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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, p-dinitro-

RTECS #

CZ7525000

CAS #

100-25-4

Updated

September 2013

Molecular Weight

168.12

Molecular Formula

C6H4N2O4

Synonyms

1,4-Dinitrobenzene
Benzene, 1,4-dinitro- (9CI)
Dithane A-4
p-Dinitrobenzene
p-Dinitrobenzene (ACGIH:OSHA)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium5 µg/plate (+enzymatic activation step)CRNGDP 6,727,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lethal dose (50 percent kill): 56 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaJPETAB 80,31,1944
oral/cat lowest published lethal dose: 29 mg/kg85KYAH 11,516,1989
oral/rat lowest published toxic dose: 5 mg/kgLung, Thorax, or Respiration: Cyanosis

Blood: Changes in spleen
TXAPA9 92,54,1988
oral/rat lowest published lethal dose: 50 mg/kgEye: Other eye effects

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0546024

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.15 ppm (skin)DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.15 ppm (1 mg/m3) (skin)DTLVS* 3,92,1971
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.15 ppm (1 mg/m3), JUL2008
Occupational Exposure Limit-DENMARKtime-weighted average 0.15 ppm (1 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.15 ppm (1 mg/m3), FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.15 ppm (1 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.15 ppm (1 mg/m3), skin, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.15 ppm (1 mg/m3), skin, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.15 ppm (1 mg/m3), skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,15 ppm (1 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 0.15 ppm (1 mg/m3);short term exposure limit 0.3 ppm (2 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.15 ppm (1 mg/m3), KZG-week 0.3 ppm (2 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.15 ppm (1 mg/m3);short term exposure limit 0.5 ppm (3.5 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-DINITROBENZENE-air10H time-weighted average 1 mg/m3 (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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