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Registry of Toxic Effects of Chemical Substances (RTECS)

Phthalic acid, dibutyl ester

RTECS #

TI0875000

CAS #

84-74-2

Updated

October 2017

Molecular Weight

278.38

Molecular Formula

C16H22O4

Synonyms

Benzene-o-dicarboxylic acid di-n-butyl ester
Celluflex DPB
DBP (ester)
Dibutyl 1,2-benzenedicarboxylate
Dibutyl o-phthalate
Dibutyl phthalate
Dibutyl phthalate (ACGIH:OSHA)
Di-n-butyl phthalate
Di-n-butylester kyseliny ftalove (Czech)
Elaol
Ergoplast FOB
Genoplast B
Hatcol DBP
Hexaplas M/B
Kodaflex DBP
Monocizer DBP
n-Butylphthalate
o-Benzenedicarboxylic acid, dibutyl ester
Palatinol C
Polycizer DBP
PX 104
RCRA waste number U069
Staflex DBP
Unimoll DB
Vestinol C
Witcizer 300

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisfibroblast/hamster30 mg/L/24HMUREAV 48,337,1977
Cytogenetic Analysisovary/non-mammalian species0.1 µmol/L/3HMUTAEX 14,375,1999
DNA Damageother cell types/human216 µmol/L/60MEMMUEG 35,9,2000
DNA Damagelymphocyte/human354 mmol/L/60MTCMUD8 21,189,2001
DNA Damagelymphocyte/human354 mmol/LMUREAV 467,21,2000
DNA Damageother cell types/human354 mmol/LMUREAV 467,21,2000
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+enzymatic activation step)JTEHD6 16,61,1985

