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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethylamine, 2,2'-oxybis(N,N-dimethyl-

RTECS #

KR9460000

CAS #

3033-62-3

Updated

September 2013

Molecular Weight

160.30

Molecular Formula

C8H20N2O

Synonyms

2,2'-Oxybis(N,N-dimethylethylamine)
A 99 (Amine)
Bis(2-dimethylaminoethyl)ether
Dabco BL 11
Dabco BL 19
Dabco BL 19I
Kalpur PC
Niax A 1
Niax A 99
Texacat ZF 20
Toyocat ET
Toyocat ETS

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 1 mg severeUCDS** 12/27/1971
eye /rabbit 250 µg/24H severe85JCAE -,721,1986
skin /rabbit 10%JAPTO* 25,260,2005
skin /rabbit 5 mg/24H severe85JCAE -,721,1986
skin /rabbit 500 mg open irritation test severeUCDS** 12/27/1971
skin /rabbit 100 mg/24H severeJTOTDO 5,3,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sister chromatid exchangeovary/hamster0.005 pph (-enzymatic activation step)JAPTO* 25,260,2005

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
skin/rabbit 650 mg/kg (6-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JTOTDO 5,263,1986
skin/rabbit 700 µg/kg (6-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)JAPTO* 25,260,2005

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 117 ppm/6HEye: Corneal damage

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes
NTIS** OTS0536387
inhalation/rat lethal concentration (50 percent kill): 166 ppm/6HBehavioral: Somnolence (general depressed activity)JAPTO* 25,260,2005
inhalation/rat lowest published toxic concentration: 68 ppm/6HEye: Conjunctiva irritationJAPTO* 25,260,2005
inhalation/rat Lowest published lethal concentration: 149 ppm/6HOlfaction: Other olfaction effects

Eye: Corneal damage

Lung, Thorax, or Respiration: Respiratory depression
JAPTO* 25,260,2005
inhalation/rat Lowest published lethal concentration: 149 ppm/6HLung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 25,260,2005
intraperitoneal/mouse lethal dose (50 percent kill): 171 mg/kgJAPTO* 25,260,2005
intraperitoneal/mouse lethal dose (50 percent kill): 128 mg/kgBehavioral: SleepJAPTO* 25,260,2005
intravenous/rabbit lethal dose (50 percent kill): 183 mg/kgJAPTO* 25,260,2005
intravenous/rat lethal dose (50 percent kill): 286 mg/kgJAPTO* 25,260,2005
ocular/rabbit lowest published toxic concentration: 10 pphEye: Corneal damageJAPTO* 25,260,2005
ocular/rabbit lowest published toxic concentration: 1 pphEye: Other eye effectsJAPTO* 25,260,2005
ocular/rabbit lowest published toxic concentration: 4.6 ppm/2HEye: Conjunctiva irritation

Eye: Corneal damage
JAPTO* 25,260,2005
oral/rat lethal dose (50 percent kill): 571 mg/kgNTIS** OTS0545161
oral/rat lethal dose (50 percent kill): 1045 mg/kgBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes
JAPTO* 25,260,2005
oral/rat lethal dose (50 percent kill): 1045 mg/kgGastrointestinal: Other changes

Liver: Other changes

Blood: Hemorrhage
JAPTO* 25,260,2005
oral/rat lethal dose (50 percent kill): 1045 mg/kgNutritional and Gross Metabolic: Weight loss or decreased weight gainJAPTO* 25,260,2005
skin/rabbit lethal dose (50 percent kill): 348 mg/kg/4HBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Gastrointestinal: Changes in structure or function of salivary glands
JAPTO* 25,260,2005
skin/rabbit lethal dose (50 percent kill): 314 mg/kg/24HBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Gastrointestinal: Changes in structure or function of salivary glands
JAPTO* 25,260,2005
skin/rabbit lethal dose (50 percent kill): 280 µL/kgAIHAAP 30,470,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 20 ppm/6H/9D- intermittentOlfaction: Other olfaction effects

Eye: Ptosis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0536526
inhalation/rat lowest published toxic concentration: 47 ppm/5D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJAPTO* 25,260,2005
inhalation/rat lowest published toxic concentration: 90 ppm/3D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJAPTO* 25,260,2005
inhalation/rat lowest published toxic concentration: 22 ppm/11D- intermittentOlfaction: Other olfaction effects

Eye: Conjunctiva irritation

Endocrine: Hyperglycemia
JAPTO* 25,260,2005
inhalation/rat lowest published toxic concentration: 22 ppm/11D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 25,260,2005
inhalation/rat lowest published toxic concentration: 22 ppm/11D- intermittentNutritional and Gross Metabolic: Dehydration

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JAPTO* 25,260,2005
inhalation/rat lowest published toxic concentration: 47 ppm/11D- intermittentCardiac: Changes in coronary arteries

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
JAPTO* 25,260,2005
inhalation/rat lowest published toxic concentration: 47 ppm/11D- intermittentBlood: Changes in spleenJAPTO* 25,260,2005
inhalation/rat lowest published toxic concentration: 5.8 ppm/14W- intermittentOlfaction: Other olfaction effects

Eye: Conjunctiva irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 25,260,2005
inhalation/rat lowest published toxic concentration: 1.25 ppm/13W- intermittentEye: Corneal damageJAPTO* 25,260,2005
intraperitoneal/mouse lowest published toxic dose: 0.14 mg/kg/14D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJAPTO* 25,260,2005
intraperitoneal/rat lowest published toxic dose: 0.14 mg/kg/14D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJAPTO* 25,260,2005
oral/rat lowest published toxic dose: 1540 mg/kg/7D- intermittentKidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0536157
skin/rabbit lowest published toxic dose: 292 mg/kg/11D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTOTDO 5,3,1986
skin/rabbit lowest published toxic dose: 391 mg/kg/13W- intermittentSkin: After systemic exposure: Dermatitis, otherJTOTDO 5,3,1986
skin/rabbit lowest published toxic dose: 0.225 mg/kg/11D- intermittentSkin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 25,260,2005
skin/rabbit lowest published toxic dose: 0.225 mg/kg/11D- intermittentSkin: After topical application: Primary irritation

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight
JAPTO* 25,260,2005
skin/rabbit lowest published toxic dose: 0.45 mg/kg/11D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJAPTO* 25,260,2005
skin/rabbit lowest published toxic dose: 0.45 mg/kg/11D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight
JAPTO* 25,260,2005
skin/rabbit lowest published toxic dose: 0.26 mg/kg/13W- intermittentSkin: After topical application: Primary irritationJAPTO* 25,260,2005
skin/rabbit lowest published toxic dose: 0.7 mg/kg/14D- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 25,260,2005
skin/rabbit lowest published toxic dose: 0.35 mg/kg/14D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Skin: After topical application: Primary irritation
JAPTO* 25,260,2005

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 ppm;short term exposure limit 0.15 ppm (skin)DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 0.05 ppm (0.33 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 0.15 ppm (1 mg/m3), Skin, MAR2002

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BIS(2-(DIMETHYlAMINO)ETHYL)ETHER-airminimize exposureNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code T0015; Number of Industries 2; Total Number of Facilities 60; Number of Occupations 5; Total Number of Employees Exposed 1529; Total Number of Female Employees Exposed 165
National Occupational Hazard Survey 1974Hazard Code T0015; Number of Industries 1; Total Number of Facilities 8; Number of Occupations 2; Total Number of Employees Exposed 40

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 26, 1978
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