Epidemiology & Risk Factors

Collecting water from a stagnant pool.

Collecting water from a stagnant pool. Photo credit: Emily Staub, 2004, The Carter Center.

Today, GWD affects poor communities in remote parts of Africa that do not have safe water to drink. People become infected with Guinea worm by drinking stagnant water containing copepods (tiny “water fleas” too small to be clearly seen without a magnifying glass) that carry Guinea worm larvae (immature forms of the worm). The larvae are swallowed by the copepods that live in these stagnant water sources. The larvae need about 2 weeks to mature inside the copepods before they can infect humans. Unsafe stagnant water includes ponds, pools in drying riverbeds, and shallow hand-dug wells without surrounding protective walls. Anyone who drinks from contaminated water sources can become infected. GWD is not normally caught from drinking flowing water (rivers and streams) [1, 2, 3] . Alternatively, persons who live in countries where GWD is occurring (such as Chad, Ethiopia, Mali, and South Sudan) and consume raw or undercooked aquatic animals (such as small whole fish that have not been gutted, other fish, and frogs) might also be at risk for GWD [4] .

GWD transmission has a seasonal pattern. In dry regions, people generally get infected during the rainy season, when stagnant surface water is available. In wet regions, people generally get infected during the dry season, when surface water is drying up and becoming stagnant[2, 3] .

The risk for disease varies by sex, age, profession, and ethnicity. These differences reflect how and where people get their drinking water in different areas and countries. In general, about the same number of men and women get infected. GWD occurs in all age groups but it is most common among young adults 15–45 years old. This may be because of the type of work done by people this age. Farmers, herders, and those fetching drinking water for the household may be more likely to become infected, possibly because they drink contaminated stagnant water while away from home. In certain areas, GWD affects some ethnic groups more than others [1, 2, 3].

The greatest risk for GWD is having GWD the year before. People do not become immune to infection. Many people in affected villages suffer from GWD year after year. This is probably because the same water sources are repeatedly contaminated and conditions that support the spread of disease have not changed. It might also be related to some biological characteristic of the person that increases susceptibility. Not everyone drinking from the same contaminated water supply will become infected. A few people seem to keep getting infected while others drinking the same water do not [1, 3, 5] .

Since 2012, an unusual epidemiologic pattern has been recognized in Chad. While the number of cases in humans has remained limited, there have been large numbers of cases recognized in dogs, particularly in the area along the Chari River. This has led to consideration of the possibility of GWD transmission though a previously unrecognized route—consumption of fish, frogs, or other aquatic animals that carry Guinea worm larvae, but do not themselves suffer the effects of transmission [6]. The situation is being carefully investigated [7] and control measures (tethering of dogs, education to remind area residents to fully cook food and not feed fish guts to dogs) have been implemented[4].

While most Guinea worm infections in animals have occurred in dogs and most dog infections have occurred in Chad, dog infections have occurred in other countries as well and Guinea worms have infected other types of animals too. In 2018, Chad reported 1,040 Guinea worm-infected dogs and 25 cats; Ethiopia reported 11 infected dogs, five cats, and one baboon; and Mali reported 18 infected dogs and two cats.

References
      1. Cairncross, S., R. Muller, and N. Zagaria, Dracunculiasis (Guinea worm disease) and the eradication initiative. Clin Microbiol Rev, 2002. 15(2): p. 223–46.
      2. Greenaway, C., Dracunculiasis (Guinea worm disease). CMAJ, 2004. 170(4): p. 495–500.
      3. Ruiz-Tiben, E. and D.R. Hopkins, Dracunculiasis (Guinea worm disease) eradication. Adv Parasitol, 2006. 61: p. 275–309.
      4. Hopkins DR, et al., Progress Toward Global Eradication of Dracunculiasis, January 2016–June 2017. MMWR, 2017 Dec 8. 66(48): p. 1327–31.
      5. Tayeh, A., S. Cairncross, and G.H. Maude, Water sources and other determinants of dracunculiasis in the northern region of Ghana. J Helminthol, 1993. 67(3): p. 213–-25.
      6. Eberhard ML, Ruiz-Tiben E, Hopkins DR, Farrell C, Toe F, Weiss A, Withers PC Jr, Jenks MH, Thiele EA, Cotton JA, Hance Z, Holroyd N, Cama VA, Tahir MA, Mounda T. The Peculiar Epidemiology of Dracunculiasis in Chad. Am J Trop Med Hyg, 2014 Jan. 90(1): p. 60–71.
      7. World Health Organization. Dracunculiasis Eradication: Global Surveillance Summary, 2017. Wkly Epidemiol Rec. 93(21): p. 305–20.
      8. WHO Collaborating Center for Research Training and Eradication of Dracunculiasis, Guinea Worm Wrap Up #252, 2015, Centers for Disease Control and Prevention (CGH): Atlanta.
      9. WHO Collaborating Center for Research Training and Eradication of Dracunculiasis, Guinea Worm Wrap Up #256, 2015, Centers for Disease Control and Prevention (CGH): Atlanta.

     

Page last reviewed: May 2, 2019