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Registry of Toxic Effects of Chemical Substances (RTECS)

Fluorine

RTECS #

LM6475000

CAS #

7782-41-4

Updated

September 2013

Molecular Weight

38.00

Molecular Formula

F2

Synonyms

Bifluoriden (Dutch)
Fluor (Dutch, French, German, Polish)
Fluorine (ACGIH:OSHA)
Fluoro (Italian)
Fluorures acide (French)
Fluoruri acidi (Italian)
RCRA waste number P056
Saeure fluoride (German)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /Dog 68 ppm/1HAIHAAP 29,10,1968
eye /human 25 ppm/5M mildAIHAAP 29,10,1968
eye /mouse 467 ppm/5MAIHAAP 29,10,1968
eye /rat 140 ppm/30MAIHAAP 29,10,1968

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lethal concentration (50 percent kill): 250 mg/m3/60MVCVN5* -,342,1993
inhalation/Dog Lowest published lethal concentration: 28 mg/m3Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Bronchiectasis

Lung, Thorax, or Respiration: Cough
VCVN5* -,342,1993
inhalation/Dog lethal concentration (50 percent kill): 1120 mg/m3/15MBrain and Coverings: Recordings from specific areas of CNS

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Acute pulmonary edema
STGNBT -,234,1999
inhalation/Dog lethal concentration (50 percent kill): 1250 mg/m3/5MVCVN5* -,342,1993
inhalation/guinea pig lethal concentration (50 percent kill): 1250 mg/m3/5MVCVN5* -,342,1993
inhalation/guinea pig lethal concentration (50 percent kill): 170 ppm/1HEye: Iritis

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AIHAAP 29,10,1968
inhalation/guinea pig Lowest published lethal concentration: 160 mg/m3/3HLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN5* -,342,1993
inhalation/guinea pig lethal concentration (50 percent kill): 250 mg/m3/60MVCVN5* -,342,1993
inhalation/human lowest published toxic concentration: 77 mg/m3Lung, Thorax, or Respiration: CoughVCVN5* -,342,1993
inhalation/mouse lethal concentration (50 percent kill): 150 ppm/60MLung, Thorax, or Respiration: Other changes

Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Other changes
ENTOX* -,343,2005
inhalation/mouse Lowest published lethal concentration: 160 mg/m3/3HLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN5* -,342,1993
inhalation/mouse lethal concentration (50 percent kill): 150 ppm/1HEye: Iritis

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AIHAAP 29,10,1968
inhalation/mouse lethal concentration (50 percent kill): 1250 mg/m3/5MVCVN5* -,342,1993
inhalation/mouse lethal concentration (50 percent kill): 250 mg/m3/60MVCVN5* -,342,1993
inhalation/rabbit lethal concentration (50 percent kill): 1250 mg/m3/5MVCVN5* -,342,1993
inhalation/rabbit Lowest published lethal concentration: 160 mg/m3/3HLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN5* -,342,1993
inhalation/rabbit lethal concentration (50 percent kill): 270 ppm/30MEye: Iritis

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AIHAAP 29,10,1968
inhalation/rabbit lethal concentration (50 percent kill): 820 ppm/5MENTOX* -,343,2005
inhalation/rabbit lethal concentration (50 percent kill): 250 mg/m3/60MVCVN5* -,342,1993
inhalation/rat Lowest published lethal concentration: 160 mg/m3/3HLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN5* -,342,1993
inhalation/rat lethal concentration (50 percent kill): 1250 mg/m3/5MVCVN5* -,342,1993
inhalation/rat lethal concentration (50 percent kill): 185 ppm/1HEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AIHAAP 29,10,1968
inhalation/rat lethal concentration (50 percent kill): 250 mg/m3/60MVCVN5* -,342,1993
oral/rat lethal dose (75 percent kill): 50 mg/kgVCVN5* -,342,1993

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 3 mg/m3/30D- continuousEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Bronchiectasis

Lung, Thorax, or Respiration: Cough
VCVN5* -,342,1989
inhalation/guinea pig lowest published toxic concentration: 3 mg/m3/30D- continuousEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Bronchiectasis

Lung, Thorax, or Respiration: Cough
VCVN5* -,342,1989
inhalation/mouse lowest published toxic concentration: 3 mg/m3/30D- continuousEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Bronchiectasis

Lung, Thorax, or Respiration: Cough
VCVN5* -,342,1989
inhalation/rabbit lowest published toxic concentration: 3 mg/m3/30D- continuousEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Bronchiectasis

