p-Anisidine
RTECS #
BZ5450000
CAS #
Updated
June 2018
Molecular Weight
123.17
Molecular Formula
C7H9NO
Synonyms
1-Amino-4-methoxybenzene
4-Aminoanisole
4-Anisidine
4-Methoxy-1-aminobenzene
4-Methoxyaniline
4-Methoxybenzenamine
4-Methoxybenzeneamine
Aniline, p-methoxy-
Anisole, p-amino-
Benzenamine, 4-methoxy- (9CI)
p-Aminoanisole
p-Anisidine (ACGIH:OSHA)
p-Anisylamine
p-Methoxyaniline
p-Methoxyphenylamine
4-Aminoanisole
4-Anisidine
4-Methoxy-1-aminobenzene
4-Methoxyaniline
4-Methoxybenzenamine
4-Methoxybenzeneamine
Aniline, p-methoxy-
Anisole, p-amino-
Benzenamine, 4-methoxy- (9CI)
p-Aminoanisole
p-Anisidine (ACGIH:OSHA)
p-Anisylamine
p-Methoxyaniline
p-Methoxyphenylamine
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | ovary/hamster | 160 mg/L | EMMUEG 10(Suppl 10),1,1987 |
| DNA Damage | lymphocyte/mouse | 202 µmol/L | MUREAV 203,155,1988 |
| DNA Damage | other cell types/mouse | 32 mg/L/24H (-enzymatic activation step) | MUREAV 541,9,2003 |
| DNA inhibition | oral/mouse | 200 mg/kg | MUREAV 46,305,1977 |
| DNA repair | /Escherichia coli | 39 mmol/L | MUREAV 272,145,1992 |
| host-mediated assay | Escherichia coli/mouse | 780 mg/kg | MUREAV 272,161,1992 |
| morphological transform | embryo/hamster | 6.16 mg/L/7D | MUTAEX 20,51,2005 |
| mutation in mammalian somatic cells | lymphocyte/mouse | 392 µmol/L | MUTAEX 3,193,1988 |
| mutation in microorganisms | lymphocyte/mouse | 196 µmol/L (+enzymatic activation step) | MUTAEX 3,193,1988 |
| mutation in microorganisms | /Salmonella typhimurium | 1 mg/plate (-enzymatic activation step) | ENMUDM 5(Suppl 1),3,1983 |
| sister chromatid exchange | ovary/hamster | 14 mg/L | EMMUEG 10(Suppl 10),1,1987 |
| specific locus test | Ascites tumor/mouse | 32 mg/L/24H | EMMUEG 42,91,2003 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 16.4 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 40,153,2017 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 806 mg/kg | JMCMAR 17,900,1974 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 1400 mg/kg | AGGHAR 15,447,1957 | |
| ocular/rabbit | lowest published toxic dose: 100 pph | Eye: Conjunctiva irritation | TPKVAL 4,91,1962 |
| oral/mouse | lowest published lethal dose: 295.6 mg/kg | Cardiac: Other changes Liver: Fatty liver degeneration Liver: Other changes | TPKVAL 4,91,1962 |
| oral/mouse | lethal dose (50 percent kill): 1410 mg/kg | Eye: Other eye effects Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Ataxia | ATDAEI 1,184,1992 |
| oral/rabbit | lethal dose (50 percent kill): 2900 mg/kg | Kidney, Ureter, and Bladder: Other changes Blood: Normocytic anemia Blood: Other changes | IMEMDT 27,63,1982 |
| oral/rat | lethal dose (50 percent kill): 1320 mg/kg | TLSMA6 128,14,1979 | |
| skin/rat | lethal dose (50 percent kill): 3200 mg/kg | AGGHAR 15,447,1957 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 10 mg/m3/4H/30D- intermittent | Brain and Coverings: Changes in circulation Peripheral Nerve and Sensation: Recording from peripheral motor nerve Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | TPKVAL 4,91,1962 |
| inhalation/rat | lowest published toxic concentration: 10 mg/m3/4H/244D- intermittent | Blood: Normocytic anemia | TPKVAL 4,91,1962 |
| inhalation/rat | lowest published toxic concentration: 10 mg/m3/4H/335D- intermittent | Blood: Changes in other cell count (unspecified) | TPKVAL 4,91,1962 |
| inhalation/rat | lowest published toxic concentration: 10 mg/m3/4H/0.5Y- intermittent | Gastrointestinal: Ulceration or bleeding from small intestine Endocrine: Changes in spleen weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 4,91,1962 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.5 mg/m3 (skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 27,63,1982 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMSUDL 7,56,1987 |
| TOXICOLOGY REVIEW | MUREAV 786-788,14,2015 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.1 ppm (0.5 mg/m3) (skin) | DTLWS* 3,10,1973 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.1 ppm (0.5 mg/m3), JAN1993 | |
| Occupational Exposure Limit-AUSTRIA | TRK-TMW 0.1 ppm (0.5 mg/m3);KZW 0.2 ppm (1 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.1 ppm (0.5 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.1 ppm (0.5 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.1 ppm (0.5 mg/m3), short term exposure limit 0.3 ppm (1.5 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.1 ppm (0.5 mg/m3), Skin, FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.1 ppm (0.5 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-INDIA | time-weighted average 0.1 ppm (0.5 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 0.1 ppm (0.5 mg/m3), skin, MAY2012 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.1 ppm (0.5 mg/m3) (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.1 ppm (0.5 mg/m3), skin, JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 0.1 ppm (0.5 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 1 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.5 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.5 mg/m3, Skin, JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-ANISIDINE-air | 10H time-weighted average 0.5 mg/m3 (Sk) | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NIOSH Analytical Method, 1994: Anisidine, 2514 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health