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Registry of Toxic Effects of Chemical Substances (RTECS)

4-Biphenylamine

RTECS #

DU8925000

CAS #

92-67-1

Updated

June 2017

Molecular Weight

169.24

Molecular Formula

C12H11N

Synonyms

(1,1'-Biphenyl)-4-amine
4-Aminobifenyl (Czech)
4-Aminobiphenyl
4-Aminodifenil (Spanish)
4-Aminodiphenyl
4-Aminodiphenyl (ACGIH:OSHA)
4-Bifenylamin (Czech)
Biphenylamine
p-Aminobiphenyl
p-Aminodiphenyl
Paraaminodiphenyl
p-Biphenylamine
p-Phenylaniline
Xenylamin (Czech)
Xenylamine

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assaySalmonella typhimurium/rat250 µmol/kgTXCYAC 16,113,1980
body fluid assaySalmonella typhimurium/Dog10 mg/kgCNREA8 37,1757,1977
Cytogenetic Analysisintraperitoneal/mouse25 mg/kgMUREAV 268,255,1992
Cytogenetic Analysislymphocyte/mouse50 mg/LMUREAV 320,69,1994
Cytogenetic Analysisintraperitoneal/rat10 mg/kg/72HNULSAK 23,36,1980
DNA adduct/Escherichia coli30 µmol/LMUREAV 89,95,1981
DNA adductoral/Dog5 mg/kgCNREA8 48,6336,1988
DNA adductskin/mouse8.5 mg/kg/24HTOXID9 72(Supp 1),336,2003
DNA adductoral/mouse80 mg/kgTOSCF2 73,279,2003
DNA adductunreported route/mouse120 mg/kgCBINA8 146,51,2003
DNA adductoral/rat10 mg/kgTOXID9 90,161,2006
DNA adductskin/mouse10 mg/kgJNCIEQ 95,1227,2003
DNA adductintraperitoneal/mouse558.492 µg/kg/8D- intermittentMOCAE8 42,193,2005
DNA Damageintraperitoneal/mouse1692.4 µg/kg/8D- intermittentMOCAE8 42,193,2005
DNA Damageother cell types/human0.06 mmol/plateEMMUEG 38,1,2001
DNA Damageother cell types/rat0.5 mmol/L/20HTXCYAC 179,115,2002
DNA Damageother cell types/human0.125 mmol/L/20HTXCYAC 179,115,2002
DNA Damageother cell types/human60 µmol/LEMMUEG 38,1,2001
DNA Damagelymphocyte/human500 µmol/L/2HTOSCF2 72,283,2003
DNA Damageliver/human37.5 µmol/L/24HTXCYAC 322,69,2014
DNA Damagelung/hamster300 µmol/L/2HBBRCA9 72,732,1976
DNA Damageliver/rat30 µmol/LSinJF# 26OCT1982
DNA repair/Bacillus subtilis200 µg/discMUREAV 97,1,1982
DNA repair/Escherichia coli250 mg/LJJIND8 62,873,1979
gene conversion and mitotic recombination/Saccharomyes cerevisiae2 pphJJIND8 62,901,1979
host-mediated assaySalmonella typhimurium/rat1 mmol/kgMUREAV 93,317,1982
host-mediated assayEscherichia coli/mouse67 mg/kgMUREAV 272,161,1992
micronucleus testintraperitoneal/mouse28 mg/kg/24H-continuousMUREAV 216,321,1989
micronucleus testoral/mouse50 mg/kg/48H- intermittentMUREAV 389,3,1997
morphological transformembryo/mouse10 mg/LJNCIAM 52,1167,1974
morphological transformoral/rat100 mg/kgCNREA8 40,1157,1980
morphological transformembryo/rat10 mg/LJNCIAM 51,799,1973
morphological transformkidney/hamster80 µg/LBJCAAI 37,873,1978
morphological transformembryo/hamster5 mg/LNCIMAV 58,243,1981
morphological transformfibroblast/mouse0.1 mg/L/21D (-enzymatic activation step)EMMUEG 35,300,2000
mutation in mammalian somatic cellslung/hamster5 mg/LCNREA8 43,5194,1983
mutation in mammalian somatic cellslymphocyte/mouse5 mg/LMUREAV 125,291,1984
mutation in mammalian somatic cellsoral/mouse75 mg/kgMUREAV 400,245,1998
mutation in mammalian somatic cellsfibroblast/human60 mg/LMUREAV 121,71,1983
mutation in microorganisms/Salmonella typhimurium2 µg/plate (-enzymatic activation step)ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms/Escherichia coli900 µg/L (+enzymatic activation step)CNREA8 39,682,1979
mutation in microorganisms/Salmonella typhimurium3 µg/plate (+enzymatic activation step)TOSCF2 56,351,2000
mutation in microorganisms/Salmonella typhimurium10 µg/plate/20M (+enzymatic activation step)MUREAV 515,15,2002
mutation in microorganisms/Salmonella typhimurium1 nmol/plate/20MEMMUEG 38,268,2001
mutation in microorganisms/Salmonella typhimurium600 µmol/L/3HTCMUD8 23,47,2003
mutation in microorganisms/Escherichia coli30 nmol/plate (+enzymatic activation step)MUTAEX 20,199,2005
mutation in microorganisms/Escherichia coli37.5 nmol/plate/48H (+enzymatic activation step)MUTAEX 20,199,2005
other mutation test systemsintraperitoneal/mouse100 mg/kgMUREAV 268,255,1992
other mutation test systemslymphocyte/mouse50 mg/LMUREAV 320,69,1994
phage inhibition capacity/Escherichia coli25 mg/LCNREA8 41,532,1981
sister chromatid exchangeintraperitoneal/hamster50 mg/kgMUREAV 113,33,1983
sister chromatid exchangeoral/hamster50 mg/kgMUREAV 113,33,1983
specific locus testoral/Drosophila melanogaster500 µmol/LMUREAV 242,169,1990
specific locus testintraperitoneal/mouse0.3 µmol/2D- intermittentMUTAEX 21,29,2006
specific locus testovary/hamster5 mg/L/9DEMMUEG 16,260,1990
Unscheduled DNA Synthesisliver/human100 µg/LMUREAV 206,91,1988
Unscheduled DNA Synthesisfibroblast/human800 µg/LTXCYAC 21,151,1981
Unscheduled DNA Synthesisoral/mouse200 mg/kgENMUDM 6,474,1984
Unscheduled DNA Synthesisliver/rabbit500 µmol/LCNREA8 43,3120,1983
Unscheduled DNA Synthesisoral/rat200 mg/kgENMUDM 6,474,1984
Unscheduled DNA Synthesisliver/rat3 µmol/LMUREAV 216,101,1989

