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Registry of Toxic Effects of Chemical Substances (RTECS)

Methane, trichlorofluoro-

RTECS #

PB6125000

CAS #

75-69-4; 83589-40-6

Updated

September 2013

Molecular Weight

137.36

Molecular Formula

CCl3F

Synonyms

Algofrene type 1
Arcton 9
Electro-CF 11
Eskimon 11
F 11
FC 11
Fluorocarbon No. 11
Fluorotrichloromethane
Fluorotrichloromethane (OSHA)
Fluorotrojchlorometan (Polish)
Freon 11
Freon 11A
Freon 11B
Freon HE
Freon MF
Frigen 11
Genetron 11
Halocarbon 11
Isceon 131
Isotron 11
Ledon 11
Methane, fluorotrichloro-
Monofluorotrichloromethane
NCI-C04637
Refrigerant 11
Trichlorofluoromethane (ACGIH:OSHA)
Trichloromonofluoromethane
Ucon flurocarbon 11
Ucon refrigerant 11

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 16 pph/10MCardiac: Change in rateAEHLAU 30,353,1975
inhalation/Dog lowest published toxic concentration: 868500 mg/m3/10MCardiac: Change in rateVCVGH* -,616,1990
inhalation/Dog Lowest published lethal concentration: 22 pph/10MCardiac: Pulse rate decreased with fall in BP

Cardiac: Change in conduction velocity
AEHLAU 30,353,1975
inhalation/guinea pig lowest published toxic concentration: 145000 mg/m3/2HBehavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea
VCVGH* -,616,1990
inhalation/guinea pig lethal concentration (50 percent kill): 25 pph/30MEJTXAZ 9,385,1976
inhalation/human lowest published toxic concentration: 50000 ppm/30MEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Fibrosing alveolitis

Liver: Other changes
EJTXAZ 9,385,1976
inhalation/mouse lethal concentration (50 percent kill): 10 pph/30MEJTXAZ 9,385,1976
inhalation/mouse lowest published toxic concentration: 100 pph/10MCardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate decreased with fall in BP
JAMAAP 214,81,1970
inhalation/mouse Lowest published lethal concentration: 346700 mg/m3/2HVCVGH* -,616,1990
inhalation/rabbit lowest published toxic concentration: 289500 mg/m3/2MCardiac: Cardiac output

Vascular: BP lowering not characterized in autonomic section
VCVGH* -,616,1990
inhalation/rabbit lethal concentration (50 percent kill): 25 pph/30MEJTXAZ 9,385,1976
inhalation/rat lethal concentration (50 percent kill): 13 pph/15MBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
HUTODJ 1,239,1982
inhalation/rat lowest published toxic concentration: 520000 mg/m3/30MBehavioral: General anestheticVCVGH* -,616,1990
inhalation/rat Lowest published lethal concentration: 579000 mg/m3/20MVCVGH* -,616,1990
inhalation/rat Lowest published lethal concentration: 868000 mg/m3/4MVCVGH* -,616,1990
intraperitoneal/mouse lethal dose (50 percent kill): 1743 mg/kgBehavioral: Convulsions or effect on seizure thresholdTOIZAG 18,363,1971
oral/rat Lethal dose: >352 mg/kgNTIS** OTS0520424
oral/rat lowest published toxic dose: 1.25 mL/kgGastrointestinal: Ulceration or bleeding from stomach

Blood: Hemorrhage
JTCTDW 46,325,2008

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 12000 ppm/4H/10D- intermittentBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion
NTIS** OTS0571425

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 1000 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFAZMAE 18,365,1974
TOXICOLOGY REVIEWTXCYAC 3,311,1975
TOXICOLOGY REVIEWNYSJAM 74,1939,1974
TOXICOLOGY REVIEWAIHAAP 29,517,1968
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWHUTOX* -,577,1996

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,312,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1000 ppm (5600 mg/m3)DTLVS* 3,118,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAceiling concentration 1000 ppm (5620 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1000 ppm (5600 mg/m3);KZW 2000 ppm (11200 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1000 ppm (5702 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 500 ppm (2810 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1000 ppm (5600 mg/m3), short term exposure limit 1300 ppm (7000 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVLE 1000 ppm (5600 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 1000 ppm (5700 mg/m3), 2011
Occupational Exposure Limit-HUNGARYProhibited in Hungary, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 500 ppm (2810 mg/m3), NOV2011
Occupational Exposure Limit-JAPANceiling concentration 1000 ppm (5600 mg/m3), MAY2012
Occupational Exposure Limit-KOREAceiling concentration 1,000 ppm (5,600 mg/m3), 2006
Occupational Exposure Limit-MEXICOpeak 1000 ppm (5600 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDceiling concentration 1000 ppm (5620 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 500 ppm (2800 mg/m3), JAN1999
Occupational Exposure Limit-PERUshort term exposure limit 1000 ppm (5619 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 500 mg/m3, MAC(C) 5600 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 1000 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 500 ppm (3000 mg/m3);short term exposure limit 750 ppm (4500 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1000 ppm (5600 mg/m3), JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1000 ppm (5600 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1000 ppm (5600 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1000 ppm (5600 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1000 ppm (5600 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1000 ppm (5600 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1000 ppm (5600 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUOROTRICHLOROMETHANE-airceiling concentration 1000 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 33565; Number of Industries 142; Total Number of Facilities 15107; Number of Occupations 119; Total Number of Employees Exposed 267742; Total Number of Female Employees Exposed 95886
National Occupational Hazard Survey 1974Hazard Code 33565; Number of Industries 304; Total Number of Facilities 68187; Number of Occupations 173; Total Number of Employees Exposed 785337

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (gavage);inadequate studies:ratNCITR* NCI-TR-106,1978
NCI Carcinogenesis Bioassay (gavage);no evidence:mouseNCITR* NCI-TR-106,1978
NIOSH Analytical Method, 1994: Fluorotrichloromethane, 1006
NIOSH Analytical Method, 1994: Trichlorofluoromethane, 1006
On EPA IRIS database
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