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Registry of Toxic Effects of Chemical Substances (RTECS)

Sulfuryl fluoride

RTECS #

WT5075000

CAS #

2699-79-8

Updated

December 2015

Molecular Weight

102.06

Molecular Formula

F2O2S

Synonyms

Fluorure de sulfuryle (French)
Sulfuric oxyfluoride
Sulfuryl difluoride
Sulfuryl fluoride (ACGIH:OSHA)
Vikane
Vikane fumigant

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 225 ppm/6H (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FAATDF 13,79,1989
inhalation/rabbit 225 ppm/6H (6-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
FAATDF 13,79,1989

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 1200 ppm/1HBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis
AMPMAR 34,581,1973
inhalation/mouse lethal concentration (50 percent kill): 642 ppm/4HFEREAC 67,7158,2002
inhalation/rabbit Lowest published lethal concentration: 5000 ppm/1HBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis
AMPMAR 34,581,1973
inhalation/rat lethal concentration (50 percent kill): 991 ppm/4HBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Cyanosis
FAATDF 7,664,1986
oral/guinea pig lethal dose (50 percent kill): 100 mg/kgDOWCC*
oral/rat lethal dose (50 percent kill): 100 mg/kg85ARAE 3,15,1976/1977

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 1106 mg/kg/2W- intermittentBehavioral: Tremor

Behavioral: Tetany

Lung, Thorax, or Respiration: Other changes
FEREAC 69,3240,2004
inhalation/Dog lowest published toxic concentration: 1134 mg/kg/2W- intermittentBehavioral: Tremor

Behavioral: Tetany

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 69,3240,2004
inhalation/Dog lowest published toxic concentration: 4500 mg/kg/90D- intermittentBrain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 69,3240,2004
inhalation/Dog lowest published toxic concentration: 4590 mg/kg/90D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Tremor

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 69,3240,2004
inhalation/Dog lowest published toxic concentration: 7300 mg/kg/1Y- intermittentLung, Thorax, or Respiration: Other changes

Musculoskeletal: Changes in teeth and supporting structures

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 69,3240,2004
inhalation/mouse lowest published toxic concentration: 55348 mg/kg/1.5Y- intermittentBrain and Coverings: Other degenerative changes

Endocrine: Evidence of thyroid hyperfunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 69,3240,2004
inhalation/mouse lowest published toxic concentration: 55348 mg/kg/1.5Y- intermittentBrain and Coverings: Other degenerative changes

Cardiac: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FEREAC 69,3240,2004
inhalation/mouse lowest published toxic concentration: 80 ppm/6H/78W- intermittentBrain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 14,394,1994
inhalation/mouse lowest published toxic concentration: 10890 mg/kg/90D- intermittentBrain and Coverings: Other degenerative changes

Endocrine: Evidence of thyroid hyperfunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 69,3240,2004
inhalation/rabbit lowest published toxic concentration: 337 ppm/6H/13W- intermittentLiver: Changes in liver weight

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Changes in: Other metals
FAATDF 12,540,1989
inhalation/rabbit lowest published toxic concentration: 1260 mg/kg/2W- intermittentBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes
FEREAC 69,3240,2004
inhalation/rabbit lowest published toxic concentration: 2610 mg/kg/90D- intermittentLiver: Changes in liver weight

Musculoskeletal: Changes in teeth and supporting structures

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 69,3240,2004
inhalation/rabbit lowest published toxic concentration: 2520 mg/kg/90D- intermittentBrain and Coverings: Other degenerative changes

Liver: Changes in liver weight

Musculoskeletal: Changes in teeth and supporting structures
FEREAC 69,3240,2004
inhalation/rat lowest published toxic concentration: 10220 mg/kg/2Y- intermittentMusculoskeletal: Changes in teeth and supporting structuresFEREAC 69,3240,2004
inhalation/rat lowest published toxic concentration: 45260 mg/kg/2Y- intermittentKidney, Ureter, and Bladder: Other changes

Musculoskeletal: Changes in teeth and supporting structures

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FEREAC 69,3240,2004
inhalation/rat lowest published toxic concentration: 5110 mg/kg/1Y- intermittentMusculoskeletal: Changes in teeth and supporting structuresFEREAC 69,3240,2004
inhalation/rat lowest published toxic concentration: 7200 mg/kg/90D- intermittentMusculoskeletal: Changes in teeth and supporting structuresFEREAC 69,3240,2004
inhalation/rat lowest published toxic concentration: 3486 mg/kg/2W- intermittentKidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight
FEREAC 69,3240,2004
inhalation/rat lowest published toxic concentration: 600 ppm/6H/2W- intermittentKidney, Ureter, and Bladder: Proteinuria

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 12,540,1989
inhalation/rat lowest published toxic concentration: 300 ppm/6H/13W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition
FAATDF 12,540,1989
inhalation/rat lowest published toxic concentration: 80 ppm/6H/2Y- intermittentKidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 14,394,1994

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2.5 mg(F)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 ppm;short term exposure limit 10 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWHETOEA 26,321,2007
TOXICOLOGY REVIEWTXCYAC 307,3,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,150,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 5 ppm (20 mg/m3)DTLVS* 3,241,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2.5 mg(F)/m3, JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 ppm (21 mg/m3), short term exposure limit 10 ppm (42 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (21 mg/m3);KZW 10 ppm (42 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 2.5 mg(F)/m3, MAR2002
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (21 mg/m3), short term exposure limit 10 ppm (43 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (20 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 2.5 mg(F)/m3, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 2.5 mg(F)/m3, NOV2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (21 mg/m3), short term exposure limit 10 ppm (42 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 5 ppm (20 mg/m3), FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (20 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 5 ppm (20 mg/m3), short term exposure limit 10 ppm (40 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 ppm (20 mg/m3);short term exposure limit 10 ppm (40 mg/m3), 2004
Occupational Exposure Limit-MEXICOtime-weighted average 2.5 mg(F)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 ppm (21 mg/m3), short term exposure limit 10 ppm (42 mg/m3), JAN2002
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2.5 mg(F)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 ppm (21 mg/m3); short term exposure limit 10 ppm (42 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1 mg(HF)/m3, MAC(short term exposure limit) 3 mg(HF)/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 2 mg(F)/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1 mg(F)/m3, KZG-week 4 mg(F)/m3, inhal, skin, JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (20 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 20 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 ppm (21 mg/m3);short term exposure limit 10 ppm (42 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 ppm (20 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 5 ppm (20 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 ppm (20 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 ppm (20 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SULFURYL FLUORIDE-air10H time-weighted average 5 ppm;short term exposure limit 10 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 70960; Number of Industries 2; Total Number of Facilities 350; Number of Occupations 3; Total Number of Employees Exposed 5136
National Occupational Hazard Survey 1974Hazard Code 70960; Number of Industries 1; Total Number of Facilities 11; Number of Occupations 3; Total Number of Employees Exposed 357

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NIOSH Analytical Method, 1994: Sulfuryl fluoride, 6012
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