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Registry of Toxic Effects of Chemical Substances (RTECS)

Iron carbonyl

RTECS #

NO4900000

CAS #

13463-40-6; 37220-42-1

Updated

September 2013

Molecular Weight

195.90

Molecular Formula

C5FeO5

Synonyms

FER pentacarbonyle (French)
Iron carbonyl (Fe(CO)5), (TB-5-11) (9CI)
Iron pentacarbonyl
Iron pentacarbonyl (ACGIH)
Iron, pentacarbonyl-
Pentacarbonyliron

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 140 ppm/30MEPASR* 8EHQ-0591-1177
inhalation/mouse lethal concentration (50 percent kill): 2190 mg/m3/30MAMIHAB 19,11,1959
inhalation/rabbit Lowest published lethal concentration: 250 ppm/45M34ZIAG -,335,1969
inhalation/rat lethal concentration (50 percent kill): 10 ppm/4HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0535889
intraperitoneal/mouse lethal dose (50 percent kill): 60 mg/kgEPASR* 8EHQ-0591-1177
intravenous/rabbit lethal dose (50 percent kill): 11 mg/kgJIHTAB 25,415,1943
oral/cat lethal dose (50 percent kill): 100 mg/kgEPASR* 8EHQ-0591-1177
oral/guinea pig lethal dose (50 percent kill): 22 mg/kgJIHTAB 25,415,1943
oral/mouse lethal dose (50 percent kill): 62 mg/kgGTPZAB 26(6),52,1982
oral/rabbit lethal dose (50 percent kill): 12 mg/kgJIHTAB 25,415,1943
oral/rat lowest published toxic dose: 40 gm/kgLiver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Changes in: Fe
RTOPDW 36,280,2002
oral/rat lethal dose (50 percent kill): 25 mg/kgEPASR* 8EHQ-0591-1177
skin/rabbit lethal dose (50 percent kill): 56 mg/kgLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0535885
subcutaneous/rabbit lethal dose (50 percent kill): 240 mg/kgJIHTAB 25,415,1943

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 15 ppm/6H/2D- intermittentLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Cyanosis

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BJIMAG 27,1,1970
oral/rat lowest published toxic dose: 157.5 gm/kg/6W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Fe
TOLED5 133,193,2002

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 ppm(Fe);short term exposure limit 0.2 ppm(Fe)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWAEHLAU 23,373,1971

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.01 ppm (0.08 mg/m3)DTLVS* 3,137,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg(Fe)/m3, JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 ppm (0.23 mg(Fe)/m3), short term exposure limit 0.2 ppm (0.45 mg(Fe)/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 ppm (0.8 mg/m3);KZW 0.4 ppm (3.2 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 ppm (0.23 mg(Fe)/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 0.2 ppm (0.46 mg(Fe)/m3), MAR2002
Occupational Exposure Limit-BELGIUMtime-weighted average 1 mg(Fe)/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.8 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 0.01 ppm (0.081 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 ppm (0.8 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 0.1 ppm (0.81 mg/m3), skin, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.8 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.1 ppm (0.8 mg/m3), short term exposure limit 0.2 ppm (1.6 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 ppm (0.2 mg(Fe)/m3);short term exposure limit 0.2 ppm, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 ppm (0.23 mg(Fe)/m3); short term exposure limit 0.2 ppm (0.45 mg(Fe)/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,1 ppm (0,8 mg/m3); short term exposure limit 0,2 ppm (1,6 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 ppm (0.8 mg/m3), KZG-week 0.2 ppm (1.6 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.08 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.01 ppm (0.08 mg(Fe)/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO IRON PENTACARBONYL (as Fe)-airtime-weighted average 0.1 ppm;short term exposure limit 0.2 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X6270; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 1822; Total Number of Female Employees Exposed 272

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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