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 1017 mg/kg (5-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)JPMSAE 61,51,1972
intraperitoneal/rat 305 mg/kg (5-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JPMSAE 61,51,1972
intraperitoneal/rat 6 gm/kg (3-9D pregnant)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)EVHPAZ 3,91,1973
intraperitoneal/rat 6 mL/kg (3-9D pregnant)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)EVHPAZ 3,91,1973
oral/rat 11.2 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB92111996
oral/rat 77.5 gm/kg (17W prior to copulation)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB92111996
oral/rat 2.3 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)NTIS** #PB92111996
oral/rat 66 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB92111996
oral/rat 651 mg/kg (multigenerations)Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
NTIS** #PB92111996
oral/rat 651 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB92111996
oral/rat 3500 mg/kg (12-18D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemREPTED 16,10,2002
oral/rat 5000 mg/kg (12-21D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 16,10,2002
oral/rat 16.5 gm/kg (7-22D preg/17D after birth)Reproductive: Effects on newborn: Other postnatal measures or effectsJJTHEC 65(A),813,2002
oral/rat 5500 mg/kg (7-17D after birth)Reproductive: Effects on newborn: BehavioralREPTED 17,475,2003
oral/rat 4000 mg/kg (12-19D pregnant)Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)TOSCF2 73,431,2003
oral/rabbit 5600 mg/kg (15-29D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
TOSCF2 72,301,2003
oral/rat 28 gm/kg (4W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)REPTED 18,35,2004
oral/rat 600 mg/kg (multigeneration)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Other developmental abnormalities
REPTED 18,1,2004
oral/mouse 7200 mg/kg (1-18D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Central nervous system
OEKSDJ 8,29,1977
oral/mouse 8640 mg/kg (1-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)EVHPAZ 45,65,1982
oral/mouse 20 gm/kg (6-13D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)TCMUD8 7,29,1987
oral/mouse 16800 mg/kg (7D male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male
TOLED5 5,413,1980
oral/guinea pig 14 gm/kg (7D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductTOLED5 11,141,1982
oral/rat 24 gm/kg (20D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
WDZAEK 3,153,1989
oral/rat 6750 mg/kg (0-8D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
CGANE7 39,189,1999
oral/rat 2250 mg/kg (7-9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
TXCYAC 86,163,1994
oral/rat 2520 mg/kg (1-21D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)TXAPA9 26,253,1973
oral/rat 8820 mg/kg (7-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TOLED5 69,197,1993
oral/rat 19 gm/kg (3-22D preg/3-20D after birth)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
TOSCF2 43,47,1998
oral/rat 1500 mg/kg (15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JJATDK 17,223,1997
oral/rat 6750 mg/kg (0-8D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
REPTED 14,13,2000
oral/rat 23 mg/kg (15-22D preg/15D after birth)Reproductive: Specific developmental abnormalities: Urogenital systemTXCYAC 203,221,2004
oral/rat 230 mg/kg (15-22D preg/15D after birth)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Other postnatal measures or effects
TXCYAC 203,221,2004
oral/rat 1164 mg/kg (75D prior to copulation/1-22D pregnant)Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Urogenital system
TXCYAC 205,131,2004
oral/rat 4850 mg/kg (75D prior to copulation/1-22D pregnant)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
TXCYAC 205,131,2004
oral/rat 270 mg/kg (12-20D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemTOXID9 44,281,2005
oral/rat 2500 mg/kg (10-19D pregnant)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 78,118,2004
oral/rat 4000 mg/kg (12-19D pregnant)Reproductive: Specific developmental abnormalities: Endocrine systemTOXID9 78,188,2004
oral/rat 3500 mg/kg (13-19D pregnant)Reproductive: Specific developmental abnormalities: Endocrine systemTOXID9 78,188,2004
oral/rat 3000 mg/kg (14-19D pregnant)Reproductive: Specific developmental abnormalities: Endocrine systemTOXID9 78,188,2004
oral/rat 2500 mg/kg (15-19D pregnant)Reproductive: Specific developmental abnormalities: Endocrine systemTOXID9 78,188,2004
oral/rat 2000 mg/kg (16-19D pregnant)Reproductive: Specific developmental abnormalities: Endocrine systemTOXID9 78,188,2004
oral/rat 1500 mg/kg (17-19D pregnant)Reproductive: Specific developmental abnormalities: Endocrine systemTOXID9 78,188,2004
oral/rat 1000 mg/kg (18-19D pregnant)Reproductive: Specific developmental abnormalities: Endocrine systemTOXID9 78,188,2004
oral/rat 500 mg/kg (19D pregnant)Reproductive: Specific developmental abnormalities: Endocrine systemTOXID9 78,188,2004
oral/rat 3000 mg/kg (12-17D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemTOXID9 78,190,2004
oral/rat 3750 mg/kg (14-18D pregnant)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 78,282,2004
oral/rat 4000 mg/kg (12-19D pregnant)Reproductive: Other effects on female

