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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, fluoro-, sodium salt

RTECS #

AH9100000

CAS #

62-74-8

Updated

September 2013

Molecular Weight

100.03

Molecular Formula

C2H2FO2·Na

Synonyms

Compound 1080
Compound No. 1080
Fluorakil 3
Fluoressigaeure (German)
Fluoroacetic acid, sodium salt
Fluoroctan sodny (Czech)
Fratol
Furatol
Latka 1080 (Czech)
Monofluoressigsaures natrium (German)
Natriumfluoracetaat (Dutch)
Natriumfluoracetat (German)
Ratbane 1080
RCRA waste number P058
Sodio, fluoracetato di (Italian)
Sodium fluoacetate
Sodium fluoacetic acid
Sodium fluoracetate
Sodium fluoroacetate
Sodium fluoroacetate (ACGIH:OSHA)
Sodium fluoroacetate de (French)
Sodium monofluoroacetate
TL 869
Yasoknock

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
host-mediated assayother cell types/mouse5 mg/kgFOBLAN 21,244,1975

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 27500 µg/kg (11D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductEXPEAM 21,446,1965
oral/rat 210 µg/kg (3D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductJRPFA4 56,201,1979

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intramuscular/domestic animal lethal dose (50 percent kill): 700 µg/kgAJPEAG 36,1427,1946
intraperitoneal/cat lethal dose (50 percent kill): 300 µg/kgAJPEAG 36,1427,1946
intraperitoneal/domestic animal lethal dose (50 percent kill): 200 µg/kgAJPEAG 36,1427,1946
intraperitoneal/guinea pig lethal dose (50 percent kill): 378 µg/kgJPETAB 95,62,1949
intraperitoneal/mammal (species unspecified) lethal dose (50 percent kill): 100 µg/kgBehavioral: Convulsions or effect on seizure thresholdJAPMA8 36,59,1947
intraperitoneal/mouse lethal dose (50 percent kill): 7 mg/kgNEZAAQ 34,193,1979
intraperitoneal/pig lethal dose (50 percent kill): 300 µg/kgAJPEAG 36,1427,1946
intraperitoneal/rat lethal dose (50 percent kill): 1940 µg/kgBJEPA5 50,277,1969
intraperitoneal/squirrel lethal dose (50 percent kill): 400 µg/kgBehavioral: Somnolence (general depressed activity)JAPMA8 36,59,1947
intraperitoneal/wild bird lethal dose (50 percent kill): 102 mg/kgAWLRAO 15,239,1988
intravenous/Dog lethal dose (50 percent kill): 60 µg/kgYKYUA6 31,1385,1980
intravenous/domestic animal lowest published lethal dose: 519 µg/kgLiver: Other changes

Endocrine: Hyperglycemia

Musculoskeletal: Other changes
JCPTA9 70,145,1960
intravenous/monkey lethal dose (50 percent kill): 5 mg/kgAJPEAG 36,1427,1946
intravenous/rabbit lethal dose (50 percent kill): 300 µg/kgAJPEAG 36,1427,1946
oral/cat lethal dose (50 percent kill): 350 µg/kgJAPMA8 37,307,1948
oral/chicken lowest published lethal dose: 5900 µg/kgJAPMA8 36,59,1947
oral/Dog lethal dose (50 percent kill): 66 µg/kgJPETAB 101,82,1951
oral/domestic animal lethal dose (50 percent kill): 500 µg/kgCardiac: Other changesAWLRAO 9,487,1982
oral/duck lethal dose (50 percent kill): 4810 µg/kgTXAPA9 22,556,1972
oral/frog lowest published lethal dose: 54 mg/kgVHTODE 15,6,1973
oral/guinea pig lethal dose (50 percent kill): 300 µg/kgAJPEAG 36,1427,1946
oral/human lowest published lethal dose: 714 µg/kgENTOX* ,62,2005
oral/mammal (species unspecified) lethal dose (50 percent kill): 110 µg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
AWLRAO 8,385,1981
oral/monkey lethal dose (50 percent kill): 300 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
NYKZAU 65,182,1969
oral/mouse lethal dose (50 percent kill): 100 µg/kgYKYUA6 28,329,1977
oral/pigeon lethal dose (50 percent kill): 2 mg/kgJAPMA8 36,59,1947
oral/quail lethal dose (50 percent kill): 18 mg/kgTXAPA9 20,57,1971
oral/rabbit lethal dose (50 percent kill): 340 µg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
AWLRAO 9,487,1982
oral/rat lethal dose (50 percent kill): 100 µg/kgAJPEAG 36,1427,1946
oral/squirrel lethal dose (50 percent kill): 300 µg/kgAJPEAG 36,1427,1946
oral/wild bird lethal dose (50 percent kill): 2370 µg/kgAECTCV 12,355,1983
skin/guinea pig lethal dose (50 percent kill): 1600 µg/kgCardiac: Other changes

