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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethane, 1,1,1-trichloro-2,2-bis(p-methoxyphenyl)-

RTECS #

KJ3675000

CAS #

72-43-5

Updated

April 2017

Molecular Weight

345.66

Molecular Formula

C16H15Cl3O2

Synonyms

1,1'-(2,2,2-Trichloroethylidene)bis(4-methoxybenzene)
1,1,1-Trichlor-2,2-bis(4-methoxy-phenyl)-aethan (German)
1,1,1-Trichloro-2,2-bis(4-methoxyphenyl)ethane
1,1,1-Trichloro-2,2-bis(p-anisyl)ethane
1,1,1-Trichloro-2,2-bis(p-methoxyphenyl)ethane
1,1,1-Trichloro-2,2-di(4-methoxyphenyl)ethane
1,1-Bis(p-methoxyphenyl)-2,2,2-trichloroethane
2,2,2-Trichloro-1,1-bis(4-methoxyphenyl)ethane
2,2-Bis(4-methoxyphenyl)-1,1,1-trichloroethane
2,2-Bis(p-anisyl)-1,1,1-trichloroethane
2,2-Bis(p-methoxyphenyl)-1,1,1-trichloroethane
2,2-Di-(p-methoxyphenyl)-1,1,1-trichloroethane
2,2-Di-p-anisyl-1,1,1-trichloroethane
4,4-(2,2,2-Trichloroethylidene)dianisole
Benzene, 1,1'-(2,2,2-trichloroethylidene)bis(4-methoxy-
Di(p-methoxyphenyl)-trichloromethyl methane
Dianisyltrichlorethane
Dimethoxy-DDT
DMDT
ENT 1,716
Ethane, 2,2-bis(p-anisyl)-1,1,1-trichloro-
Higalmetox
Marlate
Methoxcide
Methoxychlor
Methoxychlor (ACGIH:OSHA)
Methoxychlor 2 EC
Methoxychlor technical
Methoxy-DDT
Metoksychlor (Polish)
Metox
Mezox K
Moxie
NCI-C00497
OMS 466
p,p'-Dimethoxydiphenyltrichloroethane
p,p'-Dwumetoksydwufenylotrojchloroetan (Polish)
p,p'-Methoxychlor
RCRA waste number U247

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/mouse6 mg/kg/50D- intermittentFOMOAJ 35,361,1976
Cytogenetic Analysisintraperitoneal/hamster50 mg/kgARTODN 58,152,1986
DNA Damageliver/rat150 µmol/LEMMUEG 24,181,1994
micronucleus testsubcutaneous/mouse49.5 mg/kg/3D- intermittentREPTED 17,79,2003
morphological transformembryo/hamster10 mg/LMUREAV 356,85,1996
morphological transformfibroblast/mouse2 mg/LJJIND8 67,1303,1981
mutation in microorganismslymphocyte/mouse10 mg/L (+enzymatic activation step)EMMUEG 12(Suppl 13),103,1988
sperm morphologyoral/rat28 gm/kg/10W-continuousPSEBAA 176,187,1984

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 800 mg/kg (1D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
REPTED 11,703,1997
intraperitoneal/mouse 320 mg/kg (20D prior to copulation)Reproductive: Maternal effects: Ovaries, fallopian tubesTXAPA9 240,1,2009
oral/rat 280 mg/kg (7D male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male
TOXID9 78,188,2004
oral/rat 1400 mg/kg (7D male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Other effects on male
TOXID9 78,188,2004
oral/rat 216 mg/kg (15-22D preg/10D after birth)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
ARTODN 78,232,2004
oral/rat 46.5 mg/kg (7D preg-77D after birth)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects

Reproductive: Effects on newborn: Delayed effects
TOXID9 60,29,2001
oral/rat 1720 mg/kg (multigeneration)Reproductive: Specific developmental abnormalities: Urogenital systemTOXID9 66,299,2002
oral/mouse 0.14 mg/kg (11-17D pregnant)Reproductive: Other effects on female

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical
NETEEC 24,55,2002
oral/rat 2458 mg/kg (7-22D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TOLED5 135,199,2002
oral/rat 3072 mg/kg (7-22D preg/4-7D after birth)Reproductive: Specific developmental abnormalities: Endocrine systemTOLED5 135,199,2002
oral/rat 1760 mg/kg (1-22D preg/22D after birth)Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
TOSCF2 66,91,2002
oral/rat 1760 mg/kg (1-22D preg/22D after birth)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Delayed effects
ETOPFR 18,161,2004
oral/rat 330 mg/kg (7-21D preg/51D after birth)Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system
TXCYAC 207,271,2005
oral/mouse 2000 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemHBPTO* 1,733,2001
oral/rat 210 mg/kg (14-20D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)ENVRAL 18,437,1979
oral/mouse 140 µg/kg (11-17D pregnant)Reproductive: Maternal effects: Postpartum