Reproductive: Other effects to embryo or fetus
TOXID9 78,282,2004
oral/rat 4000 mg/kg (12-19D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicTOXID9 1,72,2001
oral/rat 5000 mg/kg (12-21D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
TOXID9 60,216,2001
oral/rat 2500 mg/kg (14-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
TOXID9 90,316,2006
oral/rat 3750 mg/kg (14-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TXCYAC 240,86,2007
oral/rat 2500 mg/kg (14-18D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TXCYAC 232,286,2007
oral/rat 2500 mg/kg (14-18D pregnant)Reproductive: Effects on newborn: Delayed effectsTXCYAC 232,286,2007
oral/rat 1250 mg/kg (14-18D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicTXCYAC 232,286,2007
oral/rat 5000 mg/kg (14-18D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathTXCYAC 232,286,2007
oral/rat 3750 mg/kg (14-18D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)TXCYAC 232,286,2007
oral/rat 83 gm/kg (129D pre-15D after birth)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on newborn: Other neonatal measures or effects
TOSCF2 93,189,2006
oral/rat 80 gm/kg (61D male/61D pre-15D after birth)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)TOSCF2 93,189,2006
oral/rat 53.5 gm/kg (94D pre-15D after birth)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
TOSCF2 93,189,2006
oral/rat 60.5 gm/kg (132D prior to copulation/1-13D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
TOSCF2 93,189,2006
oral/rat 121 gm/kg (132D prior to copulation/1-13D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
TOSCF2 93,189,2006
oral/rat 5000 mg/kg (12-21D pregnant)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
TOPADD 31,397,2003
oral/rat 5000 mg/kg (12-21D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Physical
TOPADD 31,397,2003
oral/rat 4000 mg/kg (12-19D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemTOPADD 31,397,2003
oral/rat 5000 mg/kg (12-21D pregnant)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Specific developmental abnormalities: Urogenital system
TOPADD 32,79,2004
oral/rat 5000 mg/kg (12-21D pregnant)Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
TOPADD 32,79,2004
oral/rat 1000 mg/kg (15-16D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
BDERB* 74,277,2005
oral/rat 1000 mg/kg (16-17D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
BDERB* 74,277,2005
oral/rat 1000 mg/kg (16-17D pregnant)Reproductive: Effects on newborn: Delayed effectsBDERB* 74,277,2005
oral/rat 1000 mg/kg (17-18D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
BDERB* 74,277,2005
oral/rat 1000 mg/kg (17-18D pregnant)Reproductive: Effects on newborn: Delayed effectsBDERB* 74,277,2005
oral/rat 1000 mg/kg (18-19D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
BDERB* 74,277,2005
oral/rat 1000 mg/kg (19-20D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
BDERB* 74,277,2005
oral/rat 1000 mg/kg (14-15D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
BDERB* 74,277,2005
oral/rat 5000 mg/kg (12-21D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemTERP1* -,297,2004
oral/rat 900 mg/kg (13-21D pregnant)Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 -,10,2008
oral/rat 4500 mg/kg (13-21D pregnant)Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 -,10,2008
oral/rat 500 mg/kg (19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system
TXCYAC 255,80,2009
oral/rat 4000 mg/kg (12-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOXID9 -,32,2009
oral/mouse 2500 mg/kg (12-21D pregnant)Reproductive: Effects on newborn: Germ cell effects (in offspring)TOXID9 -,352,2009
oral/rat 4000 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TOXID9 -,354,2009
oral/rat 4000 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTOXID9 -,354,2009
oral/rat 3750 mg/kg (14-18D pregnant)Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Biochemical and metabolic
TXCYAC 260,120,2009
oral/rat 900 mg/kg (12-20D pregnant)Reproductive: Other effects to embryo or fetusREPTED 29,99,2010
oral/rat 3000 mg/kg (12-20D preg/21D after birth)Reproductive: Other effects to embryo or fetusREPTED 29,99,2010
oral/rat 4656 mg/kg (12-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system
BDERB* 86,345,2009
oral/rat 3100 mg/kg (12D preg-21D after birth)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Biochemical and metabolic
TXCYAC 262,215,2009
oral/rat 5000 mg/kg (12-21D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
REPTED 26,107,2008
oral/rat 5950 mg/kg (12-18D pregnant)Reproductive: Specific developmental abnormalities: Gastrointestinal system

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Other developmental abnormalities
TXCYAC 290,322,2011
oral/rat 5950 mg/kg (12-18D pregnant)Reproductive: Effects on newborn: Other neonatal measures or effects

Reproductive: Effects on newborn: Physical
TXCYAC 290,322,2011
oral/rat 3750 mg/kg (14-18D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects
TXCYAC 293,53,2012
oral/mouse 46200 mg/kg (1-21D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)ENVRAL 22,245,1980
oral/rat 2 gm/kg (15D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Sex ratio
TOSCF2 45,212,1998
oral/rat 1.5 gm/kg (15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TOSCF2 45,212,1998
oral/rat 501 mg/kg (10D pregnant)Reproductive: Other effects to embryo or fetusPHTOEH 89,104,2001
unreported route/rat 2500 mg/kg (14-18D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemTOXID9 -,117,2009
unreported route/rat 1000 mg/kg (16-19D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemTOXID9 42,176,1998
unreported route/rat 1000 mg/kg (15-16D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemTOXID9 44,113,2005
unreported route/rat 1000 mg/kg (16-17D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemTOXID9 44,113,2005
unreported route/rat 1000 mg/kg (17-18D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemTOXID9 44,113,2005
unreported route/rat 1000 mg/kg (18-19D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemTOXID9 44,113,2005
unreported route/rat 1000 mg/kg (19-20D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemTOXID9 44,113,2005

