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Interim Recommendations for Infection Control in Health-Care Facilities Caring for Patients with Known or Suspected Avian Influenza

This website is archived and is no longer being maintained or updated. For updated information on avian influenza, see the CDC Avian Influenza website and the World Health Organization (WHO) Avian Influenza Situation Update page.

Note: CDC is revising its interim guidance for infection control precautions for avian influenza. The revised recommendations will be posted on this website as soon as they are finalized.


This document provides interim guidance for protection of health-care workers involved in the care of patients in the United States with known or suspected avian influenza. Depending upon where avian influenza is active in the world, such patients may be recently returning travelers entering U.S. health-care facilities or individuals who have had close contact with domestic poultry infected with avian influenza in the United States. For information regarding the clinical and epidemiologic criteria to be used in screening patients for possible avian influenza, see the “Update on Influenza A(H5N1) and SARS: Interim Recommendations for Enhanced U.S. Surveillance, Testing, and Infection Control” and “Interim Recommendations for Persons with Possible Exposure to Avian Influenza During Outbreaks Among Poultry in the United States .”


Influenza viruses that infect primarily birds are called “avian influenza viruses.” These type A influenza viruses are genetically distinguishable from influenza viruses that usually infect people. There are many subtypes of avian influenza A viruses, including H7 and H5. Avian influenza viruses can be distinguished as “low pathogenic” and “highly pathogenic” forms based on genetic features of the virus and the severity of the illness they cause in poultry.

Avian influenza viruses do not usually infect humans; however, several instances of human infections and outbreaks of avian influenza have been reported since 1997 (for more information, see “ Basic Information About Avian Influenza” ). In 2003, influenza A (H7N7) infections occurred in the Netherlands among persons who handled infected poultry and among their families during an outbreak of avian flu among poultry. More than 80 cases of H7N7 illness were confirmed by testing (the symptoms were mostly confined to eye infections, with some respiratory symptoms), and one patient died (a veterinarian who had visited an H7N7 influenza-affected farm). Although there was evidence of limited person-to-person spread of infection, sustained human-to-human transmission did not occur in this or other outbreaks of avian influenza. It is believed that most cases of avian influenza infection in humans have resulted from contact with infected poultry or contaminated surfaces. However, other means of transmission are also possible, such as the virus becoming aerosolized and landing on exposed surfaces of the mouth, nose, or eyes, or being inhaled into the lungs.

Infection and disease in people caused by highly pathogenic avian influenza H5N1 infection have been identified recently in Vietnam and Thailand. On February 1, 2004, the World Health Organization (WHO) reported that laboratory test results had confirmed two fatal cases of human H5N1 infection in Vietnam in which human-to-human transmission may have occurred. The cases occurred in two sisters who were part of a cluster of four cases of severe respiratory illness in a single family. According to WHO, a detailed investigation of this cluster concluded that limited human-to-human transmission was one possible explanation, but direct poultry-to-human transmission could not be ruled out.

The following interim recommendations are based on what are deemed optimal precautions for protecting individuals involved in the care of patients with highly pathogenic avian influenza from illness and for reducing the risk of viral reassortment (i.e., mixing of genes from human and avian viruses). The ability of low pathogenic avian influenza viruses to cause infection and serious disease is less well established, but appears to be lower than that of highly pathogenic viruses based on available information. Nonetheless, it is considered prudent to take all possible precautions to the extent feasible when caring for patients with known or possible avian influenza.

Rationale for Enhanced Precautions

Human influenza is thought to transmit primarily via large respiratory droplets. Standard Precautions plus Droplet Precautions are recommended for the care of patients infected with human influenza. However, given the uncertainty about the exact modes by which avian influenza may first transmit between humans additional precautions for health-care workers involved in the care of patients with documented or suspected avian influenza may be prudent. The rationale for the use of additional precautions for avian influenza as compared with human influenza include the following:

Recommendations for Avian Influenza

All patients who present to a health-care setting with fever and respiratory symptoms should be managed according to recommendations for Respiratory Hygiene and Cough Etiquette and questioned regarding their recent travel history.

Patients with a history of travel within 10 days to a country with avian influenza activity and are hospitalized with a severe febrile respiratory illness, or are otherwise under evaluation for avian influenza, should be managed using isolation precautions identical to those recommended for patients with known Severe Acute Respiratory Syndrome (SARS). These include:

For additional information regarding these and other health-care isolation precautions, see the Guidelines for Isolation Precautions in Hospitals. These precautions should be continued for 14 days after onset of symptoms or until either an alternative diagnosis is established or diagnostic test results indicate that the patient is not infected with influenza A virus. Patients managed as outpatients or hospitalized patients discharged before 14 days with suspected avian influenza should be isolated in the home setting on the basis of principles outlined for the home isolation of SARS patients (see

Vaccination of Health-Care Workers against Human Influenza

Health-care workers involved in the care of patients with documented or suspected avian influenza should be vaccinated with the most recent seasonal human influenza vaccine. In addition to providing protection against the predominant circulating influenza strain, this measure is intended to reduce the likelihood of a health-care worker’s being co-infected with human and avian strains, where genetic rearrangement could take place, leading to the emergence of potential pandemic strain.

Surveillance and Monitoring of Health-Care Workers

See Also…

asteriskRespirators should be used in the context of a complete respiratory protection program as required by the Occupational Safety and Health Administration (OSHA). This includes training, fit-testing, and fit-checking to ensure appropriate respirator selection and use. To be effective, respirators must provide a proper sealing surface on the wearer's face. Detailed information on a respiratory protection program is provided at this OSHA web page.

Page last modified May 21, 2004

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