Lung, Thorax, or Respiration: Dyspnea
NYKZAU 65,182,1969
skin/mouse lethal dose (50 percent kill): 25300 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
NYKZAU 65,182,1969
skin/rat lethal dose (50 percent kill): 48 mg/kgNYKZAU 65,182,1969
subcutaneous/frog lethal dose (50 percent kill): 1 gm/kgAJPEAG 36,1427,1946
subcutaneous/guinea pig lethal dose (50 percent kill): 250 µg/kgBCPCA6 6,169,1961
subcutaneous/mouse lethal dose (50 percent kill): 7200 µg/kgNDRC** 30101,2,1945
subcutaneous/rabbit lethal dose (50 percent kill): 281 µg/kgJPETAB 95,62,1949
subcutaneous/wild bird lethal dose (50 percent kill): 630 µg/kgEye: Ptosis

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
AWLRAO 11,373,1984
unreported route/horse, donkey lethal dose (50 percent kill): 1 mg/kgAJPEAG 36,1427,1946
unreported route/man lowest published lethal dose: 5 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes
AJPEAG 36,1427,1946
unreported route/mouse lethal dose (50 percent kill): 10 mg/kgYKYUA6 30,397,1979
unreported route/rat lethal dose (50 percent kill): 15 mg/kgYKYUA6 30,397,1979

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 6 mg/kg/3D- intermittentBlood: Change in clotting factors

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JEMAAJ 45,694,1962
intravenous/domestic animal lowest published toxic dose: 519 µg/kg/3D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJCPTA9 70,145,1960
oral/chicken lowest published toxic dose: 20 mg/kg/3D- intermittentCardiac: Other changes

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAVMA4 111,301,1947
oral/Dog lowest published toxic dose: 0.15 mg/kg/5D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
JTSCDR 29,155,2004
oral/Dog lowest published toxic dose: 0.69 mg/kg/23D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJTSCDR 29,155,2004
oral/Dog lowest published toxic dose: 2.73 mg/kg/91D- intermittentBrain and Coverings: Other degenerative changesJTSCDR 29,155,2004
oral/domestic animal lowest published toxic dose: 649 µg/kg/30D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJCPTA9 70,145,1960
oral/mammal (species unspecified) lowest published toxic dose: 686 mg/kg/28D- continuousCardiac: Changes in heart weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
ETOCDK 5,213,1986
oral/mammal (species unspecified) lowest published toxic dose: 8500 µg/kg/28D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in spleen weight
TOXID9 3,147,1983
oral/mouse lowest published toxic dose: 51 mg/kg/30D- intermittentBehavioral: Food intake (animal)

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Alteration in gastric secretion
NHOZAX 26,203,1972
oral/rat lowest published toxic dose: 19.25 mg/kg/77D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOSCF2 69,439,2002
oral/rat lowest published toxic dose: 22.5 mg/kg/90D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Cardiac: Cardiomyopathy including infarction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 69,439,2002

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 mg/m3 (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWIMSUAI 21,440,1952
TOXICOLOGY REVIEWAMSSAQ 400,5,1963
TOXICOLOGY REVIEWIMSUAI 19,535,1950
TOXICOLOGY REVIEWEMCPT* 2,89,2005
TOXICOLOGY REVIEWAEMED3 45,609,2005
TOXICOLOGY REVIEWJJATDK 26,148,2006
TOXICOLOGY REVIEWENTOX* -,62,2005
TOXICOLOGY REVIEWHUTOX* -,561,1996
TOXICOLOGY REVIEWJFSCAS (5),76,1965
TOXICOLOGY REVIEWNBREV* 5,1,1981

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,255,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.05 mg/m3 (skin)DTLVS* 3,232,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.05 mg/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 mg/m3, short term exposure limit 0.15 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.05 mg/m3;KZW 0.2 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.05 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.05 mg/m3, skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.05 mg/m3, short term exposure limit 0.15 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.05 mg/m3, Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.05 mg/m3, inhal, skin, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.05 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.05 mg/m3, short term exposure limit 0.15 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.05 mg/m3;short term exposure limit 0.15 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.05 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,05 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 mg/m3, KZG-week 0.1 mg/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.05 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.05 mg/m3, Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.05 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.05 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.05 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.05 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.05 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-airtime-weighted average 0.05 mg/m3;short term exposure limit 0.15 mg/m3 (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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