Reproductive: Other effects on female

Reproductive: Effects on newborn: Behavioral
NETEEC 24,55,2002
oral/rat 1720 mg/kg (1-22D preg/21D after birth)Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial systemTXCYAC 172,205,2002
oral/rat 216 mg/kg (15-21D preg/10D after birth)Reproductive: Specific developmental abnormalities: Endocrine systemTOXID9 72,77,2003
oral/rat 1080 mg/kg (15-21D preg/10D after birth)Reproductive: Specific developmental abnormalities: Urogenital systemTOXID9 72,77,2003
oral/rat 1 gm/kg (11-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 90,82,2006
oral/rat 1720 mg/kg (1-22D preg/21D after birth)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic
TOXID9 90,238,2006
oral/rat 50 mg/kg (multigeneration)Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTPTR* NTR-MG96004
oral/rat 0.5 mg/kg (multigeneration)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)
NTPTR* NTR-MG96004
oral/rat 0.055 mg/kg (multigeneration)Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)NTPTR* NTR-MG96004
oral/rat 5 mg/kg (multigeneration)Reproductive: Specific developmental abnormalities: Endocrine systemNTPTR* NTR-MG96004
oral/mammal (species unspecified) 100 mg/kg (1D preg-28D after birth)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Physical
NETEEC 28,103,2006
oral/rat 39 mg/kg (7D preg-64D after birth)Reproductive: Effects on newborn: Biochemical and metabolicTXCYAC 211,207,2005
oral/rat 216 mg/kg (15D preg-10D after birth)Reproductive: Effects on newborn: Biochemical and metabolicTXAPA9 208,127,2005
oral/rat 40 mg/kg (multigeneration)Reproductive: Effects on newborn: PhysicalTOSCF2 91,93,2006
oral/rat 1.3 gm/kg (3W male/ 3W pre-3W after birth)Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial systemJTPAE7 17,165,2004
oral/rat 638 mg/kg (3W male/ 3W pre-3W after birth)Reproductive: Specific developmental abnormalities: Urogenital systemJTPAE7 18,89,2005
oral/rat 1.9 gm/kg (3W male/ 3W pre-3W after birth)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Specific developmental abnormalities: Homeostasis

Reproductive: Other developmental abnormalities
JTPAE7 18,89,2005
oral/rat 6.4 gm/kg (3W male/ 3W pre-3W after birth)Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system
JTPAE7 18,89,2005
oral/rat 6.4 gm/kg (3W male/ 3W pre-3W after birth)Reproductive: Specific developmental abnormalities: Homeostasis