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 85 µg/kgTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
CALEDQ 185,13,2002
oral/Dog toxic dose: 5580 mg/kg/4Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
NEOLA4 15,3,1968
oral/Dog toxic dose: 8200 mg/kg/90W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
JAMAAP 172,1611,1960
oral/Dog toxic dose: 8200 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
IMSUAI 27,25,1958
oral/Dog toxic dose: 9600 mg/kg/3Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
IMSUAI 27,25,1958
oral/Dog toxic dose: 8400 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
IMSUAI 27,25,1958
oral/Dog toxic dose: 14 gm/kg/3Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
IMSUAI 27,25,1958
oral/mouse toxic dose: 5460 µg/kgTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Blood: Tumors
EJCODS 21,865,1985
oral/mouse lowest published toxic dose: 1520 mg/kg/39W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
BJCAAI 19,297,1965
oral/rat lowest published toxic dose: 5 gm/kg/52W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
ARZNAD 12,270,1962
subcutaneous/mouse lowest published toxic dose: 216 mg/kg/3D- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
JNCIAM 41,403,1968
subcutaneous/rat toxic dose: 5000 mg/kg/1W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
BMBUAQ 14,141,1958
subcutaneous/rat lowest published toxic dose: 4560 mg/kg/44W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
NATUAS 175,1131,1955