Lung, Thorax, or Respiration: Cough
VCVN5* -,342,1989
inhalation/rat lowest published toxic concentration: 1 mg/m3/24H/30D- continuousMusculoskeletal: Changes in teeth and supporting structures

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
VCVN5* -,343,1989
inhalation/rat lowest published toxic concentration: 10 mg/m3/2H/10D- intermittentLiver: Liver function tests impaired

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
STGNBT -,234,1999
inhalation/rat lowest published toxic concentration: 3 mg/m3/24H/35D- continuousEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Cough
VCVN5* -,342,1989
inhalation/rat lowest published toxic concentration: 25 mg/m3/24H/35D- continuousMusculoskeletal: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVN5* -,342,1989
inhalation/rat lowest published toxic concentration: 3 mg/m3/24H/35D- continuousMusculoskeletal: Changes in teeth and supporting structuresVCVN5* -,342,1989
inhalation/rat lowest published toxic concentration: 3 mg/m3/30D- continuousEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Bronchiectasis

Lung, Thorax, or Respiration: Cough
VCVN5* -,342,1989
oral/rat lowest published toxic dose: 75 mg/kg/30D- continuousMusculoskeletal: Changes in teeth and supporting structures

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
VCVN5* -,343,1989
oral/rat lowest published toxic dose: 630 mg/kg/6W- continuousMusculoskeletal: Changes in teeth and supporting structuresVCVN5* -,343,1989
oral/rat lowest published toxic dose: 1368.7 mg/kg/2Y- continuousLiver: Liver function tests impaired

Kidney, Ureter, and Bladder: Renal function tests depressed

Musculoskeletal: Other changes
VCVN5* -,343,1989

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 ppm;short term exposure limit 2 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWJAVMA4 164,277,1974
TOXICOLOGY REVIEWFOREAE 7,313,1942
TOXICOLOGY REVIEWKOTTAM 11,1300,1975
TOXICOLOGY REVIEWCLCHAU 19,361,1973
TOXICOLOGY REVIEWAJMEAZ 38,409,1965
TOXICOLOGY REVIEWIECHAD 26,791,1934
TOXICOLOGY REVIEWTOLED5 134,3,2002
TOXICOLOGY REVIEWENTOX* -,343,2005
TOXICOLOGY REVIEWHUTOX* -,661,1996
TOXICOLOGY REVIEWDERCL* 25,215,2007

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 ppm (2 mg/m3)DTLVS* 3,117,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.1 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 ppm (1.6 mg/m3), short term exposure limit 2 ppm (3.1 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 ppm (0.2 mg/m3);KZW 0.2 ppm (0.4 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 ppm (1.58 mg/m3), short term exposure limit 2 ppm (3.16 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.2 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 1.58 mg/m3 (1 ppm);short term exposure limit 3.16 mg/m3 (2 ppm), JUN2000
Occupational Exposure Limit-FINLANDshort term exposure limit 0.1 ppm (0.16 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVLE 1 ppm (1.58 mg/m3), VLE 2 ppm (3.16 mg/m3), FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 1.58 mg/m3, short term exposure limit 3.16 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.2 mg/m3), short term exposure limit 2 ppm (3.16 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.1 ppm (0.2 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 2.5 mg(F)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 ppm (1.6 mg/m3); short term exposure limit 2 ppm (3.1 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 ppm (0.2 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1 ppm (1,6 mg/m3); short term exposure limit 2 ppm (3,1 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.05 mg/m3, MAC(short term exposure limit) 0.4 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.03 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 ppm (0.2 mg/m3);short term exposure limit 0.3 ppm (0.5 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 ppm (0.15 mg/m3), KZG-week 0.2 ppm (0.3 mg/m3), JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.1 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.1 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.1 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 ppm (1.6 mg/m3);short term exposure limit 1 ppm (1.6 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 ppm (0.2 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.1 ppm (0.2 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.1 ppm (0.2 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 ppm (0.2 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUORINE-air10H time-weighted average 0.1 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 33370; Number of Industries 19; Total Number of Facilities 490; Number of Occupations 25; Total Number of Employees Exposed 12854; Total Number of Female Employees Exposed 2059
National Occupational Hazard Survey 1974Hazard Code 33370; Number of Industries 10; Total Number of Facilities 396; Number of Occupations 13; Total Number of Employees Exposed 2580

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182566/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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