Reproductive: Other developmental abnormalities
JTPAE7 18,89,2005
oral/rat 100 mg/kg (1D prior to copulation)Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Other effects on female
TOXID9 -,234,2008
oral/mouse 640 mg/kg (20D prior to copulation)Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Ovaries, fallopian tubes
TOXID9 -,283,2008
oral/rat 340 µg/kg (5-21D pregnant)Reproductive: Effects on newborn: BehavioralNETEEC 31,203,2009
oral/rat 66 gm/kg (33D male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
JPETAB 138,126,1962
oral/rat 2 gm/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TXAPA9 45,435,1978
oral/rat 2 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTXAPA9 45,435,1978
oral/rat 4250 mg/kg (42D pre-21D after birth)Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
JAFCAU 22,969,1974
oral/rat 10625 mg/kg (42D pre-21D after birth)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
JAFCAU 22,969,1974
oral/mouse 1 gm/kg (20D pregnant)Reproductive: Maternal effects: Ovaries, fallopian tubesREPTED 5,139,1991
oral/mouse 900 mg/kg (6-8D pregnant)Reproductive: Maternal effects: Uterus, cervix, vaginaREPTED 6,431,1992
oral/mouse 2 gm/kg (6-15D pregnant)Reproductive: Maternal effects: ParturitionREPTED 6,431,1992
oral/mouse 3 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathREPTED 6,431,1992
oral/rabbit 330 mg/kg (6-27D pregnant)Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system
CGANE7 39,190,1999
oral/rat 9800 mg/kg (multigeneration)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
TOXID9 15,164,1995
oral/rat 50400 mg/kg (multigeneration)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
TOXID9 15,164,1995
oral/rat 12600 mg/kg (multigeneration)Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
TOXID9 15,164,1995
oral/rat 1600 mg/kg (1-8D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)TXAPA9 97,454,1989
oral/rat 600 mg/kg (1-3D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
TXAPA9 97,454,1989
oral/rat 1000 mg/kg (4-8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TXAPA9 97,454,1989
oral/rat 2150 mg/kg (0-22D preg/21D after birth)Reproductive: Specific developmental abnormalities: Urogenital systemHBPTO* 2,1340,2001
oral/rat 18 gm/kg (14D prior to copulation/0-22D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)HBPTO* 2,1340,2001
oral/rat 2000 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HBPTO* 2,1340,2001
oral/rat 400 mg/kg (1-2D pregnant)Reproductive: Other effects to embryo or fetusTXAPA9 102,110,1990
oral/rat 300 mg/kg (1-3D pregnant)Reproductive: Other effects to embryo or fetusTXAPA9 102,110,1990
oral/rat 10.8 gm/kg (43D male/43D pre-1D after birth)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)FAATDF 12,92,1989
oral/rat 11.2 gm/kg (43D male/43D pre-5D after birth)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)FAATDF 12,92,1989
oral/rat 12.6 gm/kg (6W prior to copulation)Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Physical
JAFCAU 22,969,1974
oral/rat 23.8 gm/kg (73D pre-25D after birth)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)FAATDF 12,92,1989
oral/rat 5.4 gm/kg (43D male/43D pre-1D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)FAATDF 12,92,1989
oral/rat 6.6 gm/kg (43D male/43D pre-25D after birth)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
FAATDF 12,92,1989
oral/rat 6.6 gm/kg (43D male/43D pre-25D after birth)Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
FAATDF 12,92,1989
oral/rat 4250 mg/kg (6W pre-21D after birth)Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
JAFCAU 22,969,1974
oral/rat 50 mg/kg (multigenerations)Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
JAFCAU 22,969,1974
oral/rat 7300 mg/kg (73D prior to copulation)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)FAATDF 12,92,1989
oral/rat 8000 mg/kg (6W prior to copulation/22D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)
JAFCAU 22,969,1974
oral/rat 8600 mg/kg (43D male/43D prior to copulation)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)FAATDF 12,92,1989
oral/rat 8750 mg/kg (5W prior to copulation)Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)JAFCAU 22,969,1974
oral/rat 9500 mg/kg (73D pre-1D after birth)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
FAATDF 12,92,1989
subcutaneous/mouse 99 mg/kg (5-7D pregnant)Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Behavioral
NETEEC 24,29,2002
subcutaneous/mouse 0.7 µg/kg (12-18D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
TXAPA9 183,10,2002
subcutaneous/mouse 99 mg/kg (5-7D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Behavioral
NETEEC 24,29,2002
subcutaneous/mouse 49.5 mg/kg (2-4D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)REPTED 17,79,2003
subcutaneous/mouse 99 mg/kg (2-4D pregnant)Reproductive: Effects on fertility: Other measures of fertilityREPTED 17,79,2003
subcutaneous/mouse 99 mg/kg (5-7D pregnant)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
REPTED 13,405,1999
subcutaneous/mouse 500.1 mg/kg (2-4D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Physical
REPTED 18,103,2004
subcutaneous/mouse 500.1 mg/kg (2-4D pregnant)Reproductive: Effects on newborn: Other neonatal measures or effects

Reproductive: Effects on newborn: Physical
REPTED 18,103,2004
subcutaneous/mouse 500.1 mg/kg (2-4D pregnant)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
REPTED 21,154,2006
subcutaneous/domestic animal 300 mg/kg (30-90D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Endocrine system
TXAPA9 247,98,2010
unreported route/mouse 64 mg/kg (1D prior to copulation)Reproductive: Maternal effects: Ovaries, fallopian tubesTOXID9 78,73,2004
unreported route/mouse 640 mg/kg (20D prior to copulation)Reproductive: Maternal effects: Ovaries, fallopian tubesTOXID9 78,73,2004
unreported route/rat 2100 mg/kg (7D preg-7D after birth)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)HBPTO* 1,734,2001
unreported route/rat 50 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Physical
HBPTO* 1,734,2001
unreported route/rat 5800 mg/kg (15-22D preg/21D after birth)Reproductive: Specific developmental abnormalities: Musculoskeletal systemHBPTO* 1,741,2001
unreported route/rat 1450 mg/kg (15-22D preg/21D after birth)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
HBPTO* 1,741,2001
unreported route/rat 725 mg/kg (15-22D preg/21D after birth)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Physical
HBPTO* 1,741,2001
unreported route/rat 1600 mg/kg (1-8D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)HBPTO* 1,733,2001
unreported route/mammal (species unspecified) 1000 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemHBPTO* 1,733,2001
unreported route/rat 7 gm/kg (70D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)AHEMA5 9,89,1980
unreported route/rat 2100 mg/kg (21D prior to copulation)Reproductive: Maternal effects: OogenesisAHEMA5 9,89,1980
unreported route/rat 9100 mg/kg (70D male/21D prior to copulation)Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)AHEMA5 9,89,1980

