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Registry of Toxic Effects of Chemical Substances (RTECS)

Nitrogen trifluoride

RTECS #

QX1925000

CAS #

7783-54-2

Updated

September 2013

Molecular Weight

71.01

Molecular Formula

F3N

Synonyms

Nitrogen fluoride (NF3)
Nitrogen trifluoride (ACGIH:OSHA)
Perfluoroammonia
Trifluoroammonia

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lethal concentration (50 percent kill): 9600 ppm/1HLung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia
AMRL** TR-69-84,1969
inhalation/mammal (species unspecified) lowest published toxic concentration: 200 mg/m3Blood: Other changes

Blood: Changes in erythrocyte (RBC) count
TOVEFN (2),37,2001
inhalation/monkey lethal concentration (50 percent kill): 7500 ppm/1HLung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia
AMRL** TR-69-84,1969
inhalation/mouse lethal concentration (50 percent kill): 2000 ppm/4H34ZIAG -,427,1969
inhalation/rat lethal concentration (50 percent kill): 6700 ppm/1HLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory stimulation
TXAPA9 26,1,1973
inhalation/rat lethal concentration (50 percent kill): 7900 mg/m3Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (2),37,2001
inhalation/rat lethal concentration (16 percent kill): 4250 mg/m3Vascular: Other changes

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
TOVEFN (2),37,2001
inhalation/rat lethal concentration (16 percent kill): 4250 mg/m3Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney

Kidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Other changes in urine composition
TOVEFN (2),37,2001
inhalation/rat lethal concentration (16 percent kill): 4250 mg/m3Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in spleen

Biochemical: Metabolism (intermediary): Other
TOVEFN (2),37,2001
intraperitoneal/rat lethal dose (50 percent kill): 26 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaTXAPA9 17,585,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 98.7 mg/m3/122D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Liver: Other changes
TOVEFN (2),37,2001
inhalation/rat lowest published toxic concentration: 98.7 mg/m3/122D- intermittentKidney, Ureter, and Bladder: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Other changes
TOVEFN (2),37,2001
inhalation/rat lowest published toxic concentration: 98.7 mg/m3/122D- intermittentBlood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
TOVEFN (2),37,2001
inhalation/rat lowest published toxic concentration: 10.2 mg/m3/182D- intermittentCardiac: Other changes

Liver: Other changes

Blood: Other changes
TOVEFN (2),37,2001
inhalation/rat lowest published toxic concentration: 10.2 mg/m3/182D- intermittentBlood: Changes in erythrocyte (RBC) countTOVEFN (2),37,2001
inhalation/rat lowest published toxic concentration: 1.18 mg/m3/182D- intermittentBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
TOVEFN (2),37,2001
inhalation/rat lowest published toxic concentration: 1.18 mg/m3/182D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TOVEFN (2),37,2001
inhalation/rat lowest published toxic dose: 100 ppm/7H/19W- intermittentLiver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Interstitial nephritis

Blood: Changes in spleen
TXAPA9 4,770,1962
inhalation/rat lowest published toxic concentration: 100 ppm/6H/2W- intermittentBlood: Normocytic anemiaNTIS** OTS0559285
intraperitoneal/rabbit lowest published toxic dose: 85 gm/kg/29D- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
TXAPA9 4,770,1962

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 ppm (29 mg/m3)DTLVS* 3,187,1971
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 ppm (29 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2.5 mg(F)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 10 ppm (29 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMtime-weighted average 2.5 mg(F)/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 ppm (29 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 2.5 mg(F)/m3, JUN2000
Occupational Exposure Limit-FINLANDshort term exposure limit 10 ppm (29 mg/m3), NOV2011
Occupational Exposure Limit-FINLANDtime-weighted average 2.5 mg(F)/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 10 ppm (30 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 1 mg(F)/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 10 ppm (29 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (30 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 ppm (30 mg/m3);short term exposure limit 15 ppm (45 mg/m3), 2004
Occupational Exposure Limit-MEXICOtime-weighted average 2.5 mg(F)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 ppm (29 mg/m3), JAN2002
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2.5 mg(F)/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 10 ppm (29 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAtime-weighted average 30 mg/m3, short term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 1 mg(F)/m3, KZG-week 4 mg(F)/m3, inhal, skin, JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 10 ppm (30 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 29 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 2.5 mg(F)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 10 ppm (29 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 10 ppm (29 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 10 ppm (29 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 10 ppm (29 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITROGEN TRIFLUORIDE-air10H time-weighted average 10 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 50885; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 1096; Total Number of Female Employees Exposed 140
National Occupational Hazard Survey 1974Hazard Code 50885; Number of Industries 1; Total Number of Facilities 11; Number of Occupations 3; Total Number of Employees Exposed 357

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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