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Registry of Toxic Effects of Chemical Substances (RTECS)

Oxirane, ((2-propenyloxy)methyl)-

RTECS #

RR0875000

CAS #

106-92-3

Updated

April 2017

Molecular Weight

114.16

Molecular Formula

C6H10O2

Synonyms

1-(Allyloxy)-2,3-epoxypropane
1,2-Epoxy-3-allyloxypropane
1-Allilossi-2,3 epossipropano (Italian)
1-Allyloxy-2,3-epoxy-propaan (Dutch)
1-Allyloxy-2,3-epoxypropan (German)
AGE (OSHA)
Allil-glicidil-etere (Italian)
Allyl 2,3-epoxypropyl ether
Allyl glycidol ether
Allyl glycidyl ether
Allyl glycidyl ether (ACGIH:OSHA)
Allylglycidaether (German)
Ether, allyl 2,3-epoxypropyl
Glycidyl allyl ether
NCI-C56666
Oxyde d'allyle et de glycidyle (French)
Propane, 1-(allyloxy)-2,3-epoxy-

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 97 mg severeAMIHAB 14,250,1956
eye /rabbit 750 µg/24H severe85JCAE -,772,1986
skin /rabbit 485 mg/3D moderateAMIHAB 14,250,1956
skin /rabbit 2 mg/24H severe85JCAE -,772,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster64800 µg/LNTPTR* NTP-TR-376,1990
DNA Damage/Escherichia coli1 µmol/LARTODN 46,277,1980
morphological transformfibroblast/mouse0.00001 pph/21D (-enzymatic activation step)EMMUEG 37,231,2001
mutation in microorganisms/Klebsiella pneumoniae500 µmol/L (-enzymatic activation step)MUREAV 89,269,1981
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+enzymatic activation step)NTPTR* NTP-TR-376,1990
mutation in microorganisms/Escherichia coli20 µmol/L (-enzymatic activation step)ARTODN 46,277,1980
other mutation test systems/Escherichia coli3300 µmol/LMUREAV 231,205,1990
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster5500 ppmENMUDM 7,349,1985
sister chromatid exchangeovary/hamster3300 µg/LNTPTR* NTP-TR-376,1990
sister chromatid exchangelung/hamster625 µmol/LMUREAV 249,55,1991

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 10 ppm/6H/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors
NTPTR* NTP-TR-376,1990
inhalation/mouse lowest published toxic concentration: 618 mg/kg/103W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
NTIS** PB90-260027
inhalation/rat lowest published toxic concentration: 10 ppm/6H/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
NTPTR* NTP-TR-376,1990
inhalation/rat lowest published toxic concentration: 309 mg/kg/103W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
NTIS** PB90-260027

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 270 ppm/4HEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
AMIHAB 14,250,1956
inhalation/rat lethal concentration (50 percent kill): 670 ppm/8HEye: Corneal damage

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Changes in structure or function of salivary glands
AMIHAB 14,250,1956
oral/mouse lethal dose (50 percent kill): 390 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
AMIHAB 14,250,1956
oral/rat lethal dose (50 percent kill): 1600 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia
AMIHAB 14,250,1956
skin/rabbit lethal dose (50 percent kill): 2550 mg/kgAMIHAB 14,250,1956

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 50 ppm/6H/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-376,1990
inhalation/mouse lowest published toxic concentration: 309 mg/kg/103W- intermittentLiver: Tumors

Tumorigenic: Active as anti-cancer agent
NTIS** PB90-260027
inhalation/mouse lowest published toxic concentration: 309 mg/kg/103W- intermittentBrain and Coverings: Tumors

Tumorigenic: Active as anti-cancer agent
NTIS** PB90-260027
inhalation/rat lowest published toxic concentration: 400 ppm/7H/10W- intermittentLung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AMIHAB 14,250,1956
inhalation/rat lowest published toxic concentration: 200 ppm/6H/14D- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes
NTPTR* NTP-TR-376,1990
intramuscular/rat lowest published toxic dose: 400 mg/kg/8D- intermittentBlood: Changes in bone marrow not included in above

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AEHLAU 2,50,1961

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 678,76,2009
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWTOLED5 204,148,2011
TOXICOLOGY REVIEWFCTOD7 55,596,2013
TOXICOLOGY REVIEWMUREAV 802,1,2016

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 5 ppm (22 mg/m3)DTLWS* 3,9,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 ppm (23 mg/m3), short term exposure limit 10 ppm (47 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (23 mg/m3), short term exposure limit 10 ppm (48 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 5 ppm (22 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1 ppm, short term exposure limit 5 ppm, NOV2011
Occupational Exposure Limit-FRANCEVME 5 ppm (22 mg/m3), Skin, C3 Carcinogen, FEB2006
Occupational Exposure Limit-ICELANDshort term exposure limit 5 ppm (22 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 5 ppm (22 mg/m3), short term exposure limit 10 ppm (44 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 ppm (22 mg/m3);short term exposure limit 10 ppm (44 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 ppm (23 mg/m3); short term exposure limit 10 ppm (47 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 1 ppm (4,7 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 3 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (22 mg/m3), carc 2, skin, sen, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 10 ppm (45 mg/m3), JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.5 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 10 ppm (45 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 10 ppm (45 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 10 ppm (45 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 10 ppm (45 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 10 ppm (45 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 10 ppm (45 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ALLYL GLYCIDYL ETHER-air10H time-weighted average 5 ppm;short term exposure limit 10 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 04530; Number of Industries 6; Total Number of Facilities 23; Number of Occupations 11; Total Number of Employees Exposed 2457; Total Number of Female Employees Exposed 29
National Occupational Hazard Survey 1974Hazard Code 04530; Number of Industries 9; Total Number of Facilities 153; Number of Occupations 24; Total Number of Employees Exposed 2769

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);equivocal evidence:mouse,rat
NIOSH Analytical Method, 1994: Allyl glycidyl ether, 2545
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978
NTP Carcinogenesis Studies (inhalation);some evidence:mouse NTPTR* NTP-TR-376,1990
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