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 219 gm/kg/1Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Other reproductive system tumors
TIHEEC 25,189,2009

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, fibroblast Inhibitor Concentration Low: 1 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 65,105,2014
In Vitro/Human, lung tumor Inhibitor Concentration (50 percent kill): 94.9 mg/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 135,492,2011
In Vitro/Human, lung tumor Inhibitor Concentration (50 percent kill): 71.2 mg/L/72HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 135,492,2011
In Vitro/Human, skin Inhibitor Concentration Low: 1 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 65,105,2014
In Vitro/jqaInhibitor Concentration (50 percent kill): 150 µmol/L/24HEndocrine: Other changesFCTOD7 96,107,2016
In Vitro/jrdInhibitor Concentration Low: 100 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 217,50,2013
inhalation/mouse lethal concentration (50 percent kill): 25 gm/m3Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma
ENTOX* -,1,2005
inhalation/mouse lethal concentration (50 percent kill): 25 gm/m3/2H85GMAT -,44,1982
inhalation/rat lethal concentration (50 percent kill): 4250 mg/m3GTPZAB 17(8),26,1973
intramuscular/rat lethal dose (50 percent kill): >8 gm/kg14CYAT 2,1904,1963
intraperitoneal/mouse lethal dose (50 percent kill): 3570 mg/kgJSCCA5 28,667,1977
intraperitoneal/rat lethal dose (50 percent kill): 4 gm/kgENTOX* -,1,2005
intraperitoneal/rat lethal dose (50 percent kill): 3050 µL/kgJPMSAE 61,51,1972
intravenous/mouse lethal dose (50 percent kill): 720 mg/kgKEKHB8 (3),19,1973
oral/guinea pig lethal dose (50 percent kill): 10 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Withdrawal

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 24(3),25,1980
oral/human lowest published toxic dose: 140 mg/kgBehavioral: Hallucinations, distorted perceptions

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Other changes
SMWOAS 84,1243,1954
oral/mammal (species unspecified) lethal dose (50 percent kill): 5 gm/kgGISAAA 39(4),86,1974
oral/mouse lethal dose (50 percent kill): 3474 mg/kgWDZAEK 5,264,1991
oral/rat lethal dose (50 percent kill): 7499 mg/kgWDZAEK 5,264,1991
oral/rat lowest published toxic dose: 2394 mg/kgReproductive: Paternal effects: Testes, epididymis, sperm ductTOLED5 138,215,2003
oral/rat lowest published toxic dose: 52 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 15,123,1979
skin/rabbit lethal dose (50 percent kill): >20 mL/kgUCDS** 12/29/1971
skin/rat lowest published lethal dose: 6 gm/kg85GMAT -,44,1982
unreported route/mouse lethal dose (50 percent kill): 8140 mg/kgBehavioral: General anesthetic

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
GISAAA 55(6),86,1990
unreported route/rat lethal dose (50 percent kill): 9410 mg/kgBehavioral: General anesthetic

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
GISAAA 55(6),86,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 900 mg/m3/6H/35D- intermittentBrain and Coverings: Changes in brain weight

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 17(8),26,1973
intramuscular/mouse lowest published toxic dose: 151200 mg/kg/18W- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB85144798
intramuscular/mouse lowest published toxic dose: 151200 mg/kg/18W- continuousLiver: Changes in liver weight

Related to Chronic Data: Changes in uterine weight
NTIS** #PB85144798
intramuscular/rat lowest published toxic dose: 4557 mg/kg/1W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB92111996
intramuscular/rat lowest published toxic dose: 77469 mg/kg/17W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
NTIS** #PB92111996
intramuscular/rat lowest published toxic dose: 77469 mg/kg/17W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct
NTIS** #PB92111996
intraperitoneal/rat lowest published toxic dose: 12 mL/kg/7D- intermittentReproductive: Maternal effects: Parturition

