Sulfuryl fluoride
RTECS #
WT5075000
CAS #
Updated
December 2015
Molecular Weight
102.06
Molecular Formula
F2O2S
Synonyms
Fluorure de sulfuryle (French)
Sulfuric oxyfluoride
Sulfuryl difluoride
Sulfuryl fluoride (ACGIH:OSHA)
Vikane
Vikane fumigant
Sulfuric oxyfluoride
Sulfuryl difluoride
Sulfuryl fluoride (ACGIH:OSHA)
Vikane
Vikane fumigant
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 225 ppm/6H (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | FAATDF 13,79,1989 |
| inhalation/rabbit | 225 ppm/6H (6-18D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | FAATDF 13,79,1989 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | Lowest published lethal concentration: 1200 ppm/1H | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Cyanosis | AMPMAR 34,581,1973 |
| inhalation/mouse | lethal concentration (50 percent kill): 642 ppm/4H | FEREAC 67,7158,2002 | |
| inhalation/rabbit | Lowest published lethal concentration: 5000 ppm/1H | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Cyanosis | AMPMAR 34,581,1973 |
| inhalation/rat | lethal concentration (50 percent kill): 991 ppm/4H | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Cyanosis | FAATDF 7,664,1986 |
| oral/guinea pig | lethal dose (50 percent kill): 100 mg/kg | DOWCC* | |
| oral/rat | lethal dose (50 percent kill): 100 mg/kg | 85ARAE 3,15,1976/1977 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/Dog | lowest published toxic concentration: 1106 mg/kg/2W- intermittent | Behavioral: Tremor Behavioral: Tetany Lung, Thorax, or Respiration: Other changes | FEREAC 69,3240,2004 |
| inhalation/Dog | lowest published toxic concentration: 1134 mg/kg/2W- intermittent | Behavioral: Tremor Behavioral: Tetany Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FEREAC 69,3240,2004 |
| inhalation/Dog | lowest published toxic concentration: 4500 mg/kg/90D- intermittent | Brain and Coverings: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FEREAC 69,3240,2004 |
| inhalation/Dog | lowest published toxic concentration: 4590 mg/kg/90D- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Tremor Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FEREAC 69,3240,2004 |
| inhalation/Dog | lowest published toxic concentration: 7300 mg/kg/1Y- intermittent | Lung, Thorax, or Respiration: Other changes Musculoskeletal: Changes in teeth and supporting structures Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FEREAC 69,3240,2004 |
| inhalation/mouse | lowest published toxic concentration: 55348 mg/kg/1.5Y- intermittent | Brain and Coverings: Other degenerative changes Endocrine: Evidence of thyroid hyperfunction Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FEREAC 69,3240,2004 |
| inhalation/mouse | lowest published toxic concentration: 55348 mg/kg/1.5Y- intermittent | Brain and Coverings: Other degenerative changes Cardiac: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | FEREAC 69,3240,2004 |
| inhalation/mouse | lowest published toxic concentration: 80 ppm/6H/78W- intermittent | Brain and Coverings: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TOXID9 14,394,1994 |
| inhalation/mouse | lowest published toxic concentration: 10890 mg/kg/90D- intermittent | Brain and Coverings: Other degenerative changes Endocrine: Evidence of thyroid hyperfunction Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FEREAC 69,3240,2004 |
| inhalation/rabbit | lowest published toxic concentration: 337 ppm/6H/13W- intermittent | Liver: Changes in liver weight Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Changes in: Other metals | FAATDF 12,540,1989 |
| inhalation/rabbit | lowest published toxic concentration: 1260 mg/kg/2W- intermittent | Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Other changes | FEREAC 69,3240,2004 |
| inhalation/rabbit | lowest published toxic concentration: 2610 mg/kg/90D- intermittent | Liver: Changes in liver weight Musculoskeletal: Changes in teeth and supporting structures Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FEREAC 69,3240,2004 |
| inhalation/rabbit | lowest published toxic concentration: 2520 mg/kg/90D- intermittent | Brain and Coverings: Other degenerative changes Liver: Changes in liver weight Musculoskeletal: Changes in teeth and supporting structures | FEREAC 69,3240,2004 |
| inhalation/rat | lowest published toxic concentration: 10220 mg/kg/2Y- intermittent | Musculoskeletal: Changes in teeth and supporting structures | FEREAC 69,3240,2004 |
| inhalation/rat | lowest published toxic concentration: 45260 mg/kg/2Y- intermittent | Kidney, Ureter, and Bladder: Other changes Musculoskeletal: Changes in teeth and supporting structures Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | FEREAC 69,3240,2004 |
