Methane, diazo-
RTECS #
PA7000000
CAS #
Updated
September 2013
Molecular Weight
42.05
Molecular Formula
CH2N2
Synonyms
Azimethylene
Diazirine
Diazomethane
Diazomethane (ACGIH:OSHA)
Diazonium methylide
Diazirine
Diazomethane
Diazomethane (ACGIH:OSHA)
Diazonium methylide
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| mutation in microorganisms | /Neurospora crassa | 250 mmol/L (-enzymatic activation step) | HEREAY 35,521,1949 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 272 mg/m3/26W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | BJCAAI 16,92,1962 |
| inhalation/rat | lowest published toxic concentration: 272 mg/m3/26W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | BJCAAI 16,92,1962 |
| subcutaneous/mouse | lowest published toxic dose: 48 gm/kg/52W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | BJCAAI 16,92,1962 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/cat | lethal concentration (50 percent kill): 175 ppm/10M | 85JCAE -,496,1986 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.2 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Suspected human carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMEMDT 7,223,1974 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 7,223,1974 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMSUDL 7,56,1987 |
| TOXICOLOGY REVIEW | CHHSA* 9,6,2002 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.2 ppm (0.4 mg/m3) | DTLWS* 3,15,1973 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.2 ppm (0.34 mg/m3), Carcinogen, JUL2008 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.2 ppm (0.34 mg/m3), Carcinogen, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.2 ppm (0.4 mg/m3), carc, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.2 ppm (0.35 mg/m3), short term exposure limit 0.6 ppm (1 mg/m3), NOV2011 | |
| Occupational Exposure Limit-HUNGARY | ceiling concentration 0.01 mg/m3, Carcinogen, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.2 ppm (0.4 mg/m3), carc, NOV2011 | |
| Occupational Exposure Limit-INDIA | short term exposure limit 0.4 mg/m3, Skin, JAN1993 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.2 ppm (0.4 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.2 ppm (0.4 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.2 ppm (0.34 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.2 ppm (0.4 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0.2 ppm (0.34 mg/m3), JUL2005 | |
| Occupational Exposure Limit-RUSSIA | time-weighted average 0.2 ppm (0.4 mg/m3), JUN2003 | |
| Occupational Exposure Limit-SWEDEN | Group B Carcinogen, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.2 ppm (0.35 mg/m3), carc 2, JAN2011 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.2 ppm (0.4 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.2 ppm (0.4 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.2 ppm (0.4 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.2 ppm (0.4 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIAZOMETHANE-air | 10H time-weighted average 0.2 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Hazard Survey 1974 | Hazard Code 23370; Number of Industries 1; Total Number of Facilities 18; Number of Occupations 2; Total Number of Employees Exposed 234 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health