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
EVHPAZ 3,91,1973
oral/mouse lowest published toxic dose: 350 mg/kg/14D- intermittentBehavioral: Alteration of operant conditioning

Brain and Coverings: Other degenerative changes
FCTOD7 94,221,2016
oral/mouse lowest published toxic dose: 54600 mg/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NTPTR* NIH-95-3353
oral/mouse lowest published toxic dose: 175 mg/kg/14D- intermittentBehavioral: Change in motor activity (specific assay)FCTOD7 94,221,2016
oral/mouse lowest published toxic dose: 17000 mg/kg/7D- intermittentLiver: Changes in liver weight

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 207,149,2005
oral/mouse lowest published toxic dose: 219 gm/kg/1Y- continuousLung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Related to Chronic Data: Changes in testicular weight
TIHEEC 25,189,2009
oral/mouse lowest published toxic dose: 219 gm/kg/1Y- continuousLung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
TIHEEC 25,189,2009
oral/rabbit lowest published toxic dose: 33600 mg/kg/12W- intermittentEndocrine: Androgenic

Endocrine: Changes in thyroid weight

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
TOSCF2 72,301,2003
oral/rat lowest published toxic dose: 3750 mg/kg/15D- intermittentEndocrine: Evidence of thyroid hypofunctionTOSCF2 69,92,2002
oral/rat lowest published toxic dose: 7500 mg/kg/15D- intermittentLiver: Changes in liver weight

Endocrine: Evidence of thyroid hypofunction
TOSCF2 69,92,2002
oral/rat lowest published toxic dose: 15000 mg/kg/15D- intermittentLiver: Changes in liver weight

Endocrine: Evidence of thyroid hypofunction

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
TOSCF2 69,92,2002
oral/rat lowest published toxic dose: 28000 mg/kg/4W- intermittentKidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 18,35,2004
oral/rat lowest published toxic dose: 1680 mg/kg/4W- intermittentNutritional and Gross Metabolic: Changes in: Metabolic alkalosisREPTED 18,35,2004
oral/rat lowest published toxic dose: 7000 mg/kg/4W- intermittentLiver: Changes in liver weightREPTED 18,35,2004
oral/rat lowest published toxic dose: 22500 mg/kg/30D- intermittentEndocrine: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
TOXID9 44,113,2005
oral/rat lowest published toxic dose: 27300 mg/kg/13W- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 203,41,2004
oral/rat lowest published toxic dose: 11250 mg/kg/9D- intermittentRelated to Chronic Data: Changes in ovarian weightREPTED 14,13,2000
oral/rat lowest published toxic dose: 13500 mg/kg/9D- intermittentBehavioral: Alteration of classical conditioning

Endocrine: Estrogenic
REPTED 14,13,2000
oral/rat lowest published toxic dose: 4500 mg/kg/9D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 14,13,2000
oral/rat lowest published toxic dose: 6750 mg/kg/9D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in uterine weight
REPTED 14,13,2000
oral/rat lowest published toxic dose: 28000 mg/kg/10D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
ATSUDG 4,452,1980
oral/rat lowest published toxic dose: 1500 mg/kg/30D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductTXAPA9 248,28,2010
oral/rat lowest published toxic dose: 7500 mg/kg/30D- intermittentEndocrine: Androgenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TXAPA9 248,28,2010
oral/rat lowest published toxic dose: 4500 mg/kg/90D- intermittentEndocrine: Androgenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 248,28,2010
oral/rat lowest published toxic dose: 96750 mg/kg/45D- intermittentEndocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 33(6),102,1968
oral/rat lowest published toxic dose: 42 gm/kg/28D- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
NTIS** OTS0530401
oral/rat lowest published toxic dose: 4 gm/kg/4D- intermittentRelated to Chronic Data: Changes in testicular weightTXAPA9 41,609,1977
oral/rat lowest published toxic dose: 3500 mg/kg/14D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in testicular weight
FCTOD7 71,26,2014
oral/rat lowest published toxic dose: 4000 mg/kg/8D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other
TOXID9 78,282,2004
oral/rat lowest published toxic dose: 33012 mg/kg/12W- intermittentEndocrine: Evidence of thyroid hypofunction