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 383 gm/kg/3Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
EVHPAZ 36,205,1980
oral/mouse lowest published toxic dose: 56700 mg/kg/90W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Reproductive: Tumorigenic effects: Testicular tumors
JCROD7 93,173,1979
oral/mouse toxic dose: 62622 mg/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
EVHPAZ 36,205,1980
oral/mouse lowest published toxic dose: 65.7 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Testicular tumors
HBPTO* 2,1339,2001
oral/rat lowest published toxic dose: 73 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteriaHBPTO* 2,1339,2001
oral/rat toxic dose: 80 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Reproductive: Tumorigenic effects: Ovarian tumors
LIFSAK 24,1367,1979
oral/rat toxic dose: 72800 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
EVHPAZ 36,205,1980
oral/rat toxic dose: 87360 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
EVHPAZ 36,205,1980
oral/rat toxic dose: 10920 mg/kg/1Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
AIPTAK 83,491,1950
oral/rat toxic dose: 45500 mg/kg/1Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
AIPTAK 83,491,1950
oral/rat lowest published toxic dose: 18200 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Prostate tumors
EVHPAZ 36,205,1980
oral/rat toxic dose: 41 gm/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Multiple effects

Lung, Thorax, or Respiration: Other changes
TXAPA9 11,88,1967

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, endocrine tumor Inhibitor Concentration Low: 5 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,107,2012
In Vitro/jvxInhibitor Concentration Low: 5 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,107,2012
In Vitro/mtdInhibitor Concentration Low: 10 mg/L/48HEndocrine: Other changes

In Vitro Toxicity Studies: Cell growth: Colony formation
TXAPA9 253,161,2011
In Vitro/mtdInhibitor Concentration Low: 1 mg/L/48HEndocrine: Other changesTXAPA9 253,161,2011
In Vitro/mtdInhibitor Concentration Low: 1 mg/L/24HIn Vitro Toxicity Studies: Other assaysTXAPA9 253,161,2011
In Vitro/Rat, neurons Inhibitor Concentration Low: 40 µmol/L/1HIn Vitro Toxicity Studies: Other assaysNRTXDN 44,204,2014
In Vitro/Rat, testis Inhibitor Concentration Low: 1 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,107,2012
intraperitoneal/hamster lethal dose (50 percent kill): 500 mg/kgARTODN 58,152,1986
intraperitoneal/rat lowest published toxic dose: 50 mg/kgEndocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight
TXAPA9 14,358,1969
oral/duck lethal dose (50 percent kill): >2 gm/kgPEMNDP 9,574,1991
oral/hamster lethal dose (50 percent kill): 2000 mg/kgHBPTO* 2,1337,2001
oral/human lowest published lethal dose: 6430 mg/kgPCOC** -,705,1966
oral/mouse lethal dose (50 percent kill): 5000 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Urine volume increased
VCVGK* -,297,1994
oral/mouse lethal dose (50 percent kill): 510 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Ataxia
GISAAA 58(1),44,1993
oral/mouse lethal dose (50 percent kill): 1850 mg/kgHBPTO* 2,1337,2001
oral/rabbit lethal dose (50 percent kill): >6 gm/kgSPEADM 78-1,16,1978
oral/rat lethal dose (50 percent kill): 5000 mg/kgHBPTO* 2,1337,2001
oral/rat lethal dose (50 percent kill): 5000 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Urine volume increased
VCVGK* -,297,1994
oral/rat lowest published toxic dose: 100 mg/kgEndocrine: Other changesTOXID9 -,234,2008
oral/rat lowest published toxic dose: 50 mg/kgReproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Metabolism (intermediary): Other proteins
ARTODN 82,833,2008
oral/rat lethal dose (50 percent kill): 1855 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Ataxia
GISAAA 58(1),44,1993
oral/rat lowest published toxic dose: 4000 mg/kgReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 6,491,1992
skin/human lowest published toxic dose: 2414 mg/kgBehavioral: Somnolence (general depressed activity)PCOC** -,705,1966
skin/rabbit lethal dose (50 percent kill): >6 gm/kgWRPCA2 3,28,1964
skin/rat lethal dose (50 percent kill): >6 gm/kgCMEP** -,1,1956
subcutaneous/rat lowest published toxic dose: 95 mg/kgEndocrine: EstrogenicJAFCAU 18,1108,1970
unreported route/mammal (species unspecified) lowest published toxic dose: 4000 mg/kgReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
HBPTO* 1,733,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 353 mg/kg/10D- intermittentRelated to Chronic Data: Changes in ovarian weightBIREBV 42,573,1990
intraperitoneal/mouse lowest published toxic dose: 1777 mg/kg/10D- intermittentEndocrine: Other changesBIREBV 42,573,1990
intraperitoneal/mouse lowest published toxic dose: 178 mg/kg/10D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina
BIREBV 42,573,1990
intraperitoneal/mouse lowest published toxic dose: 378 mg/kg/14D- intermittentEndocrine: Effect on menstrual cycle

