Notice of Funding Opportunity PS21-2102: Comprehensive High-Impact HIV Prevention Programs for Community Based Organizations

The notice of funding opportunity (NOFO) is available at  To view the entire announcement and learn more about the CDC application process, go to and click on Search Grant Opportunities (Archives). Then, select Search Grant Opportunities and enter the word “HIV Prevention or PS21-2102” in the Key Search field.

Program Announcement PS21-2102 [PDF – 607 KB]

Executive Summary

The Centers for Disease Control and Prevention announces the availability of fiscal year 2021 funds for a cooperative agreement program for community-based organizations (CBOs) to develop and implement high-impact human immunodeficiency virus (HIV) prevention programs.

Community-based organizations are uniquely positioned to complement and extend the reach of HIV prevention efforts implemented by state and local health departments and education agencies to support the optimization of services across public, private, and other community-based organizations to achieve objectives of increased identification of HIV diagnoses, referral for pre-exposure prophylaxis (PrEP) and non-occupational post-exposure prophylaxis (nPEP) services, earlier entry to HIV care, and increased consistency of care.

The comprehensive HIV prevention funded program must align with the pillars of the nation’s Ending the HIV Epidemic Initiative (EHE) – Diagnose, Treat, Prevent, and Respond, and employs CDC’s High-Impact Prevention approach. This includes the implementation and delivery of strategic practices that focus on (1) diagnosis of HIV, (2) treatment of HIV-positive persons, (3) preventing new HIV transmissions, and (4) responding quickly to potential HIV outbreaks to get needed prevention and treatment services to people who need them, in compliance with the requirements of the NOFO. CBOs should assess and consider a combination of approaches that include the required components of the NOFO and additional components that will, when combined, have the greatest public health impact. These combined activities should also have the greatest potential to address the social and structural determinants of health that are known to create the most significant barriers to testing; linkage to, retention in, and re-engagement with care; and prevention support services.


The purpose of this program is to implement comprehensive HIV prevention programs to reduce morbidity, mortality, and related health disparities in accordance with the Ending the HIV Epidemic Initiative: A Plan for America and CDC’s High-Impact HIV Prevention approach. This NOFO focuses on addressing the national HIV epidemic by reducing new infections, increasing access to care, and promoting health equity. The aforementioned will be achieved by enhancing community-based organizations’ capacities to increase HIV testing and referrals to Partner Services, link person with HIV to HIV medical care and ART, provide or refer prevention and essential support services, including SSPs, for persons with HIV and persons at risk for acquiring HIV, and increase program monitoring and accountability.