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 213,13,2005
oral/rat lowest published toxic dose: 22500 mg/kg/30D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Metabolism (intermediary): Other
TOXID9 90,219,2006
oral/rat lowest published toxic dose: 22500 mg/kg/30D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TXCYAC 234,103,2007
oral/rat lowest published toxic dose: 15000 mg/kg/30D- intermittentRelated to Chronic Data: Changes in testicular weightTXCYAC 234,103,2007
oral/rat lowest published toxic dose: 3750 mg/kg/5D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTXCYAC 232,286,2007
oral/rat lowest published toxic dose: 96 gm/kg/192D- intermittentEndocrine: Other changesTOSCF2 93,189,2006
oral/rat lowest published toxic dose: 121 gm/kg/145D- intermittentEndocrine: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
TOSCF2 93,189,2006
oral/rat lowest published toxic dose: 60.5 gm/kg/145D- intermittentEndocrine: Changes in pituitary weightTOSCF2 93,189,2006
oral/rat lowest published toxic dose: 27300 mg/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia
NTPTR* NIH-95-3353
oral/rat lowest published toxic dose: 22750 mg/kg/1Y- continuousBehavioral: Food intake (animal)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 26,253,1973
oral/rat lowest published toxic dose: 91000 mg/kg/13W- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 204,109,2004
oral/rat lowest published toxic dose: 38850 mg/kg/12W- intermittentReproductive: Maternal effects: Uterus, cervix, vaginaTXCYAC 205,103,2004
oral/rat lowest published toxic dose: 10000 mg/kg/4W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTPAE7 17,177,2004
oral/rat lowest published toxic dose: 2500 mg/kg/4W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
JTPAE7 17,177,2004
oral/rat lowest published toxic dose: 625 mg/kg/4W- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)JTPAE7 17,177,2004
oral/rat lowest published toxic dose: 15000 mg/kg/30D- intermittentLiver: Changes in liver weight

Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight
JTSCDR 33,299,2008
oral/rat lowest published toxic dose: 26000 mg/kg/65D- intermittentEndocrine: Change in LH

Endocrine: Other changes

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
TOXID9 -,354,2009
oral/rat lowest published toxic dose: 18 gm/kg/9D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
BCLPT* 100,43,2007
oral/rat lowest published toxic dose: 5000 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainREPTED 26,107,2008
oral/rat lowest published toxic dose: 7500 mg/kg/15D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
ARTODN 64,148,1990
oral/rat lowest published toxic dose: 5 gm/kg/10D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
JJTHEC 65,813,2002
oral/rat lowest published toxic dose: 20 gm/kg/10D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JJTHEC 65,813,2002
oral/rat lowest published toxic dose: 700 mg/kg/14D- intermittentEndocrine: Changes in adrenal weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FCTOD7 42,107,2004
oral/rat lowest published toxic dose: 2800 mg/kg/14D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
FCTOD7 42,107,2004
oral/rat lowest published toxic dose: 14 gm/kg/14D- intermittentLiver: Changes in liver weightFCTOD7 42,107,2004
oral/rat lowest published toxic dose: 8000 mg/kg/8D- intermittentEndocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
EVHPAZ 111,139,2003
subcutaneous/rat lowest published toxic dose: 3600 mg/kg/9D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in testicular weight
JTEHF8 67,2045,2004
subcutaneous/rat : 2.5 mg/kg/5D- intermittentEndocrine: EstrogenicTXCYAC 314,65,2013
subcutaneous/rat : 25 mg/kg/5D- intermittentRelated to Chronic Data: Changes in ovarian weight

