Oxirane, ((2-propenyloxy)methyl)-
RTECS #
RR0875000
CAS #
Updated
December 2018
Molecular Weight
114.16
Molecular Formula
C6H10O2
Synonyms
1-(Allyloxy)-2,3-epoxypropane
1,2-Epoxy-3-allyloxypropane
1-Allilossi-2,3 epossipropano (Italian)
1-Allyloxy-2,3-epoxy-propaan (Dutch)
1-Allyloxy-2,3-epoxypropan (German)
AGE (OSHA)
Allil-glicidil-etere (Italian)
Allyl 2,3-epoxypropyl ether
Allyl glycidol ether
Allyl glycidyl ether
Allyl glycidyl ether (ACGIH:OSHA)
Allylglycidaether (German)
Ether, allyl 2,3-epoxypropyl
Glycidyl allyl ether
NCI-C56666
Oxyde d'allyle et de glycidyle (French)
Propane, 1-(allyloxy)-2,3-epoxy-
1,2-Epoxy-3-allyloxypropane
1-Allilossi-2,3 epossipropano (Italian)
1-Allyloxy-2,3-epoxy-propaan (Dutch)
1-Allyloxy-2,3-epoxypropan (German)
AGE (OSHA)
Allil-glicidil-etere (Italian)
Allyl 2,3-epoxypropyl ether
Allyl glycidol ether
Allyl glycidyl ether
Allyl glycidyl ether (ACGIH:OSHA)
Allylglycidaether (German)
Ether, allyl 2,3-epoxypropyl
Glycidyl allyl ether
NCI-C56666
Oxyde d'allyle et de glycidyle (French)
Propane, 1-(allyloxy)-2,3-epoxy-
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 97 mg | severe | AMIHAB 14,250,1956 |
| eye /rabbit | 750 µg/24H | severe | 85JCAE -,772,1986 |
| skin /rabbit | 485 mg/3D | moderate | AMIHAB 14,250,1956 |
| skin /rabbit | 2 mg/24H | severe | 85JCAE -,772,1986 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | ovary/hamster | 64800 µg/L | NTPTR* NTP-TR-376,1990 |
| DNA Damage | /Escherichia coli | 1 µmol/L | ARTODN 46,277,1980 |
| morphological transform | fibroblast/mouse | 0.00001 pph/21D (-enzymatic activation step) | EMMUEG 37,231,2001 |
| mutation in microorganisms | /Klebsiella pneumoniae | 500 µmol/L (-enzymatic activation step) | MUREAV 89,269,1981 |
| mutation in microorganisms | /Salmonella typhimurium | 100 µg/plate (+enzymatic activation step) | NTPTR* NTP-TR-376,1990 |
| mutation in microorganisms | /Escherichia coli | 20 µmol/L (-enzymatic activation step) | ARTODN 46,277,1980 |
| other mutation test systems | /Escherichia coli | 3300 µmol/L | MUREAV 231,205,1990 |
| sex chromosome loss and nondisjunction | oral/Drosophila melanogaster | 5500 ppm | ENMUDM 7,349,1985 |
| sister chromatid exchange | ovary/hamster | 3300 µg/L | NTPTR* NTP-TR-376,1990 |
| sister chromatid exchange | lung/hamster | 625 µmol/L | MUREAV 249,55,1991 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 10 ppm/6H/2Y- intermittent | Tumorigenic: Neoplastic by RTECS criteria Olfaction: Tumors | NTPTR* NTP-TR-376,1990 |
| inhalation/mouse | lowest published toxic concentration: 618 mg/kg/103W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Olfaction: Tumors | NTIS** PB90-260027 |
| inhalation/rat | lowest published toxic concentration: 10 ppm/6H/2Y- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Olfaction: Tumors | NTPTR* NTP-TR-376,1990 |
| inhalation/rat | lowest published toxic concentration: 309 mg/kg/103W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Olfaction: Tumors | NTIS** PB90-260027 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lethal concentration (50 percent kill): 270 ppm/4H | Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands | AMIHAB 14,250,1956 |
| inhalation/rat | lethal concentration (50 percent kill): 670 ppm/8H | Eye: Corneal damage Lung, Thorax, or Respiration: Acute pulmonary edema Gastrointestinal: Changes in structure or function of salivary glands | AMIHAB 14,250,1956 |
| oral/mouse | lethal dose (50 percent kill): 390 mg/kg | Brain and Coverings: Recordings from specific areas of CNS Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia | AMIHAB 14,250,1956 |
| oral/rat | lethal dose (50 percent kill): 1600 mg/kg | Brain and Coverings: Recordings from specific areas of CNS Behavioral: Change in motor activity (specific assay) Behavioral: Ataxia | AMIHAB 14,250,1956 |
| skin/rabbit | lethal dose (50 percent kill): 2550 mg/kg | AMIHAB 14,250,1956 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 50 ppm/6H/14D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-376,1990 |
