Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home

Overview of Laboratory Confirmation by IgM Serology

Laboratory confirmation of mumps in previously vaccinated or previously infected individuals is challenging, and failure to detect mumps IgM in previously vaccinated persons has been well documented.

Persons with a history of mumps vaccination may not have detectable mumps IgM antibody regardless of timing of specimen collection.

The ability to detect IgM varies by vaccination status and is highest in unvaccinated persons (80%–100%) (Sakata et al. 1985), intermediate in one-dose vaccine recipients (60%–80%) (Briss et al. 1994; Narita et al. 1998), and lowest in two-dose vaccine recipients (13%–14%) (Bitsko et al. 2008; Rota et al. 2009).

Mumps exposure history IgM IgG Comments References
Unvaccinated; no history of mumps + + or − IgM may be detected for weeks to months; low levels of IgG may be present at symptom onset Meurman et al. 1982; Sakata et al. 1985
1–dose vaccine history + or − Likely + 50% of serum samples collected 1–10 days after symptom onset were IgM-positive; 50%–80% of serum samples collected >10 days after symptom onset were IgM-positive Narita et al. 1998; Jin et al. 2004; Krause et al. 2007
2–dose vaccine history + or − Likely + 13%–15% of serum samples collected 1–3 days after symptom onset were IgM-positive* Bitsko et al. 2008; Rota et al. 2009

*30%–35% of buccal samples collected 1–3 days after symptom onset were positive by real-time RT-PCR among persons with 2 doses of MMR (Bitsko et al. 2008; Rota et al. 2009)

Images and logos on this website which are trademarked/copyrighted or used with permission of the trademark/copyright or logo holder are not in the public domain. These images and logos have been licensed for or used with permission in the materials provided on this website. The materials in the form presented on this website may be used without seeking further permission. Any other use of trademarked/copyrighted images or logos requires permission from the trademark/copyright holder...more

External Web Site Policy This graphic notice means that you are leaving an HHS Web site. For more information, please see the Exit Notification and Disclaimer policy.

Contact Us:
  • Centers for Disease Control and Prevention
    1600 Clifton Rd
    Atlanta, GA 30333
  • 800-CDC-INFO
    TTY: (888) 232-6348
    Contact CDC-INFO The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Road Atlanta, GA 30329-4027, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO
A-Z Index
  1. A
  2. B
  3. C
  4. D
  5. E
  6. F
  7. G
  8. H
  9. I
  10. J
  11. K
  12. L
  13. M
  14. N
  15. O
  16. P
  17. Q
  18. R
  19. S
  20. T
  21. U
  22. V
  23. W
  24. X
  25. Y
  26. Z
  27. #