Poliovirus Containment Partners
Implementation of Poliovirus Containment in the United States
The U.S. Department of Health and Human Services designated the U.S. National Authority for Containment (NAC) in January 2018. It is located at the Centers for Disease Control and Prevention.
NAC was designated to implement the WHO Global Action Plan to Minimize Poliovirus Facility–Associated Risk after Type-Specific Eradication of Wild Polioviruses and Sequential Cessation of Oral Poliovirus Vaccine Use (GAPIII) in the U.S.
In July 2022, WHO replaced GAPIII with the WHO Global Action Plan for Poliovirus Containment (GAP IV). WHO expects to complete the transition to GAPIV by July 2025.
Beginning in December 2018, the NAC launched an online survey to reach all U.S. facilities that may retain poliovirus materials. This includes those working with biological and wastewater materials. The survey builds on national surveys conducted in 2002 and 2015. The current survey represents an ongoing evaluation of the poliovirus inventory in the U.S.
All facilities that continue to handle and store wild and vaccine-derived poliovirus types 2 and 3 and oral polio vaccine type 2 infectious materials must be certified as a poliovirus-essential facility (PEF) to retain these materials. PEFs serve critical national and international functions. Those functions include vaccine production, vaccine testing, public health and virologic research, and diagnostics.
The NAC strongly encourages any U.S. facility to destroy unneeded or nonessential materials containing poliovirus. All facilities retaining poliovirus will require certification as a PEF when WHO declares poliovirus eradicated.
GAPIV specifies all poliovirus containment requirements including
- facility risk management,
- engineering controls,
- community population immunity, and
- local sanitation standards.
GAPIV focuses on risk elimination as a primary goal, wherever possible. GAPIV has shifted to a risk- and evidence-based approach for risk control. This approach does not change the tolerance for minimal risk.
GAPIII Containment Certification Scheme
The Containment Certification Scheme (CCS) was endorsed by the WHO Strategic Advisory Group of Experts on Immunization in October 2017. It outlines the steps that facilities must take to become a PEF. The NAC manages the U.S. facility application process and audits candidate PEFs to validate containment conditions and compliance with GAPIV.
National Authority for Containment (NAC):
Performs audits and provides certification to all PEFs according to CCS; ensures national poliovirus inventory is maintained
Global Commission for the Certification of the Eradication of Poliomyelitis (GCC):
Defines the parameters and processes by which polio eradication will be certified, Confirms the global containment of polioviruses has been met, Receives annual reports from the RCCs.
Containment Working Group (CWG):
Reviews and approves PEF applications and audits received from NACs for national containment certification and makes recommendations to the GCC
Containment Advisory Group (CAG):
Advisory body to the Director-General of WHO; makes recommendations on technical issues related to the implementation of containment requirements
Regional Commission for the Certification of the Eradication of Poliomyelitis (RCC):
Independent global experts who review national survey reports
National Certification Committee for Polio Eradication (NCC):
Independent experts who review, verify, and submit country documentation to RCC
Poliovirus Essential Facility (PEF):
A facility designated by the NAC as serving critical national/international functions involving handling and storage of poliovirus infectious or potentially infectious materials under GAP standards.