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration Low: 100 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 322,69,2014
intraperitoneal/mouse lowest published lethal dose: 250 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
CBCCT* 6,54,1954
intraperitoneal/rat lowest published toxic dose: 10 µg/kgBlood: Other changesBECTA6 67,649,2001
oral/Dog lowest published lethal dose: 25 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaSCIEAS 167,992,1970
oral/Dog lethal dose (50 percent kill): 25 mg/kgENTOX* -,92,2005
oral/mouse lethal dose (50 percent kill): 205 mg/kgEJCODS 21,865,1985
oral/mouse lowest published toxic dose: 120 mg/kgLiver: Other changesTOXID9 66,10,2002
oral/rabbit lethal dose (50 percent kill): 690 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JIHTAB 29,1,1947
oral/rat lethal dose (50 percent kill): 500 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JIHTAB 29,1,1947
oral/rat lethal dose (50 percent kill): 500 mg/kgENTOX* -,92,2005
oral/rat lowest published toxic dose: 0.1 µg/kgBlood: Other changesBECTA6 67,649,2001
skin/mouse lowest published toxic dose: 16.9 mg/kgLiver: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TXAPA9 181,32,2002

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 16755 µg/kg/8D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainMOCAE8 42,193,2005

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Control as low as possibleDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 1,74,1972
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 1,74,1972
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 28,151,1982
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 99,100,2010
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 100F,50,2012
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 99,100,2010
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 100F,50,2012
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMSUDL 7,91,1987
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 100F,50,2012
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 99,100,2010
TOXICOLOGY REVIEWKHZHAZ 12(2),85,1976
TOXICOLOGY REVIEWADCSAJ 13,271,1970
TOXICOLOGY REVIEWBLFSBY 24,253,1983
TOXICOLOGY REVIEWARPTDI 43,485,2003
TOXICOLOGY REVIEWTOLED5 134,39,2002
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWTXAPA9 197,144,2004
TOXICOLOGY REVIEWMUTAEX 14,301,1999
TOXICOLOGY REVIEWTCMUD8 23(Suppl 1),187,2003
TOXICOLOGY REVIEWMUREAV 588,88,2005
TOXICOLOGY REVIEWMUREAV 612,58,2006
TOXICOLOGY REVIEWMUREAV 567,427,2004
TOXICOLOGY REVIEWMUREAV 567,447,2004
TOXICOLOGY REVIEWENTOX* -,92,2005
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWTOPADD 33,517,2005
TOXICOLOGY REVIEWMUREAV 659,68,2008
TOXICOLOGY REVIEWHUTOX* -,649,1996
TOXICOLOGY REVIEWMUREAV 574,92,2005
TOXICOLOGY REVIEWMUREAV 590,1,2005
TOXICOLOGY REVIEWMUTAEX 23,1,2008
TOXICOLOGY REVIEWMUREAV 579,6,2005
TOXICOLOGY REVIEWMUREAV 705,107,2010
TOXICOLOGY REVIEWMUREAV 751,49,2012
TOXICOLOGY REVIEWMUREAV 752,99,2013
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWMUREAV 767,1,2016
TOXICOLOGY REVIEWMUREAV 768,27,2016
TOXICOLOGY REVIEWMUTAEX 31,117,2016
TOXICOLOGY REVIEWMUREAV 802,1,2016
TOXICOLOGY REVIEWFCTOD7 94,93,2016

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDskin-HUMAN CARCINOGEN, NO ASSIGNED time-weighted averageDTLVS* 3,10,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAProhibited, Carcinogen, JUL2008
Occupational Exposure Limit-BELGIUMSkin, MAR2002
Occupational Exposure Limit-FRANCEVME 0.001 ppm (0.007 mg/m3), C1 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYceiling concentration 10 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-JAPAN1 carc, MAY2012
Occupational Exposure Limit-KOREAcarcinogen, skin, 2006
Occupational Exposure Limit-NEW ZEALANDcarcinogen, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit-SWEDENGroup A Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDcarc 1, JAN2011
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)see Code of Federal Regulations (CFR) 29,1926.1111CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)see Code of Federal Regulations (CFR) 29,1910.1011CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)see Code of Federal Regulations (CFR) 29,1915.1011CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA)-cancer suspect agentCFRGBR 29,1910.1011,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4-AMINODIPHENYL-airCarcinogen use 29 Code of Federal Regulations (CFR) 1910.1011NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: Body fluid assay; Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: E coli polA with S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS in rat liver; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; Cell transform.-mouse embryo
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #93
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