Fluorine

RTECS #

LM6475000

CAS #

7782-41-4
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

38.00

Molecular Formula

F₂

Synonyms

Bifluoriden (Dutch)
Fluor (Dutch, French, German, Polish)
Fluorine (ACGIH:OSHA)
Fluoro (Italian)
Fluorures acide (French)
Fluoruri acidi (Italian)
RCRA waste number P056
Saeure fluoride (German)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /Dog	68 ppm/1H		AIHAAP 29,10,1968
eye /human	25 ppm/5M	mild	AIHAAP 29,10,1968
eye /mouse	467 ppm/5M		AIHAAP 29,10,1968
eye /rat	140 ppm/30M		AIHAAP 29,10,1968

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	lethal concentration (50 percent kill): 1120 mg/m³/15M	Brain and Coverings: Recordings from specific areas of CNS Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Lung, Thorax, or Respiration: Acute pulmonary edema	STGNBT -,234,1999
inhalation/Dog	lethal concentration (50 percent kill): 1250 mg/m³/5M		VCVN5* -,342,1993
inhalation/Dog	lethal concentration (50 percent kill): 250 mg/m³/60M		VCVN5* -,342,1993
inhalation/Dog	Lowest published lethal concentration: 28 mg/m³	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Bronchiectasis Lung, Thorax, or Respiration: Cough	VCVN5* -,342,1993
inhalation/guinea pig	Lowest published lethal concentration: 160 mg/m³/3H	Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVN5* -,342,1993
inhalation/guinea pig	lethal concentration (50 percent kill): 1250 mg/m³/5M		VCVN5* -,342,1993
inhalation/guinea pig	lethal concentration (50 percent kill): 250 mg/m³/60M		VCVN5* -,342,1993
inhalation/guinea pig	lethal concentration (50 percent kill): 170 ppm/1H	Eye: Iritis Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AIHAAP 29,10,1968
inhalation/human	lowest published toxic concentration: 77 mg/m³	Lung, Thorax, or Respiration: Cough	VCVN5* -,342,1993
inhalation/mouse	lethal concentration (50 percent kill): 150 ppm/60M	Lung, Thorax, or Respiration: Other changes Liver: Hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, and Bladder: Other changes	ENTOX* -,343,2005
inhalation/mouse	Lowest published lethal concentration: 160 mg/m³/3H	Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVN5* -,342,1993
inhalation/mouse	lethal concentration (50 percent kill): 1250 mg/m³/5M		VCVN5* -,342,1993
inhalation/mouse	lethal concentration (50 percent kill): 150 ppm/1H	Eye: Iritis Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AIHAAP 29,10,1968
inhalation/mouse	lethal concentration (50 percent kill): 250 mg/m³/60M		VCVN5* -,342,1993
inhalation/rabbit	lethal concentration (50 percent kill): 250 mg/m³/60M		VCVN5* -,342,1993
inhalation/rabbit	lethal concentration (50 percent kill): 270 ppm/30M	Eye: Iritis Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AIHAAP 29,10,1968
inhalation/rabbit	lethal concentration (50 percent kill): 1250 mg/m³/5M		VCVN5* -,342,1993
inhalation/rabbit	Lowest published lethal concentration: 160 mg/m³/3H	Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVN5* -,342,1993
inhalation/rabbit	lethal concentration (50 percent kill): 820 ppm/5M		ENTOX* -,343,2005
inhalation/rat	Lowest published lethal concentration: 160 mg/m³/3H	Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVN5* -,342,1993
inhalation/rat	lethal concentration (50 percent kill): 1250 mg/m³/5M		VCVN5* -,342,1993
inhalation/rat	lethal concentration (50 percent kill): 185 ppm/1H	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AIHAAP 29,10,1968
inhalation/rat	lethal concentration (50 percent kill): 250 mg/m³/60M		VCVN5* -,342,1993
oral/rat	lethal dose (75 percent kill): 50 mg/kg		VCVN5* -,342,1993

