremor

Nutritional and Gross Metabolic: Body temperature decrease

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXCYAC 217,1,2006
oral/rat lowest published toxic dose: 3 mg/kgBehavioral: Change in motor activity (specific assay)TOXID9 90,302,2006
oral/rat lowest published toxic dose: 3 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NRTXDN 29,87,2008
oral/rat lowest published toxic dose: 50 mg/kgBehavioral: Tremor

Behavioral: Alteration of classical conditioning

Gastrointestinal: Changes in structure or function of salivary glands
TOXID9 44,224,2005
oral/rat lowest published toxic dose: 15 mg/kgBehavioral: Change in motor activity (specific assay)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 66,321,2002
oral/rat lowest published toxic dose: 10 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterasesTXCYAC 217,1,2006
oral/rat lowest published toxic dose: 50 mg/kgBehavioral: Tremor

Nutritional and Gross Metabolic: Body temperature decrease

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXCYAC 217,1,2006
oral/rat lowest published toxic dose: 10 mg/kgCardiac: EKG changes not diagnostic of above

Nutritional and Gross Metabolic: Body temperature decrease

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 282,184,2015
oral/rat lowest published toxic dose: 50 mg/kgEndocrine: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 282,161,2015
oral/rat lowest published toxic dose: 3 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXCYAC 331,1,2015
oral/rat lowest published toxic dose: 75 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)TOXID9 -,337,2009
oral/rat lowest published toxic dose: 50 mg/kgBrain and Coverings: Changes in surface EEG

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 -,441,2009
oral/rat lowest published toxic dose: 75 mg/kgBrain and Coverings: Recordings from specific areas of CNSNRTXDN 29,87,2008
oral/rat lowest published toxic dose: 30 mg/kgNutritional and Gross Metabolic: Body temperature decreaseNRTXDN 29,87,2008
oral/rat lowest published toxic dose: 30 mg/kgPeripheral Nerve and Sensation: Fasciculations

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor
TOXID9 12,478,2008
oral/rat lowest published toxic dose: 75 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Body temperature decrease

Biochemical: Metabolism (intermediary): Other
NRTXDN 30,377,2009
oral/wild bird lethal dose (50 percent kill): 56 mg/kgTXAPA9 21,315,1972
oral/woman lowest published lethal dose: 5 gm/kgAutonomic Nervous System: Parasympatholytic

Cardiac: Change in rate

Nutritional and Gross Metabolic: Other changes
HETOEA 11,373,1992
skin/rabbit lethal dose (50 percent kill): 2 gm/kg85DPAN -,-,1971/1976
skin/rat lethal dose (50 percent kill): 4 gm/kg85DPAN -,-,1971/1976
subcutaneous/chicken lowest published lethal dose: 2 gm/kgJAFCAU 9,30,1961
subcutaneous/mouse lethal dose (50 percent kill): 860 mg/kgAHRTAN 29,251,1978
subcutaneous/rabbit Lethal dose: >2 gm/kgJAFCAU 9,30,1961
subcutaneous/rat lethal dose (50 percent kill): 1400 mg/kg34ZIAG -,528,1969
Tank with water/Lugworm lethal concentration (50 percent kill): 7.2 mg/L/48HAQUTO* 10,235,1987
Tank with water/Shrimp lethal concentration (50 percent kill): 12 µg/L/96HEESADV 73,360,2010
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 310 mg/kgGISAAA 53(7),72,1988
unreported route/mouse lethal dose (50 percent kill): 370 mg/kgGISAAA 49(10),23,1984
unreported route/rat lethal dose (50 percent kill): 500 mg/kg30ZDA9 -,188,1971
unreported route/rat lowest published toxic dose: 80 mg/kgBehavioral: Change in motor activity (specific assay)TOXID9 72,128,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 63 mg/kg/4W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GISAAA 32(4),29,1967
inhalation/rat lowest published toxic concentration: 214 µg/m3/24H/13W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 53(7),72,1988
inhalation/rat lowest published toxic concentration: 12 mg/m3/6H/16W- intermittentBehavioral: Change in psychophysiological testsHBPTO* 2,1100,2001
inhalation/rat lowest published toxic concentration: 23 mg/m3/4H/17W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning
GISAAA 43(11),33,1978
oral/mouse lowest published toxic dose: 11.4 gm/kg/16D- continuousBehavioral: Food intake (animal)FCTOD7 41,99,2003
oral/mouse lowest published toxic dose: 15.2 gm/kg/20D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainFCTOD7 41,99,2003
oral/mouse lowest published toxic dose: 32.22 gm/kg/180D- continuousLiver: Changes in liver weight

