CDC Study Shows Flu Vaccination Prevents Severe Flu Illness in U.S. Children

Vaccine protects, even when vaccine virus and circulating viruses are different

Press Release

For Immediate Release: Thursday, January 13, 2022
Contact: Media Relations
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A new CDC study published in the journal Clinical Infectious Diseases (CID) shows that flu vaccination protected children against serious flu illness even when they were infected with a flu virus that was antigenically different from the vaccine virus. This reinforces the benefit of flu vaccination, even when circulating flu viruses have drifted and are different from the virus used in vaccine production.

“This study highlights that flu can cause serious illness in children, but flu vaccines can be lifesaving.  This is very good news” said CDC Director Rochelle P. Walensky, M.D., M.P.H. “It’s especially important that children get a flu vaccine in addition to their recommended COVID-19 vaccines this season. Flu season has started and currently flu vaccination is down in children, so now is the best time to get your child vaccinated, if you have not already.”

A hallmark of flu viruses is that they are constantly changing through a process called antigenic drift, especially H3N2 viruses, which are often associated with more severe flu seasons. How well flu vaccines work is determined in part by the similarity between the viruses chosen for vaccine production and viruses circulating in populations. While the composition of flu vaccines is reviewed annually and updated to match evolving viruses, even then, changes in the virus can outpace vaccine production.

The CDC study reports that flu vaccination reduced the risk of severe flu in children by 78% against similar flu A viruses and 47% against flu A viruses that had drifted from the vaccine virus. Further, the vaccine was 76% effective at preventing life-threatening influenza, which included invasive mechanical ventilation, CPR, and other severe complications including death. This study adds to evidence showing that some people who are vaccinated still get sick, but the vaccination can decrease illness severity.

This large CDC study summarizes findings from a CDC vaccine effectiveness network that looks at how well flu vaccines work at preventing serious flu illness in children. This network is now called the Overcoming COVID-19 Network and will investigate how well COVID-19 vaccines work to prevent COVID-19 hospitalizations in children in addition to how well flu vaccines protect children against flu hospitalization during 2022.

Researchers looked at data from the 2019–2020 flu season, during which a record-breaking 199 flu deaths in children were reported to CDC and when most flu activity was caused by two viruses that were antigenically different from their corresponding vaccine viruses.

According to CDC flu surveillance systems, flu season has started in many parts of the country with continued flu activity expected over the coming weeks. Most flu detected so far has been H3N2 flu found in children and young adults. These circulating H3N2 flu viruses are genetically closely related to the H3N2 vaccine virus, but have some differences that may result in reduced protection against those viruses from the vaccine. As this study highlights, however, vaccination can still have important benefits even when this happens. It is also important to note that usually many flu viruses spread over any one season and flu vaccines protect against four different viruses.

Flu illness can be dangerous for children. Each year, millions of children get sick with seasonal flu, thousands of children are hospitalized, and some children die from flu. Two flu deaths in children have been reported to CDC already this season. Flu can be especially dangerous for children younger than 5 years old because they are at higher risk of getting very sick from flu because of their age.

With flu activity just getting started, that means there’s still time to benefit from flu vaccination this season. It takes about two weeks after vaccination for antibodies to develop in the body and provide protection against influenza virus infection. The U.S. Advisory Committee on Immunization Practices (ACIP) has recommended annual vaccination for all persons aged 6 months or older since 2010. Despite this recommendation, during the 2020–2021 flu season U.S. flu vaccination coverage remained between 50.8%–68% for children younger than 18 years old.


CDC works 24/7 protecting America’s health, safety and security. Whether disease start at home or abroad, are curable or preventable, chronic or acute, or from human activity or deliberate attack, CDC responds to America’s most pressing health threats. CDC is headquartered in Atlanta and has experts located throughout the United States and the world.