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	lowest published toxic concentration: 3 mg/m³/30D- continuous	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Bronchiectasis Lung, Thorax, or Respiration: Cough	VCVN5* -,342,1989
inhalation/guinea pig	lowest published toxic concentration: 3 mg/m³/30D- continuous	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Bronchiectasis Lung, Thorax, or Respiration: Cough	VCVN5* -,342,1989
inhalation/mouse	lowest published toxic concentration: 3 mg/m³/30D- continuous	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Bronchiectasis Lung, Thorax, or Respiration: Cough	VCVN5* -,342,1989
inhalation/rabbit	lowest published toxic concentration: 3 mg/m³/30D- continuous	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Bronchiectasis Lung, Thorax, or Respiration: Cough	VCVN5* -,342,1989
inhalation/rat	lowest published toxic concentration: 1 mg/m³/24H/30D- continuous	Musculoskeletal: Changes in teeth and supporting structures Lung, Thorax, or Respiration: Other changes Liver: Other changes	VCVN5* -,343,1989
inhalation/rat	lowest published toxic concentration: 10 mg/m³/2H/10D- intermittent	Liver: Liver function tests impaired Musculoskeletal: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	STGNBT -,234,1999
inhalation/rat	lowest published toxic concentration: 3 mg/m³/24H/35D- continuous	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Cough	VCVN5* -,342,1989
inhalation/rat	lowest published toxic concentration: 25 mg/m³/24H/35D- continuous	Musculoskeletal: Other changes Reproductive: Paternal effects: Testes, epididymis, sperm duct	VCVN5* -,342,1989
inhalation/rat	lowest published toxic concentration: 3 mg/m³/24H/35D- continuous	Musculoskeletal: Changes in teeth and supporting structures	VCVN5* -,342,1989
inhalation/rat	lowest published toxic concentration: 3 mg/m³/30D- continuous	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Bronchiectasis Lung, Thorax, or Respiration: Cough	VCVN5* -,342,1989
oral/rat	lowest published toxic dose: 75 mg/kg/30D- continuous	Musculoskeletal: Changes in teeth and supporting structures Lung, Thorax, or Respiration: Other changes Liver: Other changes	VCVN5* -,343,1989
oral/rat	lowest published toxic dose: 630 mg/kg/6W- continuous	Musculoskeletal: Changes in teeth and supporting structures	VCVN5* -,343,1989
oral/rat	lowest published toxic dose: 1368.7 mg/kg/2Y- continuous	Liver: Liver function tests impaired Kidney, Ureter, and Bladder: Renal function tests depressed Musculoskeletal: Other changes	VCVN5* -,343,1989

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 1 ppm;short term exposure limit 2 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		JAVMA4 164,277,1974
TOXICOLOGY REVIEW		FOREAE 7,313,1942
TOXICOLOGY REVIEW		KOTTAM 11,1300,1975
TOXICOLOGY REVIEW		CLCHAU 19,361,1973
TOXICOLOGY REVIEW		AJMEAZ 38,409,1965
TOXICOLOGY REVIEW		IECHAD 26,791,1934
TOXICOLOGY REVIEW		TOLED5 134,3,2002
TOXICOLOGY REVIEW		ENTOX* -,343,2005
TOXICOLOGY REVIEW		HUTOX* -,661,1996
TOXICOLOGY REVIEW		DERCL* 25,215,2007
TOXICOLOGY REVIEW		RTOPDW 54,247,2009

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 1 ppm (2 mg/m³)	DTLVS* 3,117,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypt	time-weighted average 0.1 ppm (0.2 mg/m³), JAN1993
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 ppm (1.6 mg/m³), short term exposure limit 2 ppm (3.1 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.1 ppm (0.2 mg/m³);KZW 0.2 ppm (0.4 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1 ppm (1.58 mg/m³), short term exposure limit 2 ppm (3.16 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.1 ppm (0.2 mg/m³), MAY2011
Occupational Exposure Limit-EC	time-weighted average 1.58 mg/m³ (1 ppm);short term exposure limit 3.16 mg/m³ (2 ppm), JUN2000
Occupational Exposure Limit-FINLAND	short term exposure limit 0.1 ppm (0.16 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VLE 1 ppm (1.58 mg/m³), VLE 2 ppm (3.16 mg/m³), FEB2006
Occupational Exposure Limit-HUNGARY	time-weighted average 1.58 mg/m³, short term exposure limit 3.16 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.1 ppm (0.2 mg/m³), short term exposure limit 2 ppm (3.16 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.1 ppm (0.2 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 2.5 mg(F)/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 1 ppm (1.6 mg/m³); short term exposure limit 2 ppm (3.1 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.1 ppm (0.2 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 1 ppm (1,6 mg/m³); short term exposure limit 2 ppm (3,1 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 0.05 mg/m³, MAC(short term exposure limit) 0.4 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.03 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 0.1 ppm (0.2 mg/m³);short term exposure limit 0.3 ppm (0.5 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.1 ppm (0.15 mg/m³), KZG-week 0.2 ppm (0.3 mg/m³), JAN2011
Occupational Exposure Limit-THAILAND	time-weighted average 0.1 ppm (0.2 mg/m³), JAN1993
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.1 ppm (0.2 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 0.1 ppm (0.2 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 1 ppm (1.6 mg/m³);short term exposure limit 1 ppm (1.6 mg/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.1 ppm (0.2 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.1 ppm (0.2 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.1 ppm (0.2 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.1 ppm (0.2 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUORINE-air	10H time-weighted average 0.1 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 33370; Number of Industries 19; Total Number of Facilities 490; Number of Occupations 25; Total Number of Employees Exposed 12854; Total Number of Female Employees Exposed 2059
National Occupational Hazard Survey 1974	Hazard Code 33370; Number of Industries 10; Total Number of Facilities 396; Number of Occupations 13; Total Number of Employees Exposed 2580

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182566/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health