Reproductive: Maternal effects: Ovaries, fallopian tubes

Related to Chronic Data: Changes in ovarian weight
REPTED 9,379,1995
intraperitoneal/mouse lowest published toxic dose: 640 mg/kg/20D- intermittentReproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Ovaries, fallopian tubes
TOSCF2 68,473,2002
intraperitoneal/mouse lowest published toxic dose: 80 mg/kg/2W- intermittentReproductive: Maternal effects: Ovaries, fallopian tubesTOXID9 60,383,2001
intraperitoneal/mouse lowest published toxic dose: 320 mg/kg/20D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
TXAPA9 216,436,2006
intraperitoneal/mouse lowest published toxic dose: 320 mg/kg/20D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other
NRTXDN 30,274,2009
intraperitoneal/mouse lowest published toxic dose: 1280 mg/kg/20D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
NRTXDN 30,274,2009
intraperitoneal/rat lowest published toxic dose: 600 mg/kg/3D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOLED5 144,93,2003
intraperitoneal/rat lowest published toxic dose: 1500 mg/kg/3D- intermittentLiver: Changes in liver weightTOLED5 144,93,2003
intraperitoneal/rat lowest published toxic dose: 600 mg/kg/3D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)TOLED5 144,93,2003
oral/Dog lowest published toxic dose: 365000 mg/kg/26W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,298,1994
oral/Dog lowest published toxic dose: 112000 mg/kg/8W- continuousEye: Other eye effects

Behavioral: Tetany

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,298,1994
oral/Dog lowest published toxic dose: 168 gm/kg/24W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1338,2001
oral/Dog lowest published toxic dose: 84 gm/kg/6W- continuousBehavioral: Convulsions or effect on seizure thresholdHBPTO* 2,1338,2001
oral/Dog lowest published toxic dose: 126 gm/kg/9W- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHBPTO* 2,1338,2001
oral/mammal (species unspecified) lowest published toxic dose: 7000 mg/kg/70D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
HBPTO* 1,733,2001
oral/monkey lowest published toxic dose: 4550 mg/kg/26W- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Alteration of operant conditioning
NETEEC 26,799,2004
oral/monkey lowest published toxic dose: 18250 mg/kg/1Y- intermittentBehavioral: Alteration of operant conditioning

Behavioral: Change in psychophysiological tests
NETEEC 24,87,2002
oral/monkey lowest published toxic dose: 18250 mg/kg/1Y- intermittentEye: Other eye effects

Behavioral: Change in psychophysiological tests
NETEEC 24,87,2002
oral/monkey lowest published toxic dose: 6100 mg/kg/122D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainTOXID9 60,300,2001
oral/mouse lowest published toxic dose: 975 mg/kg/39D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TOLED5 142,61,2003
oral/mouse lowest published toxic dose: 640 mg/kg/20D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TOXID9 44,441,2005
oral/mouse lowest published toxic dose: 150 mg/kg/5D- intermittentImmunological Including Allergic: Decreased immune response

Immunological Including Allergic: Increased immune response
TXCYAC 289,132,2011
oral/mouse lowest published toxic dose: 150 mg/kg/5D- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation

Immunological Including Allergic: Uncharacterized (multiple organ involvement)
TXCYAC 309,1,2013
oral/mouse lowest published toxic dose: 80 mg/kg/10D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubesTOXID9 72,26,2003
oral/mouse lowest published toxic dose: 4000 mg/kg/4W- intermittentReproductive: Maternal effects: Ovaries, fallopian tubesREPTED 6,93,1992
oral/mouse lowest published toxic dose: 2000 mg/kg/10D- intermittentReproductive: Maternal effects: ParturitionHBPTO* 1,733,2001
oral/rabbit lowest published toxic dose: 0.8 gm/kg/4D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Interstitial nephritis
JPETAB 99,140,1950
oral/rat lowest published toxic dose: 5400 mg/kg/18D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Behavioral: Tremor
JPETAB 99,140,1950
oral/rat lowest published toxic dose: 101.25 gm/kg/45D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHBPTO* 2,1337,2001
oral/rat lowest published toxic dose: 87.6 gm/kg/2Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1338,2001
oral/rat lowest published toxic dose: 76 gm/kg/760D- continuousReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male
HBPTO* 2,1340,2001
oral/rat lowest published toxic dose: 1400 mg/kg/14D- continuousReproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Other effects on female
HBPTO* 2,1340,2001
oral/rat lowest published toxic dose: 500 mg/kg/10D- intermittentReproductive: Other effects on female

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1340,2001
oral/rat lowest published toxic dose: 1400 mg/kg/14D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Other proteins
JPETAB 294,308,2000
oral/rat lowest published toxic dose: 14 gm/kg/28D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Menstrual cycle changes or disorders

