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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorothioic acid, O,O-dimethyl O-(2,4,5-trichlorophenyl) ester

RTECS #

TG0525000

CAS #

299-84-3

Updated

December 2015

Molecular Weight

321.54

Molecular Formula

C8H8Cl3O3PS

Synonyms

Blitex
Dermafosu (Polish)
Dermaphos
Dimethyl trichlorophenyl thiophosphate
Dow ET 14
Dow ET 57
Ectoral
ENT 23,284
ET 14
Etrolene
Fenchloorfos (Dutch)
Fenchlorfos
Fenchlorfosu (Polish)
Fenchlorphos
Korlan
Korlane
Moorman's Medicated Rid-Ezy
Nanchor
Nankor
O-(2,4,5-Trichloor-fenyl)-O,O-dimethyl-monothiofosfaat (Dutch)
O-(2,4,5-Trichlor-phenyl)-O,O-dimethyl-monothiophosphat (German)
O-(2,4,5-Tricloro-fenil)-O,O-dimetil-monotiofosfato (Italian)
O,O-Dimethyl O-(2,4,5-trichlorophenyl)thiophosphate
O,O-Dimethyl O-2,4,5-trichlorophenyl phosphorothioate
O,O-Dimethyl-O-(2,4,5-trichlorphenyl)-thionophosphat (German)
OMS 123
Phenchlorfos
Phenol, 2,4,5-trichloro-, O-ester with O,O-dimethyl phosphorothioate
Remelt
Ronnel
Ronnel (ACGIH:OSHA)
Rovan
Thiophosphate de O,O-dimethyle et de O-(2,4,5-trichlorophenyle) (French)
Trichlorometafos
Trolen
Trolene
Viozene

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sister chromatid exchangelymphocyte/human2 mg/LMUREAV 102,89,1982

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 368 mg/kg (16-22D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicNUPOBT 17,577,1979
oral/rat 6 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemJTEHD6 10,111,1982
oral/rabbit 650 mg/kg (6-18D pregnant)Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) systemAVSCA7 24,295,1983
oral/rabbit 162 mg/kg (6-18D pregnant)Reproductive: Other developmental abnormalitiesAVSCA7 24,295,1983
oral/mammal (species unspecified) 2100 mg/kg (30-50D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
AVSCA7 24,99,1983
oral/mammal (species unspecified) 2100 mg/kg (30-50D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Sex ratio
AVSCA7 24,99,1983

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 118 mg/kgPSEBAA 129,699,1968
intraperitoneal/rat lethal dose (50 percent kill): 2823 mg/kgPSEBAA 129,699,1968
oral/chicken lethal dose (50 percent kill): 6375 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BCTKAG 10,339,1977
oral/Dog lethal dose (50 percent kill): 500 mg/kg85GYAV -,26,1971
oral/domestic animal lowest published lethal dose: 1 gm/kgVETNAL 51(8),101,1974
oral/duck lethal dose (50 percent kill): 3500 mg/kgPCOC** -,965,1966
oral/guinea pig lethal dose (50 percent kill): 1400 mg/kgPCOC** -,965,1966
oral/mouse lethal dose (50 percent kill): 2 gm/kgPCOC** -,965,1966
oral/rabbit lethal dose (50 percent kill): 420 mg/kgPCOC** -,965,1966
oral/rat lethal dose (50 percent kill): 625 mg/kgGISAAA 45(6),14,1980
oral/turkey lethal dose (50 percent kill): 500 mg/kgJAFCAU 7,689,1959
oral/wild bird lethal dose (50 percent kill): 80 mg/kgTXAPA9 21,315,1972
skin/guinea pig lethal dose (50 percent kill): 2 gm/kg85DPAN -,-,1971/1976
skin/rabbit lethal dose (50 percent kill): 1 gm/kgFMCHA2 -,C265,1991
skin/rat lethal dose (50 percent kill): 2 gm/kgWRPCA2 9,119,1970
subcutaneous/chicken lethal dose (50 percent kill): >1600 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)BCPCA6 12,1377,1963
subcutaneous/rat lethal dose (50 percent kill): 1380 mg/kgGISAAA 52(11),24,1987
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 400 mg/kg30ZDA9 -,333,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 5940 mg/kg/2Y- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 23,1,1972
oral/rat lowest published toxic dose: 350 mg/kg/14D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
BCTKAG 10,351,1977

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg/m3 (inhal, vapor)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWAQMOAC #73-19,1973
TOXICOLOGY REVIEWRREVAH 46,1,1973
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWTOLED5 230,434,2014

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,206,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 mg/m3DTLVS* 3,222,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 mg/m3;KZW 10 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 mg/m3, MAY2011
Occupational Exposure Limit-FRANCEVME 10 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 10 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.3 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 10 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 10 mg/m3, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 10 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 15 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 15 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 10 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO RONNEL-air10H time-weighted average 10 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 67525; Number of Industries 2; Total Number of Facilities 333; Number of Occupations 2; Total Number of Employees Exposed 3824; Total Number of Female Employees Exposed 574
National Occupational Hazard Survey 1974Hazard Code 67525; Number of Industries 2; Total Number of Facilities 86; Number of Occupations 2; Total Number of Employees Exposed 383

Status in Federal Agencies

OrganizationReference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
On EPA IRIS database
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