| inhalation/rat | lowest published toxic concentration: 5110 mg/kg/1Y- intermittent | Musculoskeletal: Changes in teeth and supporting structures | FEREAC 69,3240,2004 |
| inhalation/rat | lowest published toxic concentration: 7200 mg/kg/90D- intermittent | Musculoskeletal: Changes in teeth and supporting structures | FEREAC 69,3240,2004 |
| inhalation/rat | lowest published toxic concentration: 3486 mg/kg/2W- intermittent | Kidney, Ureter, and Bladder: Other changes Kidney, Ureter, and Bladder: Changes in kidney weight | FEREAC 69,3240,2004 |
| inhalation/rat | lowest published toxic concentration: 600 ppm/6H/2W- intermittent | Kidney, Ureter, and Bladder: Proteinuria Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 12,540,1989 |
| inhalation/rat | lowest published toxic concentration: 300 ppm/6H/13W- intermittent | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Other changes Kidney, Ureter, and Bladder: Other changes in urine composition | FAATDF 12,540,1989 |
| inhalation/rat | lowest published toxic concentration: 80 ppm/6H/2Y- intermittent | Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TOXID9 14,394,1994 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2.5 mg(F)/m3 | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 5 ppm;short term exposure limit 10 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | HETOEA 26,321,2007 | |
| TOXICOLOGY REVIEW | TXCYAC 307,3,2013 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | RED Completed | RBREV* -,150,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 5 ppm (20 mg/m3) | DTLVS* 3,241,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 2.5 mg(F)/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 5 ppm (21 mg/m3), short term exposure limit 10 ppm (42 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 ppm (21 mg/m3);KZW 10 ppm (42 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 2.5 mg(F)/m3, MAR2002 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 5 ppm (21 mg/m3), short term exposure limit 10 ppm (43 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 ppm (20 mg/m3), MAY2011 | |
| Occupational Exposure Limit-EC | time-weighted average 2.5 mg(F)/m3, JUN2000 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 2.5 mg(F)/m3, NOV2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 5 ppm (21 mg/m3), short term exposure limit 10 ppm (42 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 5 ppm (20 mg/m3), FEB2006 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 ppm (20 mg/m3), NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 5 ppm (20 mg/m3), short term exposure limit 10 ppm (40 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 5 ppm (20 mg/m3);short term exposure limit 10 ppm (40 mg/m3), 2004 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 2.5 mg(F)/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 ppm (21 mg/m3), short term exposure limit 10 ppm (42 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 2.5 mg(F)/m3, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 5 ppm (20 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 5 ppm (21 mg/m3); short term exposure limit 10 ppm (42 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 1 mg(HF)/m3, MAC(short term exposure limit) 3 mg(HF)/m3, JAN1999 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 2 mg(F)/m3, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 1 mg(F)/m3, KZG-week 4 mg(F)/m3, inhal, skin, JAN2011 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 5 ppm (20 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 20 mg/m3, 2003 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 5 ppm (21 mg/m3);short term exposure limit 10 ppm (42 mg/m3), OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 ppm (20 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 5 ppm (20 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 ppm (20 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 ppm (20 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SULFURYL FLUORIDE-air | 10H time-weighted average 5 ppm;short term exposure limit 10 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 70960; Number of Industries 2; Total Number of Facilities 350; Number of Occupations 3; Total Number of Employees Exposed 5136 | |
| National Occupational Hazard Survey 1974 | Hazard Code 70960; Number of Industries 1; Total Number of Facilities 11; Number of Occupations 3; Total Number of Employees Exposed 357 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| NIOSH Analytical Method, 1994: Sulfuryl fluoride, 6012 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health