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
ARTODN 75,513,2001
oral/rat lowest published toxic dose: 2.8 gm/kg/28D- intermittentReproductive: Maternal effects: Uterus, cervix, vagina

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ARTODN 75,513,2001
oral/rat lowest published toxic dose: 560 mg/kg/28D- intermittentBiochemical: Metabolism (intermediary): Plasma proteins not involving coagulationARTODN 75,513,2001
oral/rat lowest published toxic dose: 14 gm/kg/28D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Metabolism (intermediary): Lipids including transport
ARTODN 75,513,2001
oral/rat lowest published toxic dose: 2.8 gm/kg/28D- intermittentReproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
ARTODN 75,513,2001
oral/rat lowest published toxic dose: 560 mg/kg/28D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)ARTODN 75,513,2001
oral/rat lowest published toxic dose: 2.8 gm/kg/28D- intermittentLiver: Other changes

Endocrine: Adrenal cortex hyperplasia
ARTODN 75,513,2001
oral/rat lowest published toxic dose: 14 gm/kg/28D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
ARTODN 75,513,2001
oral/rat lowest published toxic dose: 700 mg/kg/14D- intermittentReproductive: Maternal effects: Uterus, cervix, vaginaTOSCF2 54,154,2000
oral/rat lowest published toxic dose: 1250 mg/kg/25D- intermittentReproductive: Maternal effects: Menstrual cycle changes or disordersTOSCF2 54,154,2000
oral/rat lowest published toxic dose: 266 mg/kg/19W- intermittentLiver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GISAAA 53(10),82,1988
oral/rat lowest published toxic dose: 602 mg/kg/43W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 58(1),44,1993
oral/rat lowest published toxic dose: 20000 mg/kg/5D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductREPTED 6,491,1992
oral/rat lowest published toxic dose: 20000 mg/kg/4D- intermittentRelated to Chronic Data: Changes in prostate weightREPTED 6,491,1992
oral/rat lowest published toxic dose: 800 mg/kg/8D- intermittentEndocrine: Other changesTXAPA9 97,454,1989
oral/rat lowest published toxic dose: 1600 mg/kg/8D- intermittentRelated to Chronic Data: Changes in uterine weightTXAPA9 97,454,1989
oral/rat lowest published toxic dose: 1500 mg/kg/3D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTXAPA9 97,454,1989
oral/rat lowest published toxic dose: 1000 mg/kg/5D- intermittentEndocrine: Other changesTXAPA9 97,454,1989
oral/rat lowest published toxic dose: 2500 mg/kg/5D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in uterine weight
TXAPA9 97,454,1989
oral/rat lowest published toxic dose: 600 gm/kg/10D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJPETAB 99,140,1950
oral/rat lowest published toxic dose: 30 gm/kg/10D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Behavioral: Food intake (animal)
JPETAB 99,140,1950
oral/rat lowest published toxic dose: 13500 mg/kg/45D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainJPETAB 99,140,1950
oral/rat lowest published toxic dose: 405 gm/kg/45D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Liver: Changes in liver weight
JPETAB 99,140,1950
oral/rat lowest published toxic dose: 405 gm/kg/45D- continuousRelated to Chronic Data: Changes in testicular weightJPETAB 99,140,1950
oral/rat lowest published toxic dose: 90 gm/kg/30D- continuousRelated to Chronic Data: Changes in testicular weight

Behavioral: Food intake (animal)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JPETAB 99,140,1950
oral/rat lowest published toxic dose: 21 gm/kg/7D- continuousReproductive: Paternal effects: Testes, epididymis, sperm ductTICEL* 13,369,1981
oral/rat lowest published toxic dose: 2000 mg/kg/10D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 72,132,2003
oral/rat lowest published toxic dose: 750 mg/kg/3D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXAPA9 193,66,2003
oral/rat lowest published toxic dose: 1400 mg/kg/7D- intermittentEndocrine: Estrogenic

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in testicular weight
TOXID9 44,112,2005
oral/rat lowest published toxic dose: 1075.2 mg/kg/7D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainTOLED5 135,199,2002
oral/rat lowest published toxic dose: 27960 mg/kg/60D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
VCVGK* -,298,1994
oral/rat lowest published toxic dose: 2100 mg/kg/6W- continuousRelated to Chronic Data: Changes in uterine weight

Liver: Changes in liver weight

Liver: Other changes
JAFCAU 22,969,1974
oral/rat lowest published toxic dose: 5250 mg/kg/6W- continuousRelated to Chronic Data: Changes in ovarian weightJAFCAU 22,969,1974
oral/rat lowest published toxic dose: 8750 mg/kg/5W- continuousEndocrine: Effect on menstrual cycleJAFCAU 22,969,1974
oral/rat lowest published toxic dose: 4200 mg/kg/12W- continuousRelated to Chronic Data: Changes in ovarian weight

