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Registry of Toxic Effects of Chemical Substances (RTECS)

Pentaerythritol

RTECS #

RZ2490000

CAS #

115-77-5

Updated

September 2013

Molecular Weight

136.17

Molecular Formula

C5H12O4

Synonyms

1,3-Propanediol, 2,2-bis(hydroxymethyl)-
2,2-Bis(hydroxymethyl)-1,3-propanediol
Auxinutril
Hercules P6
Maxinutril
Methane tetramethylol
Monopentek
PE
Pentaerythrite
Pentaerythritol (ACGIH:OSHA)
Pentek
Tetrahydroxymethylmetane
Tetrakis(hydroxymethyl)methane
Tetramethylolmethane

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lethal concentration: >11 gm/m3/6HTXAPA9 6,351,1964
oral/guinea pig lethal dose (50 percent kill): 11300 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Behavioral: Ataxia
TXAPA9 6,351,1964
oral/mouse lethal dose (50 percent kill): 18500 mg/kgVCVGK* -,158,1984
oral/mouse lethal dose (50 percent kill): 25500 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Behavioral: Ataxia
TXAPA9 6,351,1964
oral/rabbit lethal dose (50 percent kill): 18500 mg/kgBehavioral: General anesthetic

Gastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes
GISAAA 36(2),25,1971
oral/rabbit lethal dose (50 percent kill): 18500 mg/kgVCVGK* -,158,1984
oral/rat lethal dose (50 percent kill): 19500 mg/kgBehavioral: General anesthetic

Gastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes
GISAAA 36(2),25,1971
oral/rat lethal dose (50 percent kill): 18500 mg/kgVCVGK* -,158,1984

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rabbit lowest published toxic dose: 10605 mg/kg/30W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Histamines (including liberation not immunochemical in origin)
GISAAA 36(2),25,1971
oral/rat lowest published toxic dose: 10600 µg/kg/30W- intermittentBehavioral: Alteration of classical conditioningGISAAA 36(2),25,1971

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 mg/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDNUISANCE PARTICULATESDTLVS* 3,199,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 10 mg/m3, FEB2006
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 10 mg/m3 (inhal), 4 mg/m3 (resp), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 4 mg/m3, JUN2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3 (respirable dust), 2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3 (total dust), 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3 (inhal. dust), OCT2007
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 4 mg/m3 (resp. dust), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTAERYTHRITOL, resp. fraction-air10H time-weighted average 5 mg/m3NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTAERYTHRITOL, total dust-air10H time-weighted average 10 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X6984; Number of Industries 1; Total Number of Facilities 18; Number of Occupations 2; Total Number of Employees Exposed 201
National Occupational Exposure Survey 1983Hazard Code 54185; Number of Industries 122; Total Number of Facilities 15717; Number of Occupations 97; Total Number of Employees Exposed 271094; Total Number of Female Employees Exposed 60232
National Occupational Hazard Survey 1974Hazard Code 54185; Number of Industries 93; Total Number of Facilities 6400; Number of Occupations 81; Total Number of Employees Exposed 89325

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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