One & Only Campaign

One Needle, One Syringe, Only One Time. Safe Injection Practices Coalition.

The One & Only Campaign is a public health effort to eliminate unsafe medical injections.

Led by CDC and the Safe Injection Practices Coalition (SIPC), the campaign seeks to raise awareness among patients and healthcare providers about safe injection practices, which are critical to the overall safety of healthcare delivery.

Unsafe injection practices put patients and healthcare personnel at risk of disease transmission, including bacterial infections like MRSA or bloodborne pathogens like hepatitis C virus.

Did you know…

Every year, unsafe injection practices by US healthcare providers—like syringe reuse and misuse of medications vials— cause outbreaks.

Since 2001, discovery of unsafe injection practices, have prompted nearly 200,000 patients to seek testing for bloodborne pathogens.

Prevent disease transmission from unsafe injection practices.

The campaign’s goal is to make sure that patients are protected each time they receive an injectable medication. Through targeted education and awareness efforts, the campaign empowers patients and healthcare providers to insist on nothing less than safe injections—every time, for every patient.

Safe injection practices are part of Standard Precautions A good rule to remember is One Needle, One Syringe, Only One Time.

Campaign Resources


SIPC created these educational resources to remind healthcare providers—across all settings and specialties—about the basics of injection safety. It is the responsibility of every provider who prepares and administers injections, or supervises those that prepare and administer injections, to make sure that patients are not exposed to life-threatening infections.

  • Use these resources in staff training and auditing.
  • Discuss them in presentations.
  • Post them in public areas.
  • Share them on social media.

These resources can also educate patients. Patients should be encouraged to start a dialogue with their healthcare team and ask questions about safe injection practices.