Liver: Other changes
JAFCAU 22,969,1974
oral/rat lowest published toxic dose: 1600 mg/kg/8D- intermittentReproductive: Maternal effects: Uterus, cervix, vaginaTXAPA9 90,330,1987
oral/rat lowest published toxic dose: 1400 mg/kg/56D- intermittentEndocrine: Change in gonadotropinsTXAPA9 86,474,1986
oral/rat lowest published toxic dose: 2800 mg/kg/56D- intermittentEndocrine: Other changesTXAPA9 86,474,1986
oral/rat lowest published toxic dose: 1225 mg/kg/7W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFAATDF 12,92,1989
oral/rat lowest published toxic dose: 2100 mg/kg/6W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFAATDF 12,92,1989
oral/rat lowest published toxic dose: 3500 mg/kg/5W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFAATDF 12,92,1989
oral/rat lowest published toxic dose: 700 mg/kg/1W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFAATDF 12,92,1989
oral/rat lowest published toxic dose: 125 mg/kg/5D- intermittentEndocrine: Effect on menstrual cycle

Reproductive: Maternal effects: Uterus, cervix, vagina
FAATDF 12,92,1989
oral/rat lowest published toxic dose: 200 mg/kg/4D- intermittentEndocrine: Effect on menstrual cycle

Reproductive: Maternal effects: Uterus, cervix, vagina
FAATDF 12,92,1989
oral/rat lowest published toxic dose: 600 mg/kg/3D- intermittentEndocrine: Effect on menstrual cycle

Reproductive: Maternal effects: Uterus, cervix, vagina
FAATDF 12,92,1989
oral/rat lowest published toxic dose: 6900 mg/kg/69D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubesFAATDF 12,92,1989
oral/rat lowest published toxic dose: 11900 mg/kg/119D- intermittentEndocrine: Changes in pituitary weight

Endocrine: Changes in adrenal weight

Related to Chronic Data: Changes in ovarian weight
FAATDF 12,92,1989
oral/rat lowest published toxic dose: 23800 mg/kg/119D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
FAATDF 12,92,1989
oral/rat lowest published toxic dose: 2300 mg/kg/23D- intermittentReproductive: Other effects on maleFAATDF 12,92,1989
oral/rat lowest published toxic dose: 3100 mg/kg/62D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
FAATDF 12,92,1989
oral/rat lowest published toxic dose: 1550 mg/kg/62D- intermittentEndocrine: Change in gonadotropins

Endocrine: Other changes
FAATDF 12,92,1989
oral/rat lowest published toxic dose: 5600 mg/kg/56D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct
FAATDF 12,92,1989
oral/rat lowest published toxic dose: 11200 mg/kg/56D- intermittentEndocrine: Changes in pituitary weight

Related to Chronic Data: Changes in testicular weight
FAATDF 12,92,1989
oral/rat lowest published toxic dose: 7500 mg/kg/75D- intermittentEndocrine: Androgenic

Endocrine: Changes in pituitary weight

Related to Chronic Data: Changes in testicular weight
FAATDF 12,92,1989
oral/rat lowest published toxic dose: 15000 mg/kg/75D- intermittentBlood: Other changesFAATDF 12,92,1989
oral/rat lowest published toxic dose: 1720 mg/kg/42D- intermittentBehavioral: Food intake (animal)TXCYAC 172,205,2002
oral/rat lowest published toxic dose: 280 mg/kg/7D- intermittentEndocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 78,188,2004
oral/rat lowest published toxic dose: 1400 mg/kg/7D- intermittentEndocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other
TOXID9 78,188,2004
oral/rat lowest published toxic dose: 32.5 mg/kg/65D- continuousBlood: Changes in spleenTOXID9 60,29,2001
oral/rat lowest published toxic dose: 200 mg/kg/4D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
ARTODN 76,692,2002
oral/rat lowest published toxic dose: 350 mg/kg/7D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in prostate weight
ARTODN 76,692,2002
oral/rat lowest published toxic dose: 69 mg/kg/3D- intermittentRelated to Chronic Data: Changes in uterine weightTXAPA9 218,280,2007
oral/rat lowest published toxic dose: 250 mg/kg/20D- intermittentReproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Maternal effects: Menstrual cycle changes or disorders
NTPTR* RACB-20103
oral/rat lowest published toxic dose: 1000 mg/kg/20D- intermittentLiver: Changes in liver weight

Endocrine: Changes in pituitary weight

Related to Chronic Data: Changes in ovarian weight
NTPTR* RACB-20103
oral/rat lowest published toxic dose: 3600 mg/kg/72D- intermittentImmunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Decrease in cellular immune response
NTPTR* MG96004
oral/rat lowest published toxic dose: 280 mg/kg/7D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductREPTED 21,148,2006
oral/rat lowest published toxic dose: 1400 mg/kg/7D- intermittentEndocrine: Other changes