Endocrine: Effect on menstrual cycle
TXCYAC 314,65,2013
subcutaneous/rat : 2.5 mg/kg/5D- intermittentEndocrine: Estrogenic

Endocrine: Effect on menstrual cycle
TXCYAC 314,65,2013
subcutaneous/rat : 25 mg/kg/5D- intermittentRelated to Chronic Data: Changes in ovarian weightTXCYAC 314,65,2013

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWRREVAH 54,1,1975
TOXICOLOGY REVIEWEVHPAZ 4,3,1973
TOXICOLOGY REVIEWCMTVAS 10(3),49,1973
TOXICOLOGY REVIEWESKHA5 (93),1,1975
TOXICOLOGY REVIEWJACTDZ 4(3),267,1985
TOXICOLOGY REVIEWFAATDF 13,747,1989
TOXICOLOGY REVIEWTXAPA9 197,178,2004
TOXICOLOGY REVIEWREPTED 20,441,2005
TOXICOLOGY REVIEWBPCEM* 16,105,2002
TOXICOLOGY REVIEWENTOX* -,1,2005
TOXICOLOGY REVIEWENTOX* -,258,2005
TOXICOLOGY REVIEWIJTOFN 24,1,2005
TOXICOLOGY REVIEWCRTXB2 36,695,2006
TOXICOLOGY REVIEWREPTED 22,291,2006
TOXICOLOGY REVIEWHUTOX* -,649,1996
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWMUTAEX 17,495,2002
TOXICOLOGY REVIEWRTOPDW 53,90,2009
TOXICOLOGY REVIEWMUTAEX 26,231,2011
TOXICOLOGY REVIEWREPTED 31,363,2011
TOXICOLOGY REVIEWMUREAV 728,118,2011
TOXICOLOGY REVIEWTXCYAC 285,83,2011
TOXICOLOGY REVIEWREPTED 34,298,2012
TOXICOLOGY REVIEWMUREAV 764-765,36,2014
TOXICOLOGY REVIEWTOLED5 201,152,2011
TOXICOLOGY REVIEWTOLED5 202,36,2011
TOXICOLOGY REVIEWNRTXDN 41,112,2014
TOXICOLOGY REVIEWFCTOD7 55,596,2013
TOXICOLOGY REVIEWTXAPA9 261,227,2012
TOXICOLOGY REVIEWNETEEC 36,17,2013
TOXICOLOGY REVIEWTXAPA9 271,336,2013
TOXICOLOGY REVIEWTXAPA9 271,349,2013
TOXICOLOGY REVIEWNETOX* 48,21,2015
TOXICOLOGY REVIEWFCTOD7 86,298,2015

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,270,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 5 mg/m3DTLVS* 3,75,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 mg/m3, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 3 mg/m3, MAY2011
Occupational Exposure Limit-FRANCEVME 5 mg/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.05 ppm (0.58 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 3 mg/m3, NOV2011
Occupational Exposure Limit-INDIAtime-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit-JAPANOccupational Exposure Limit 5 mg/m3, s2 sen, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 5 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 mg/m3;short term exposure limit 10 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 3 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 3 mg/m3;short term exposure limit 5 mg/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 ppm (0.58 mg/m3), KZG-week 0.1 ppm (1.16 mg/m3), inhal, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 mg/m3;short term exposure limit 10 mg/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 5 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIBUTYL PHTHALATE-air10H time-weighted average 5 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 80248; Number of Industries 199; Total Number of Facilities 31502; Number of Occupations 138; Total Number of Employees Exposed 512631; Total Number of Female Employees Exposed 198249
National Occupational Hazard Survey 1974Hazard Code 80248; Number of Industries 192; Total Number of Facilities 28100; Number of Occupations 114; Total Number of Employees Exposed 258823

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2001/109104/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-reversion
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Dibutyl phthalate, 5020
NTP Carcinogenesis studies; test completed (peer review), October 2000
NTP Toxicity studies, RPT# TOX-30, October 2000
On EPA IRIS database
OSHA ANALYTICAL METHOD #104
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