Endocrine: Changes in thymus weight
FCTOD7 41,99,2003
oral/mouse lowest published toxic dose: 3222 mg/kg/180D- continuousKidney, Ureter, and Bladder: Other changesFCTOD7 41,99,2003
oral/mouse lowest published toxic dose: 16.8 gm/kg/7D- intermittentBehavioral: Fluid intake

Behavioral: Change in motor activity (specific assay)

Behavioral: Aggression
BECTA6 71,37,2003
oral/pig lowest published toxic dose: 8157 mg/kg/72D- intermittentBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Musculoskeletal: Other changes
TXAPA9 14,409,1969
oral/pig lowest published toxic dose: 9.6 gm/kg/46D- intermittentPeripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Ataxia

Behavioral: Muscle contraction or spasticity
HBPTO* 2,1098,2001
oral/quail lowest published toxic dose: 13230 mg/kg/14W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BECTA6 17,360,1977
oral/rabbit lowest published toxic dose: 7.59 mg/kg/33D- continuousImmunological Including Allergic: Decrease in humoral immune responseTXAPA9 32,587,1975
oral/rabbit lowest published toxic dose: 131.1 mg/kg/57D- continuousEndocrine: Other changesTXAPA9 32,587,1975
oral/rat lowest published toxic dose: 4725 mg/kg/21D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FCTOD7 47,86,2009
oral/rat lowest published toxic dose: 4725 mg/kg/21D- intermittentLiver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FCTOD7 47,86,2008
oral/rat lowest published toxic dose: 720 mg/kg/10D- intermittentBiochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
GISAAA 49(5),80,1984
oral/rat lowest published toxic dose: 300 mg/kg/50D- continuousBrain and Coverings: Recordings from specific areas of CNS

Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 27,465,1974
oral/rat lowest published toxic dose: 30 mg/kg/30D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
BECTA6 23,438,1979
oral/rat lowest published toxic dose: 1050 mg/kg/21D- intermittentLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
AECTCV 14,459,1985
oral/rat lowest published toxic dose: 10800 mg/kg/96D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAFCAU 9,30,1961
oral/rat lowest published toxic dose: 25480 mg/kg/1Y- intermittentEndocrine: Evidence of thyroid hypofunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
FCTXAV 6,461,1968
oral/rat lowest published toxic dose: 1109 mg/kg/22W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
GISAAA 35(7),97,1970
oral/rat lowest published toxic dose: 500 mg/kg/50D- continuousBehavioral: Change in psychophysiological testsHBPTO* 2,1100,2001
unreported route/quail lowest published toxic dose: 50 µg/kg/5D- intermittentImmunological Including Allergic: Decreased immune responseHBPTO* 1,775,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 12,37,1976
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 12,37,1976
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWCNDQA8 10(3),43,1975
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEW85ALAU -,106,1977
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,588,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWFEREAC 73,29456,2008
TOXICOLOGY REVIEWREPTED 26,1,2008
TOXICOLOGY REVIEWMUREAV 681,3,2009
TOXICOLOGY REVIEWFEREAC 73,64229,2008
TOXICOLOGY REVIEWFEREAC 73,52607,2008
TOXICOLOGY REVIEWREPTED 26,13,2008
TOXICOLOGY REVIEWHETOEA 26,321,2007
TOXICOLOGY REVIEWNTAPM* -,711,1995
TOXICOLOGY REVIEWTOLED5 190,107,2009
TOXICOLOGY REVIEWREPTED 31,392,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWMUREAV 760,1,2014
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWNRTXDN 33,1473,2012
TOXICOLOGY REVIEWTXCYAC 307,123,2013
TOXICOLOGY REVIEWTXCYAC 307,136,2013
TOXICOLOGY REVIEWTOLED5 230,146,2014
TOXICOLOGY REVIEWTXAPA9 268,157,2013
TOXICOLOGY REVIEWMUREAV 802,1,2016
TOXICOLOGY REVIEWFCTOD7 83,300,2015

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,94,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 5 mg/m3DTLVS* 3,37,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 mg/m3, skin, carc, MAY2011
Occupational Exposure Limit-FRANCEVME 5 mg/m3, C3 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 1 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 5 mg/m3, skin, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 5 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 mg/m3;short term exposure limit 10 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 8 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 5 mg/m3, carc 3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 5 mg/m3, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 5 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CARBARYL-air10H time-weighted average 5 mg/m3;min expos during pregnancyNIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code 47800; Number of Industries 5; Total Number of Facilities 2381; Number of Occupations 4; Total Number of Employees Exposed 16544; Total Number of Female Employees Exposed 3228
National Occupational Hazard Survey 1974Hazard Code 47800; Number of Industries 5; Total Number of Facilities 678; Number of Occupations 16; Total Number of Employees Exposed 14120

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-human
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Carbaryl, 5006
On EPA IRIS database
OSHA ANALYTICAL METHOD #63
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