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
REPTED 21,148,2006
subcutaneous/mouse lowest published toxic dose: 500.1 mg/kg/3D- intermittentReproductive: Effects on fertility: Other measures of fertilityREPTED 18,103,2004
subcutaneous/mouse lowest published toxic dose: 150 mg/kg/3D- intermittentRelated to Chronic Data: Changes in uterine weight

Endocrine: Estrogenic
EVHPAZ 104,1296,1996
subcutaneous/rat lowest published toxic dose: 750 mg/kg/30D- intermittentBrain and Coverings: Recordings from specific areas of CNSTXAPA9 197,319,2004
subcutaneous/rat lowest published toxic dose: 750 mg/kg/30D- intermittentEndocrine: Change in LH

Endocrine: Androgenic

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS
FCTOD7 46,1570,2008
unreported route/mammal (species unspecified) lowest published toxic dose: 8000 mg/kg/4D- continuousReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
HBPTO* 1,733,2001
unreported route/mouse lowest published toxic dose: 640 mg/kg/20D- intermittentEndocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 78,73,2004
unreported route/mouse lowest published toxic dose: 1280 mg/kg/20D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubesTOXID9 90,80,2006
unreported route/mouse lowest published toxic dose: 80 mg/kg/10D- intermittentReproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Uterus, cervix, vagina
TOXID9 66,377,2002
unreported route/mouse lowest published toxic dose: 320 mg/kg/10D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)TOXID9 66,377,2002
unreported route/rat lowest published toxic dose: 60000 mg/kg/300D- continuousReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
HBPTO* 1,733,2001
unreported route/rat lowest published toxic dose: 1600 mg/kg/8D- continuousReproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
HBPTO* 1,733,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 20,259,1979
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 20,259,1979
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWRREVAH 56,107,1975
TOXICOLOGY REVIEWCTOXAO 13,231,1978
TOXICOLOGY REVIEWTOLED5 127,101,2002
TOXICOLOGY REVIEWREPTED 22,164,2006
TOXICOLOGY REVIEWMUREAV 616,7,2007
TOXICOLOGY REVIEWENTOX* -,258,2005
TOXICOLOGY REVIEWENTOX* -,61,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWREPTED 23,337,2007
TOXICOLOGY REVIEWREPTED 23,374,2007
TOXICOLOGY REVIEWREPTED 23,297,2007
TOXICOLOGY REVIEWREPTED 25,316,2007
TOXICOLOGY REVIEWMUREAV 543,251,2003
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWFCTOD7 46,813,2008
TOXICOLOGY REVIEWFESTAS 90,911,2008
TOXICOLOGY REVIEWREPTED 31,337,2011
TOXICOLOGY REVIEWNBREV* 23,1011,1999
TOXICOLOGY REVIEWMUREAV 727,62,2011
TOXICOLOGY REVIEWREPTED 31,363,2011
TOXICOLOGY REVIEWMUREAV 726,91,2011
TOXICOLOGY REVIEWREPTED 33,269,2012
TOXICOLOGY REVIEWREPTED 38,1,2013
TOXICOLOGY REVIEWMUREAV 764-765,36,2014
TOXICOLOGY REVIEWTOLED5 201,152,2011
TOXICOLOGY REVIEWTOLED5 202,36,2011
TOXICOLOGY REVIEWREPTED 49,117,2014
TOXICOLOGY REVIEWTXCYAC 307,35,2013
TOXICOLOGY REVIEWTXCYAC 307,42,2013
TOXICOLOGY REVIEWTXCYAC 307,74,2013
TOXICOLOGY REVIEWTXCYAC 307,89,2013
TOXICOLOGY REVIEWTXCYAC 307,123,2013
TOXICOLOGY REVIEWTOLED5 230,146,2014
TOXICOLOGY REVIEWTXAPA9 261,227,2012
TOXICOLOGY REVIEWFCTOD7 86,298,2015

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,132,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 mg/m3DTLVS* 3,152,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 15 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 10 mg/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 15 mg/m3, inhal, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 10 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 15 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 15 mg/m3, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 15 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHOXYCHLOR-airCarcinogen (0.07 mg/m3 LOQ)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 46210; Number of Industries 2; Total Number of Facilities 504; Number of Occupations 2; Total Number of Employees Exposed 3417
National Occupational Hazard Survey 1974Hazard Code 46210; Number of Industries 2; Total Number of Facilities 248; Number of Occupations 2; Total Number of Employees Exposed 638

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/100202/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-BALB/c-3T3
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-35,1978
On EPA IRIS database
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