| inhalation/mouse | lowest published toxic concentration: 309 mg/kg/103W- intermittent | Liver: Tumors Tumorigenic: Active as anti-cancer agent | NTIS** PB90-260027 |
| inhalation/mouse | lowest published toxic concentration: 309 mg/kg/103W- intermittent | Brain and Coverings: Tumors Tumorigenic: Active as anti-cancer agent | NTIS** PB90-260027 |
| inhalation/rat | lowest published toxic concentration: 400 ppm/7H/10W- intermittent | Lung, Thorax, or Respiration: Emphysema Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AMIHAB 14,250,1956 |
| inhalation/rat | lowest published toxic concentration: 200 ppm/6H/14D- intermittent | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Other changes | NTPTR* NTP-TR-376,1990 |
| intramuscular/rat | lowest published toxic dose: 400 mg/kg/8D- intermittent | Blood: Changes in bone marrow not included in above Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AEHLAU 2,50,1961 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 1 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | MUREAV 678,76,2009 | |
| TOXICOLOGY REVIEW | MUREAV 769,34,2014 | |
| TOXICOLOGY REVIEW | TOLED5 204,148,2011 | |
| TOXICOLOGY REVIEW | FCTOD7 55,596,2013 | |
| TOXICOLOGY REVIEW | MUREAV 802,1,2016 | |
| TOXICOLOGY REVIEW | MUTAEX 31,347,2016 | |
| TOXICOLOGY REVIEW | RTOPDW 55,43,2009 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 5 ppm (22 mg/m3) | DTLWS* 3,9,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 5 ppm (23 mg/m3), short term exposure limit 10 ppm (47 mg/m3), JUL2008 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 5 ppm (23 mg/m3), short term exposure limit 10 ppm (48 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | ceiling concentration 5 ppm (22 mg/m3), skin, carc, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 1 ppm, short term exposure limit 5 ppm, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 5 ppm (22 mg/m3), Skin, C3 Carcinogen, FEB2006 | |
| Occupational Exposure Limit-ICELAND | short term exposure limit 5 ppm (22 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 5 ppm (22 mg/m3), short term exposure limit 10 ppm (44 mg/m3), skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 5 ppm (22 mg/m3);short term exposure limit 10 ppm (44 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 ppm (23 mg/m3); short term exposure limit 10 ppm (47 mg/m3), JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 1 ppm (4,7 mg/m3), JUL2005 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 3 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 5 ppm (22 mg/m3), carc 2, skin, sen, JAN2011 | |
| Occupational Exposure Limit-THAILAND | time-weighted average 10 ppm (45 mg/m3), JAN1993 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.5 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 10 ppm (45 mg/m3), JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 10 ppm (45 mg/m3), JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | ceiling concentration 10 ppm (45 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | ceiling concentration 10 ppm (45 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | ceiling concentration 10 ppm (45 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | ceiling concentration 10 ppm (45 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ALLYL GLYCIDYL ETHER-air | 10H time-weighted average 5 ppm;short term exposure limit 10 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 04530; Number of Industries 6; Total Number of Facilities 23; Number of Occupations 11; Total Number of Employees Exposed 2457; Total Number of Female Employees Exposed 29 | |
| National Occupational Hazard Survey 1974 | Hazard Code 04530; Number of Industries 9; Total Number of Facilities 153; Number of Occupations 24; Total Number of Employees Exposed 2769 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Studies (inhal);equivocal evidence:mouse,rat | |
| NIOSH Analytical Method, 1994: Allyl glycidyl ether, 2545 | |
| NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978 | |
| NTP Carcinogenesis Studies (inhalation);some evidence:mouse NTPTR* NTP-TR-376,1990 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health